STRINGSTRING
ompX ompX STM0920 STM0920 ompF ompF STM1043 STM1043 ompA ompA STM1131 STM1131 flgH flgH fhuE fhuE ycfM ycfM pagC pagC mipA mipA lppB lppB lpp lpp ssaC ssaC ssaJ ssaJ slyB slyB ompN ompN STM1530 STM1530 nmpC nmpC yncD yncD STM1669 STM1669 ompW ompW ybfM ybfM lolB lolB emtA emtA ompS ompS wza wza stcC stcC yohG yohG cirA cirA ompC ompC fadL fadL pgtE pgtE yfeN yfeN nlpB nlpB sinH sinH yfgL yfgL yfhD yfhD yfiO yfiO smpA smpA iroN iroN prgK prgK invG invG invH invH nlpD nlpD stdB stdB STM3031 STM3031 STM3038 STM3038 mltC mltC rlpB rlpB rlpA rlpA pagP pagP fepA fepA fimD fimD tsx tsx foxA foxA STM0350 STM0350 STM0346 STM0346 stbC stbC phoE phoE pagN pagN safC safC rcsF rcsF yaeT yaeT stfC stfC fhuA fhuA stiC stiC imp imp yraM yraM yhbN yhbN hofQ hofQ lpfC lpfC yiaD yiaD sadA sadA pldA pldA yshA yshA yiiY yiiY btuB btuB lamB lamB blc blc ytfM ytfM stjB stjB sthB sthB ychP ychP pal pal ybhC ybhC bcfC bcfC STM0034 STM0034
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ompXOuter membrane protease, receptor for phage OX2; Similar to E. coli outer membrane protein X (AAC73901.1); Blastp hit to AAC73901.1 (171 aa), 91% identity in aa 1 - 171. (171 aa)
STM0920Fels-1 prophage attachment and invasion protein; Ail and ompX homolog (gi|2232362). (172 aa)
ompFOuter membrane protein 1a (ia;b;f), porin; Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2 (By similarity). (363 aa)
STM1043Attachment and invasion protein homolog (gi|2232362). (165 aa)
ompAPutative membrane component hydrogenase; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage. (350 aa)
STM1131Putative outer membrane protein; Similar to E. coli orf, hypothetical protein (AAC77267.1); Blastp hit to AAC77267.1 (241 aa), 26% identity in aa 4 - 239. (230 aa)
flgHFlagellar biosynthesis protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (232 aa)
fhuEOuter membrane receptor for Fe(III)-coprogen; Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid uptake; similar to E. coli outer membrane receptor for ferric iron uptake (AAC74186.1); Blastp hit to AAC74186.1 (729 aa), 81% identity in aa 5 - 729. (724 aa)
ycfMPutative outer membrane lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). (212 aa)
pagCReduced macrophage survival protein; Essential for full virulence and survival within macrophages; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. Ail family. (185 aa)
mipAScaffolding protein for murein-synthesizing holoenzyme; Similar to E. coli orf, hypothetical protein (AAC74852.1); Blastp hit to AAC74852.1 (248 aa), 83% identity in aa 1 - 248. (248 aa)
lppBPutative methyl-accepting chemotaxis protein; Plays an important role in virulence. A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non- covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (By similarity). (79 aa)
lppMurein lipoprotein; Plays an important role in virulence. A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non- covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (By similarity). (78 aa)
ssaCSecretion system apparatus protein; SpiA (gi|1498307). (497 aa)
ssaJSecretion system apparatus protein; Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB toxin. (249 aa)
slyBOuter membrane lipoprotein SLYB precursor. (SW:SLYB_SALTY). (155 aa)
ompNOuter membrane protein N; Non-specific porin; similar to E. coli putative outer membrane protein (AAC74459.1); Blastp hit to AAC74459.1 (377 aa), 81% identity in aa 1 - 377. (377 aa)
STM1530Similar to E. coli putative outer membrane protein (AAC74459.1); Blastp hit to AAC74459.1 (377 aa), 61% identity in aa 2 - 377; Belongs to the Gram-negative porin family. (372 aa)
nmpCNew outer membrane protein; Forms pores that allow passive diffusion of small molecules across the outer membrane; Belongs to the Gram-negative porin family. (362 aa)
yncDSimilar to E. coli putative outer membrane receptor for iron transport (AAC74533.1); Blastp hit to AAC74533.1 (700 aa), 84% identity in aa 1 - 700. (706 aa)
STM1669Invasin-like protein; Homology to invasin C of Yersinia; similar to E. coli putative factor (AAC74304.1); Blastp hit to AAC74304.1 (417 aa), 30% identity in aa 38 - 403. (660 aa)
ompWOuter membrane protein W; Colicin S4 receptor; putative transporter; similar to E. coli putative outer membrane protein (AAC74338.1); Blastp hit to AAC74338.1 (212 aa), 88% identity in aa 1 - 212. (212 aa)
ybfMPutative outer membrane protein; Involved in the uptake of chitosugars. (468 aa)
lolBOuter membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (207 aa)
emtAMembrane-bound lytic murein transglycosylase E; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. (203 aa)
ompSSimilar to E. coli putative outer membrane protein (AAC74459.1); Blastp hit to AAC74459.1 (377 aa), 71% identity in aa 1 - 236, 60% identity in aa 174 - 377; Belongs to the Gram-negative porin family. (398 aa)
wzaPutative polysaccharide export protein; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium. (379 aa)
stcCSimilar to E. coli putative outer membrane protein (AAC75170.1); Blastp hit to AAC75170.1 (826 aa), 74% identity in aa 1 - 826. (829 aa)
yohGPutative outer membrane efflux protein; Similar to E. coli putative channel/filament proteins (AAC75199.1); Blastp hit to AAC75199.1 (398 aa), 85% identity in aa 1 - 396. (478 aa)
cirAOuter membrane porin; Receptor for colicin I; requires TonB; similar to E. coli outer membrane receptor for iron-regulated colicin I receptor; porin; requires tonB gene product (AAC75216.1); Blastp hit to AAC75216.1 (663 aa), 88% identity in aa 1 - 663. (663 aa)
ompCOuter membrane protein 1b (ib;c); Forms pores that allow passive diffusion of small molecules across the outer membrane. (378 aa)
fadLTransport of long-chain fatty acids; Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity). Belongs to the OmpP1/FadL family. (437 aa)
pgtEOuter membrane protein E; Protease that can cleave T7 RNA polymerase. Specific for paired basic residues; Belongs to the peptidase A26 family. (312 aa)
yfeNPutative outer membrane protein; Similar to E. coli putative sugar hydrolase (AAC75461.1); Blastp hit to AAC75461.1 (254 aa), 85% identity in aa 1 - 254. (253 aa)
nlpBLipoprotein-34; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (344 aa)
sinHSinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531). (730 aa)
yfgLPutative serine/threonine protein kinase; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa)
yfhDPutative periplasmic amino acid binding protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (514 aa)
yfiOPutative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa)
smpASmall membrane protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (112 aa)
iroNTonB-dependent siderophore receptor protein; Similar to E. coli outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D (AAC73685.1); Blastp hit to AAC73685.1 (746 aa), 52% identity in aa 3 - 728, 44% identity in aa 245 - 746. (726 aa)
prgKCell invasion protein; Required for invasion of epithelial cells. Could be involved in protein secretion; Belongs to the YscJ lipoprotein family. (252 aa)
invGOuter membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. (562 aa)
invHInvasion protein; Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Pilot protein that is required for the proper localization of the secretin InvG/SctC in the outer membrane. Required for the secretion of the Sip virulence factors. (147 aa)
nlpDLipoprotein; Activator of the cell wall hydrolase AmiC. Required for septal murein cleavage and daughter cell separation during cell division (By similarity); Belongs to the E.coli NlpD/Haemophilus LppB family. (377 aa)
stdBSimilar to E. coli putative membrane protein (AAC76082.1); Blastp hit to AAC76082.1 (821 aa), 42% identity in aa 20 - 817. (829 aa)
STM3031Ail and ompX-like protein; Similar to E. coli outer membrane protein X (AAC73901.1); Blastp hit to AAC73901.1 (171 aa), 29% identity in aa 1 - 171. (178 aa)
STM3038Similar to E. coli putative lipoprotein (AAC75903.1); Blastp hit to AAC75903.1 (259 aa), 84% identity in aa 8 - 259. (252 aa)
mltCMembrane-bound lytic murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (361 aa)
rlpBA minor lipoprotein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane; Belongs to the LptE lipoprotein family. (196 aa)
rlpAA minor lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides; Belongs to the RlpA family. (381 aa)
pagPPhoPQ-activated gene; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. Required for resistance to cationic antimicrobial peptides (CAMPs). Modifications of lipid A with a palmitate chain allow to evade host immune defenses by resisting antimicrobial peptides and attenuating the inflammatory response to infection triggered by lipopolysaccharide through the Toll-like receptor 4 (TLR4) signal transduction pathway. (190 aa)
fepASimilar to E. coli outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D (AAC73685.1); Blastp hit to AAC73685.1 (746 aa), 81% identity in aa 1 - 746. (751 aa)
fimDOuter membrane usher protein; Involved in the export and assembly of FimA fimbrial subunits across the outer membrane; Belongs to the fimbrial export usher family. (870 aa)
tsxNucleoside channel; Functions as substrate-specific channel for nucleosides and deoxynucleosides. Functions also in albicidin uptake and as receptor for colicin K; Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family. (287 aa)
foxAFerrioxamine receptor; Ferrioxamine binding and uptake, in association with the TonB protein; Belongs to the TonB-dependent receptor family. (702 aa)
STM0350Homology to outer membrane efflux protein; Similar to E. coli putative resistance protein (AAC73673.1); Blastp hit to AAC73673.1 (457 aa), 37% identity in aa 7 - 457. (503 aa)
STM0346Putative outer membrane protein; Unknown (gi|6707276). (174 aa)
stbCPutative fimbriae; Similar to E. coli outer membrane protein; export and assembly of type 1 fimbriae, interrupted (AAC77273.1); Blastp hit to AAC77273.1 (878 aa), 30% identity in aa 30 - 870. (853 aa)
phoEOuter membrane pore protein e (e,ic,nmpab); Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes; Belongs to the Gram-negative porin family. (350 aa)
pagNHomolog of sapA; Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells. (239 aa)
safCPutative fimbriae usher; Similar to E. coli putative outer membrane protein, export function (AAC73634.1); Blastp hit to AAC73634.1 (867 aa), 34% identity in aa 35 - 862. (836 aa)
rcsFRegulator in colanic acid synthesis; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (134 aa)
yaeTPutative outer membrane antigen; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (804 aa)
stfCOuter membrane usher protein StfC (gi|3747030). (885 aa)
fhuAIron complex outermembrane recepter protein; Similar to E. coli outer membrane protein receptor for ferrichrome, colicin M, and phages T1, T5, and phi80 (AAC73261.1); Blastp hit to AAC73261.1 (747 aa), 68% identity in aa 1 - 747. (729 aa)
stiCPutative fimbrial usher; Similar to E. coli putative outer membrane protein (AAC76178.1); Blastp hit to AAC76178.1 (838 aa), 39% identity in aa 20 - 558, 34% identity in aa 493 - 837. (848 aa)
impOrganic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (786 aa)
yraMPutative transglycosylase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (680 aa)
yhbNPutative ABC superfamily transport protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (184 aa)
hofQPutative transport protein; Possibly in biosynthesis of type IV pilin; similar to E. coli putative transport portein (AAC76416.1); Blastp hit to AAC76416.1 (412 aa), 86% identity in aa 1 - 412. (412 aa)
lpfCLong polar fimbrial outer membrane usher protein; Involved in the export and assembly of LpfA fimbrial subunits across the outer membrane; Belongs to the fimbrial export usher family. (842 aa)
yiaDSimilar to E. coli putative outer membrane protein (AAC76576.1); Blastp hit to AAC76576.1 (219 aa), 94% identity in aa 1 - 219. (220 aa)
sadAPutative inner membrane protein; Involved in cell aggregation, biofilm formation, and adhesion to human intestinal epithelial cells; Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family. (1461 aa)
pldAOuter membrane phospholipase A; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities; Belongs to the phospholipase A1 family. (289 aa)
yshAPutative outer membrane protein; Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is unknown (By similarity); Belongs to the oligogalacturonate-specific porin KdgM (TC 1.B.35) family. OmpL subfamily. (230 aa)
yiiYPutative outer membrane protein; Hypothetical 15.6 Kda protein in RHAT 5'region. (SW:YIIY_SALTY). (227 aa)
btuBOuter membrane receptor for transport of vitamin B12, E colicins, and bacteriophage BF23; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. (614 aa)
lamBPhage lambda receptor protein; Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages; Belongs to the porin LamB (TC 1.B.3) family. (452 aa)
blcOuter membrane lipoprotein; Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids. (177 aa)
ytfMPutative outer membrane protein; Similar to E. coli orf, hypothetical protein (AAC77177.1); Blastp hit to AAC77177.1 (577 aa), 90% identity in aa 3 - 577. (577 aa)
stjBSimilar to E. coli putative outer membrane protein (AAC76248.1); Blastp hit to AAC76248.1 (793 aa), 40% identity in aa 29 - 793. (802 aa)
sthBSimilar to E. coli putative outer membrane protein, export function (AAC73634.1); Blastp hit to AAC73634.1 (867 aa), 38% identity in aa 35 - 862. (845 aa)
ychPSimilar to E. coli putative factor (AAC74304.1); Blastp hit to AAC74304.1 (417 aa), 77% identity in aa 1 - 417. (474 aa)
palTol protein required for outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (174 aa)
ybhCSimilar to E. coli putative pectinesterase (AAC73859.1); Blastp hit to AAC73859.1 (427 aa), 86% identity in aa 1 - 427. (427 aa)
bcfCFimbrial usher; Bovine colonization factor BcfC (gi|4530570). (873 aa)
STM0034Putative outer membrane or exported protein; Similar to E. coli putative sugar hydrolase (AAC75461.1); Blastp hit to AAC75461.1 (254 aa), 34% identity in aa 2 - 254. (253 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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