STRINGSTRING
yaaJ yaaJ yaaH yaaH nhaA nhaA STM0042 STM0042 citP citP caiT caiT kefC kefC STM0149 STM0149 kdgT kdgT yadQ yadQ ampG ampG ybaL ybaL ybbL ybbL kdgT2 kdgT2 citA citA potE potE ybgH ybgH mdfA mdfA STM1003 STM1003 putP putP STM1128 STM1128 ydjN ydjN STM1368 STM1368 ydhE ydhE ydgR ydgR ydgF ydgF ydgE ydgE STM1556 STM1556 narU narU STM1653 STM1653 narK narK chaA chaA ychM ychM ycgO ycgO nhaB nhaB yeeO yeeO STM2198 STM2198 fruA fruA setB setB bcr bcr glpT glpT pgtP pgtP mntH mntH nupC nupC cysZ cysZ hcaT hcaT yjdL yjdL ygeD ygeD araE araE galP galP nupG nupG ygjU ygjU tdcC tdcC STM3255 STM3255 yrbG yrbG nanT nanT panF panF kefB kefB pitA pitA yhiP yhiP dctA dctA lldP lldP gltS gltS yicJ yicJ yicM yicM uhpT uhpT uhpC uhpC STM3792 STM3792 pstB pstB pstA pstA pstC pstC STM3858 STM3858 kup kup tatC tatC trkH trkH yihO yihO yihP yihP rhaT rhaT yiiP yiiP STM4065 STM4065 frwC frwC yjbB yjbB dinF dinF yjcE yjcE yjcG yjcG gltP gltP proP proP yjdE yjdE melB melB STM4418 STM4418 STM4419 STM4419 yjiO yjiO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yaaJAGCS family; similar to E. coli inner membrane transport protein (AAC73118.1); Blastp hit to AAC73118.1 (476 aa), 76% identity in aa 1 - 476. (476 aa)
yaaHPutative regulatory protein; Similar to E. coli orf, hypothetical protein (AAC73121.1); Blastp hit to AAC73121.1 (188 aa), 90% identity in aa 1 - 188. (188 aa)
nhaANhaA family of transport protein, Na+/H antiporter, pH dependent; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (388 aa)
STM0042Putative sodium galactoside symporter; Similar to E. coli putative permease (AAC76681.1); Blastp hit to AAC76681.1 (479 aa), 29% identity in aa 22 - 457. (457 aa)
citPPutative citrate-sodium symport; Uptake of citrate across the boundary membrane with the concomitant uptake of a sodium ion (symport system); Belongs to the sodium:citrate (SCF) symporter family. (446 aa)
caiTPutative BCCT family betaine/carnitine/choline transport protein; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. (505 aa)
kefCCPA2 family K+ efflux antiporter, glutathione-regulated; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (620 aa)
STM0149Putative permease of the Na+:galactoside symporter family; Hypothetical protein (gi|7688349). (468 aa)
kdgT2-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (317 aa)
yadQPutative ClC family chlorine transport protein; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. (473 aa)
ampGMFS family, muropeptide transporter; Similar to E. coli regulates beta-lactamase synthesis (AAC73536.1); Blastp hit to AAC73536.1 (491 aa), 91% identity in aa 1 - 490. (491 aa)
ybaLSimilar to E. coli putative transport protein (AAC73580.1); Blastp hit to AAC73580.1 (558 aa), 94% identity in aa 1 - 556; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (558 aa)
ybbLPutative ABC-type sugar/spermidine/putrescine transport system, ATPase component; Similar to E. coli putative ATP-binding component of a transport system (AAC73592.1); Blastp hit to AAC73592.1 (225 aa), 74% identity in aa 1 - 225. (225 aa)
kdgT2Putative permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (317 aa)
citACitrate-proton symporter; Uptake of citrate across the boundary membrane with the concomitant transport of protons into the cell (symport system) (Probable). Allows the utilization of citrate as a sole source of carbon and energy upon expression in E.coli. Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. (434 aa)
potEAPC family, putrescine/ornithine antiporter; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (439 aa)
ybgHPutative POT family transport protein; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. (493 aa)
mdfAMultidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406. (410 aa)
STM1003Putative transcriptional regulator, Lrp family; Similar to E. coli inner membrane transport protein (AAC73118.1); Blastp hit to AAC73118.1 (476 aa), 30% identity in aa 12 - 430. (478 aa)
putPSSS family major sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (502 aa)
STM1128Similar to E. coli putative cotransporter (AAC76702.1); Blastp hit to AAC76702.1 (571 aa), 22% identity in aa 7 - 478; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (498 aa)
ydjNKinase-like protein; Putative domain shared with transporter; similar to E. coli part of a kinase (AAC74799.1); Blastp hit to AAC74799.1 (463 aa), 96% identity in aa 1 - 462; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (463 aa)
STM1368Putative Na+-dicarboxylate symporter; Similar to E. coli part of a kinase (AAC74799.1); Blastp hit to AAC74799.1 (463 aa), 46% identity in aa 6 - 444; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (448 aa)
ydhEPutative MATE family transport protein; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. (457 aa)
ydgRPutative POT family peptide transport protein; Proton-dependent permease that transports di- and tripeptides. (501 aa)
ydgFPutative membrane transporter of cations and cationic drugs; Catalyzes the excretion of spermidine. (120 aa)
ydgEPutative membrane transporter of cations and cationic drugs; Catalyzes the excretion of spermidine. (109 aa)
STM1556Putative Na+/H+ antiporter; Similar to E. coli transport of dicarboxylates (AAC73722.1); Blastp hit to AAC73722.1 (461 aa), 23% identity in aa 36 - 414. (483 aa)
narUMFS superfamily nitrate extrusion protein; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane; Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family. (462 aa)
STM1653Putative membrane transporter of cations; Similar to E. coli methylviologen resistance (AAC73644.1); Blastp hit to AAC73644.1 (110 aa), 59% identity in aa 5 - 110. (112 aa)
narKSimilar to E. coli nitrite extrusion protein (AAC74307.1); Blastp hit to AAC74307.1 (463 aa), 94% identity in aa 1 - 462. (465 aa)
chaASimilar to E. coli sodium-calcium/proton antiporter (AAC74300.1); Blastp hit to AAC74300.1 (366 aa), 93% identity in aa 1 - 366. (366 aa)
ychMPutative SulP family transport protein; Similar to E. coli orf, hypothetical protein (AAC74290.1); Blastp hit to AAC74290.1 (550 aa), 93% identity in aa 1 - 550. (553 aa)
ycgOPutative CPA1 family Na:H transport protein; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (577 aa)
nhaBNhaB family of transport protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. (514 aa)
yeeOPutative MATE family transport protein; Similar to E. coli orf, hypothetical protein (AAC75048.1); Blastp hit to AAC75048.1 (547 aa), 82% identity in aa 53 - 533. (485 aa)
STM2198Putative regulatory protein; Similar to E. coli regulator of uhpT (AAC76690.1); Blastp hit to AAC76690.1 (440 aa), 39% identity in aa 5 - 428. (440 aa)
fruAFructose-specific transport protein; Sugar Specific PTS system; similar to E. coli PTS system, fructose-specific transport protein (AAC75228.1); Blastp hit to AAC75228.1 (563 aa), 92% identity in aa 1 - 563. (562 aa)
setBProton efflux pump; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose (By similarity); Belongs to the major facilitator superfamily. Set transporter family. (393 aa)
bcrBicyclomycin resistance protein; MFS family multidrug transport protein; similar to E. coli bicyclomycin resistance protein; transmembrane protein (AAC75243.1); Blastp hit to AAC75243.1 (396 aa), 93% identity in aa 1 - 396. (396 aa)
glpTMFS family, sn-glycerol-3-phosphate transport protein; Similar to E. coli sn-glycerol-3-phosphate permease (AAC75300.1); Blastp hit to AAC75300.1 (452 aa), 96% identity in aa 1 - 452. (452 aa)
pgtPTransporter protein; The phosphoglycerate transporter protein is a part of the PGT transport system. It is the membrane bound transporter for phosphoglycerate into salmonella. (463 aa)
mntHManganese/divalent cation transport protein; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake; Belongs to the NRAMP family. (413 aa)
nupCNUP family nucleoside transport protein; Similar to E. coli permease of transport system for 3 nucleosides (AAC75452.1); Blastp hit to AAC75452.1 (400 aa), 98% identity in aa 1 - 400; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (400 aa)
cysZRequired for sulfate transport; Possibly involved in sulfate transport. (253 aa)
hcaTSimilar to E. coli MFS (major facilitator superfamily) transporter (AAC75589.1); Blastp hit to AAC75589.1 (379 aa), 88% identity in aa 1 - 376. (379 aa)
yjdLPutative POT family, di-/tripeptide transport protein; Similar to E. coli putative peptide transporter (AAC77091.1); Blastp hit to AAC77091.1 (485 aa), 80% identity in aa 1 - 484. (486 aa)
ygeDPutative efflux protein; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. (400 aa)
araEL-arabinose: proton symport protein; Low-affinity transporter;MFS family; similar to E. coli low-affinity L-arabinose transport system proton symport protein (AAC75880.1); Blastp hit to AAC75880.1 (472 aa), 97% identity in aa 1 - 472; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (472 aa)
galPMFS family galactose:proton symporter; Similar to E. coli galactose-proton symport of transport system (AAC75980.1); Blastp hit to AAC75980.1 (464 aa), 97% identity in aa 1 - 464; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (464 aa)
nupGMFS family nucleoside transport; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (418 aa)
ygjUPutative dicarboxylate permease; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (414 aa)
tdcCHAAAP family L-threonine/ L-serine permease; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. (443 aa)
STM3255Putative phosphotransferase system fructose-specific component IIB; Similar to E. coli PTS system, fructose-specific transport protein (AAC75228.1); Blastp hit to AAC75228.1 (563 aa), 42% identity in aa 104 - 562, 32% identity in aa 2 - 41. (475 aa)
yrbGPutative CacA family Na:Ca transport protein; Similar to E. coli orf, hypothetical protein (AAC76228.1); Blastp hit to AAC76228.1 (325 aa), 87% identity in aa 1 - 324. (325 aa)
nanTMFS family sialic acid transport protein; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (496 aa)
panFSimilar to E. coli sodium/pantothenate symporter (AAC76290.1); Blastp hit to AAC76290.1 (485 aa), 93% identity in aa 3 - 485; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (483 aa)
kefBCPA2 family K+:H+ antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (601 aa)
pitAPiT family; similar to E. coli low-affinity phosphate transport (AAC76518.1); Blastp hit to AAC76518.1 (499 aa), 92% identity in aa 1 - 499. (498 aa)
yhiPPutative POT family peptide transport protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa)
dctADAACS family C4-dicarboxylic acids transport protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (428 aa)
lldPLctP transporter; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force (By similarity). (551 aa)
gltSGltS family glutamate transport protein; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. (401 aa)
yicJPutative GPH family transport protein; Similar to E. coli putative permease (AAC76681.1); Blastp hit to AAC76681.1 (479 aa), 91% identity in aa 20 - 479. (460 aa)
yicMPutative MFS family tranport protein; Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine; Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily. (397 aa)
uhpTMFS family hexose phosphate transport protein; Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. (463 aa)
uhpCRegulator of uhpT expression; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. (442 aa)
STM3792Putative L-fucose permease; Similar to E. coli fucose permease (AAC75843.1); Blastp hit to AAC75843.1 (438 aa), 34% identity in aa 17 - 428. (438 aa)
pstBHigh-affinity phosphate transporter; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (257 aa)
pstAABC superfamily (membrane); similar to E. coli high-affinity phosphate-specific transport system (AAC76749.1); Blastp hit to AAC76749.1 (296 aa), 95% identity in aa 1 - 296. (296 aa)
pstCHigh-affinity phosphate transporter; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (319 aa)
STM3858Putative phosphotransferase system fructose-specific component IIB; Similar to E. coli PTS system, fructose-specific transport protein (AAC75228.1); Blastp hit to AAC75228.1 (563 aa), 66% identity in aa 104 - 552. (457 aa)
kupKUP family low affinity potassium transport system; Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system); Belongs to the HAK/KUP transporter (TC 2.A.72) family. (622 aa)
tatCComponent of sec-independent protein export; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (259 aa)
trkHTrk family potassium transport protein; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA and requires TrkE for transport activity (By similarity); Belongs to the TrkH potassium transport family. (483 aa)
yihOPutative GPH family transport protein; Could be involved in sulfoquinovose import; Belongs to the sodium:galactoside symporter (TC 2.A.2) family. (473 aa)
yihPPutative GPH family transport protein; Could be involved in the export of 2,3-dihydroxypropane-1- sulfonate (DHPS); Belongs to the sodium:galactoside symporter (TC 2.A.2) family. (460 aa)
rhaTDMT Superfamily L-rhamnose:H+ symporter protein; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system); Belongs to the L-rhamnose transporter (TC 2.A.7.6) family. (344 aa)
yiiPPutative CDF family transport protein; Cation-efflux transporter that may have a role in detoxification. (300 aa)
STM4065Putative permease of the Na+:galactoside symporter family; Hypothetical protein (gi|7688349). (444 aa)
frwCSimilar to E. coli PTS system, fructose-like enzyme II component (AAC76931.1); Blastp hit to AAC76931.1 (359 aa), 93% identity in aa 1 - 359. (359 aa)
yjbBPutative PNaS family transport protein; Hypothetical protein in metH-pepE intergenic region. (SW:YJBB_SALTY). (543 aa)
dinFDNA-damage-inducible protein F; Induced by UV and mitomycin C; SOS, lexA regulon; similar to E. coli DNA-damage-inducible protein F (AAC77014.1); Blastp hit to AAC77014.1 (459 aa), 89% identity in aa 19 - 457. (441 aa)
yjcEPutative CPA1 family Na:H transport protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (548 aa)
yjcGPutative SSS family transport protein; Transports acetate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (549 aa)
gltPDAACS family glutamate:aspartate symport protein; Catalyzes the proton-dependent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. (436 aa)
proPMFS family low-affinity proline transporter; Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response (By similarity); Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. (500 aa)
yjdEPutative APC family putrescine/ornithine transport protein; Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (445 aa)
melBGPH family melibiose permease II; Responsible for melibiose transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system); Belongs to the sodium:galactoside symporter (TC 2.A.2) family. (476 aa)
STM4418Sugar (and other) transporter; Similar to E. coli xylose-proton symport (AAC77001.1); Blastp hit to AAC77001.1 (491 aa), 41% identity in aa 58 - 487, 47% identity in aa 5 - 103; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
STM4419Sugar (and other) transporter; Similar to E. coli xylose-proton symport (AAC77001.1); Blastp hit to AAC77001.1 (491 aa), 33% identity in aa 58 - 486, 39% identity in aa 3 - 106; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa)
yjiOSimilar to E. coli putative transport protein (AAC77293.1); Blastp hit to AAC77293.1 (410 aa), 86% identity in aa 3 - 410. (413 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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