STRINGSTRING
cbiP cbiP cbiA cbiA hisH hisH purF purF carB carB gltB gltB pabA pabA asnB asnB yfeJ yfeJ guaA guaA yneH yneH trpD trpD carA carA purG purG glnA glnA glmS glmS pyrG pyrG yafJ yafJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cbiPSynthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. (506 aa)
cbiASynthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Is able to use other nucleotide triphosphates as substrate, such as GTP or UTP, although less efficiently than ATP; Belongs to the CobB/CbiA family. (459 aa)
hisHGlutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (197 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
carBCarbamoyl-phosphate synthase large chain. (SW:CARB_SALTY). (1075 aa)
gltBSimilar to E. coli glutamate synthase, large subunit (AAC76244.1); Blastp hit to AAC76244.1 (1517 aa), 95% identity in aa 32 - 1517. (1486 aa)
pabAP-aminobenzoate synthetase component II; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB (By similarity). (187 aa)
asnBSimilar to E. coli asparagine synthetase B (AAC73768.1); Blastp hit to AAC73768.1 (554 aa), 94% identity in aa 1 - 554. (554 aa)
yfeJPutative GMP synthase; Contains glutamine amidotransferase domain; hypothetical 18.7 Kda protein in pdxK-cysM intergenic region. (SW:YFEJ_SALTY). (239 aa)
guaAGMP synthetase; Catalyzes the synthesis of GMP from XMP. (525 aa)
yneHSimilar to E. coli putative glutaminase (AAC74597.1); Blastp hit to AAC74597.1 (308 aa), 91% identity in aa 1 - 308; Belongs to the glutaminase family. (308 aa)
trpDAnthranilate synthase, component II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concen [...] (531 aa)
carACarbamoyl-phosphate synthetase, glutamine-hydrolysing small subunit; Carbamoyl-phosphate synthase small chain. (SW:CARA_SALTY); Belongs to the CarA family. (382 aa)
purGPhosphoribosylformylglycinamidine synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
glnAGlutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. (469 aa)
glmSL-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
yafJSimilar to E. coli putative amidotransferase (AAC73327.1); Blastp hit to AAC73327.1 (255 aa), 93% identity in aa 1 - 255. (255 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.