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kdsB kdsB ribF ribF citX2 citX2 polB polB pcnB pcnB dapD dapD glnD glnD cdsA cdsA dnaE dnaE dnaQ dnaQ dinP dinP yaiC yaiC thiI thiI dnaX dnaX entE entE citX citX nadD nadD holA holA galT galT moeB moeB STM0901 STM0901 holB holB aadA aadA yeaJ yeaJ ydiU ydiU STM1650 STM1650 galU galU holE holE fliA fliA dgcQ dgcQ umuC umuC cobU cobU rfbM rfbM rfbF rfbF rfbA rfbA galF galF manC manC srmB srmB yfiN yfiN ispD ispD cysN cysN cysD cysD rfaE rfaE glnE glnE cca cca dnaG dnaG pnp pnp rpoN rpoN yrdC yrdC rpoA rpoA fic fic glgC glgC yibT yibT kdtB kdtB rph rph rpoZ rpoZ dnaN dnaN STM3846 STM3846 glmU glmU rffH rffH mobB mobB mobA mobA polA polA rpoB rpoB rpoC rpoC thiF thiF holC holC STM4551 STM4551 holD holD lplA lplA nadR nadR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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kdsBCTP:CMP-3-deoxy-D-manno-octulosonate transferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa)
ribFFlavokinase and FAD synthetase; Similar to E. coli putative regulator (AAC73136.1); Blastp hit to AAC73136.1 (313 aa), 89% identity in aa 1 - 309; Belongs to the ribF family. (312 aa)
citX2Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73715.1); Blastp hit to AAC73715.1 (183 aa), 46% identity in aa 12 - 167. (183 aa)
polBDNA polymerase II; 3'->5' exonuclease; similar to E. coli DNA polymerase II (AAC73171.1); Blastp hit to AAC73171.1 (783 aa), 89% identity in aa 1 - 783. (783 aa)
pcnBpoly(A) polymerase I; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (472 aa)
dapDSimilar to E. coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (AAC73277.1); Blastp hit to AAC73277.1 (274 aa), 97% identity in aa 1 - 274; Belongs to the transferase hexapeptide repeat family. (274 aa)
glnDUridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (890 aa)
cdsASimilar to E. coli CDP-diglyceride synthetase (AAC73286.1); Blastp hit to AAC73286.1 (249 aa), 95% identity in aa 1 - 249; Belongs to the CDS family. (285 aa)
dnaEDNA polymerase III, alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase; Belongs to the DNA polymerase type-C family. DnaE subfamily. (1160 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contains the editing function and is a proofreading 3'- 5' exonuclease (By similarity). (243 aa)
dinPDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa)
yaiCPutative diguanylate cyclase/phosphodiesterase domain 1; Similar to E. coli orf, hypothetical protein (AAC73488.1); Blastp hit to AAC73488.1 (371 aa), 75% identity in aa 1 - 371. (370 aa)
thiISulfur transfer protein (from cys to ThiS and from IscS to U8-tRNA); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
dnaXDNA polymerase III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity). [Isoform gamma]: chain seems to interact with the delta subunit to transfer the beta subunit on the DNA; Belongs to the DnaX/STICHEL family. (642 aa)
entESimilar to E. coli 2,3-dihydroxybenzoate-AMP ligase (AAC73695.1); Blastp hit to AAC73695.1 (536 aa), 86% identity in aa 1 - 534. (536 aa)
citXPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73715.1); Blastp hit to AAC73715.1 (183 aa), 75% identity in aa 1 - 179. (183 aa)
nadDPutative nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (213 aa)
holASimilar to E. coli DNA polymerase III, delta subunit (AAC73741.1); Blastp hit to AAC73741.1 (343 aa), 89% identity in aa 1 - 343. (343 aa)
galTGalactose-1-phosphate uridylyltransferase. (SW:GAL7_SALTY). (348 aa)
moeBMolybdopterin biosynthesis; Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD. (249 aa)
STM0901Fels-1 putative prophage DNA primase. (322 aa)
holBSimilar to E. coli DNA polymerase III, delta prime subunit (AAC74183.1); Blastp hit to AAC74183.1 (334 aa), 79% identity in aa 1 - 334. (334 aa)
aadAAminoglycoside adenyltransferase; Mediates bacterial resistance to the antibiotics streptomycin and spectomycin. (262 aa)
yeaJPutative methyl-accepting chemotaxis protein; Diguanylate cyclase/phosphodiesterase domain 1; similar to E. coli orf, hypothetical protein (AAC74856.1); Blastp hit to AAC74856.1 (556 aa), 68% identity in aa 61 - 556. (497 aa)
ydiUPutative cytoplasmic protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). (480 aa)
STM1650Putative reverse transcriptase. (99 aa)
galUSimilar to E. coli glucose-1-phosphate uridylyltransferase (AAC74318.1); Blastp hit to AAC74318.1 (302 aa), 97% identity in aa 1 - 302. (302 aa)
holESimilar to E. coli DNA polymerase III, theta subunit (AAC74912.1); Blastp hit to AAC74912.1 (76 aa), 88% identity in aa 1 - 76. (76 aa)
fliASigma F (sigma 28) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. May regulate the expression of genes involved in virulence. (239 aa)
dgcQPutative inner membrane protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity). (570 aa)
umuCError-prone repair protein; Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template. (422 aa)
cobUCobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. Belongs to the CobU/CobP family. (181 aa)
rfbMMannose-1-phosphate guanylyltransferase; Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen; Belongs to the mannose-6-phosphate isomerase type 2 family. (479 aa)
rfbFGlucose-1-phosphate cytidylyltransferase; Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate (By similarity). (257 aa)
rfbAdTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Is also able to convert non natural substrates such as a wide array of alpha-D- hexopyranosyl, deoxy-alpha-D-glucopyranosyl, aminodeoxy-alpha-D- hexopyranosyl and acetamidodeoxy-alpha-D-hexopyranosyl phosphates to their corresponding dTDP- and UDP-nucleotide sugars. (292 aa)
galFPutative glucose-1-phosphate uridylyltransferase, non-catalytic subunit; May play a role in stationary phase survival; Belongs to the UDPGP type 2 family. (297 aa)
manCMannose-1-phosphate; Involved in the biosynthesis of the capsular polysaccharide colanic acid. (480 aa)
srmBATP-dependent RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily. (444 aa)
yfiNPutative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC75653.1); Blastp hit to AAC75653.1 (408 aa), 75% identity in aa 2 - 405. (406 aa)
ispD4-phosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (236 aa)
cysNATP-sulfurylase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (479 aa)
cysDATP-sulfurylase, subunit 1; Similar to E. coli ATP:sulfurylase (ATP:sulfate adenylyltransferase), subunit 2 (AAC75794.1); Blastp hit to AAC75794.1 (302 aa), 97% identity in aa 1 - 302. (302 aa)
rfaEPutative sugar nucleotide transferase domain of ADP-L-glycero-D-manno-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
glnEAdenylyl transferase for glutamine synthetase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal trans [...] (947 aa)
ccatRNA nucleotidyl transferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (413 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (581 aa)
pnpPolynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. Is a global regulator of virulence and persistency. (711 aa)
rpoNSigma N factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC). (477 aa)
yrdCPutative translation factor; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (190 aa)
rpoARNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa)
ficPutative cell filamentation protein; Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP. (200 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (431 aa)
yibTPutative cytoplasmic protein. (69 aa)
kdtBPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
rphRNase PH; Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates. (238 aa)
rpoZRNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (91 aa)
dnaNDNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa)
STM3846Putative reverse transcriptase; RNA-dependent DNA polymerase. (289 aa)
glmUN-acetyl glucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa)
rffHSimilar to E. coli glucose-1-phosphate thymidylyltransferase (AAC76794.1); Blastp hit to AAC76794.1 (293 aa), 95% identity in aa 240 - 24. (74 aa)
mobBGTP-binding; similar to E. coli molybdopterin-guanine dinucleotide biosynthesis protein B (AAC76854.1); Blastp hit to AAC76854.1 (170 aa), 77% identity in aa 1 - 167. (171 aa)
mobAPutative molybdopterin-guanine dinucleotide biosynthesis protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template. (928 aa)
rpoBRNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1342 aa)
rpoCRNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1407 aa)
thiFThiamin biosynthesis protein, thiazole moiety; Catalyzes the adenylation of thisS as part of thiazole synthesis; with ThiI it catalyses the transfer of sulfur from cysteine to the ThiS enzyme; similar to E. coli thiamin biosynthesis, thiazole moiety (AAC76966.1); Blastp hit to AAC76966.1 (245 aa), 84% identity in aa 1 - 245. (252 aa)
holCSimilar to E. coli DNA polymerase III, chi subunit (AAC77216.1); Blastp hit to AAC77216.1 (147 aa), 95% identity in aa 1 - 147. (160 aa)
STM4551Putative diguanylate cyclase/phosphodiesterase domain 1 containing protein; Similar to E. coli orf, hypothetical protein (AAC74110.1); Blastp hit to AAC74110.1 (452 aa), 41% identity in aa 274 - 444, 24% identity in aa 14 - 102. (354 aa)
holDDNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (145 aa)
lplALipoate-protein ligase A; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. (338 aa)
nadRTrifunctional protein; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the A [...] (410 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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