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cheZ cheZ apaH apaH yaeD yaeD phoR phoR pgpA pgpA cof cof ushA ushA STM0561 STM0561 cobC cobC nagD nagD ybhA ybhA ybiV(2) ybiV(2) ybiV(1) ybiV(1) STM0867 STM0867 sopB sopB agp agp ycdX ycdX phoQ phoQ pgpB pgpB trpH trpH prpA prpA STM0033 STM0033 gpmB gpmB serB serB yjjG yjjG fbp fbp cysQ cysQ cpdB cpdB phoN phoN aphA aphA aceK aceK STM4104 STM4104 glpX glpX STM4010 STM4010 yigL yigL yigB yigB yidA yidA uhpB uhpB STM3595 STM3595 yrfG yrfG gph gph yrbI yrbI cca cca surE surE pphB pphB sptP sptP yqaB yqaB suhB suhB sixA sixA yfbT yfbT yfbR yfbR ais ais STM2197 STM2197 wzb wzb yedP yedP hisB hisB otsB otsB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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cheZChemotactic response protein; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). Acts on free CheY-P. Belongs to the CheZ family. (214 aa)
apaHDiadenosine tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (282 aa)
yaeDPutative dehydratase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family. (188 aa)
phoRSensory kinase in two-component regulatory system with PhoB, regulates pho regulon; Similar to E. coli positive and negative sensor protein for pho regulon (AAC73503.1); Blastp hit to AAC73503.1 (431 aa), 90% identity in aa 1 - 431. (431 aa)
pgpAPhosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (171 aa)
cofPutative hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). (272 aa)
ushAUDP-sugar hydrolase 5'-nucleotidase; Silent protein USHA(0) precursor. (SW:USHA_SALTY); Belongs to the 5'-nucleotidase family. (550 aa)
STM0561Sensor protein; Similar to E. coli putative 2-component sensor protein (AAC73671.1); Blastp hit to AAC73671.1 (480 aa), 74% identity in aa 375 - 479. (109 aa)
cobCAlpha ribazole-5'-P phosphatase in cobalamin synthesis; Catalyzes the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12); involved in the assembly of the nucleotide loop of cobalamin. Also catalyzes the hydrolysis of the phospho group from alpha-ribazole 5'-phosphate to form alpha-ribazole. (202 aa)
nagDSimilar to E. coli N-acetylglucosamine metabolism (AAC73769.1); Blastp hit to AAC73769.1 (250 aa), 96% identity in aa 1 - 250. (250 aa)
ybhAPutative hydrolase of the HAD superfamily; Similar to E. coli putative phosphatase (AAC73853.1); Blastp hit to AAC73853.1 (272 aa), 84% identity in aa 1 - 272. (272 aa)
ybiV(2)Putative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC73909.1); Blastp hit to AAC73909.1 (271 aa), 94% identity in aa 33 - 269. (239 aa)
ybiV(1)Putative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC73909.1); Blastp hit to AAC73909.1 (271 aa), 88% identity in aa 1 - 269. (269 aa)
STM0867Putative hydrolase; Similar to E. coli orf, hypothetical protein (AAC73931.1); Blastp hit to AAC73931.1 (262 aa), 82% identity in aa 1 - 261. (271 aa)
sopBPathogenicity island encoded protein: SPI5; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulti [...] (561 aa)
agpGlucose-1-phosphatase precursor. (SW:AGP_SALTY). (413 aa)
ycdXPutative Histidinol phosphatase; Related to hydrolases of the PHP family; similar to E. coli orf, hypothetical protein (AAC74118.1); Blastp hit to AAC74118.1 (245 aa), 89% identity in aa 1 - 245. (245 aa)
phoQSensory kinase protein in two-component regulatory system with PhoP; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane- associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of [...] (487 aa)
pgpBSimilar to E. coli non-essential phosphatidylglycerophosphate phosphatase, membrane bound (AAC74360.1); Blastp hit to AAC74360.1 (254 aa), 82% identity in aa 1 - 254. (254 aa)
trpHtrpR controlled transcriptional unit in the 5' upstream region of the trp operon; Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency lower than that of the corresponding single-stranded oligonucleotides. (293 aa)
prpASerine/threonine protein phosphatase; Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown. (216 aa)
STM0033Putative 5'-nucleotidase; Similar to E. coli UDP-sugar hydrolase (5'-nucleotidase) (AAC73582.1); Blastp hit to AAC73582.1 (550 aa), 26% identity in aa 1 - 253, 32% identity in aa 386 - 506; Belongs to the 5'-nucleotidase family. (523 aa)
gpmBSimilar to E. coli phosphoglyceromutase 2 (AAC77348.1); Blastp hit to AAC77348.1 (215 aa), 91% identity in aa 1 - 215; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
serBSimilar to E. coli 3-phosphoserine phosphatase (AAC77341.1); Blastp hit to AAC77341.1 (322 aa), 93% identity in aa 1 - 322. (322 aa)
yjjGPutative haloacid dehalogenase-like hydrolase; Similar to E. coli putative phosphatase (AAC77327.1); Blastp hit to AAC77327.1 (225 aa), 91% identity in aa 1 - 225. (226 aa)
fbpSimilar to E. coli fructose-bisphosphatase (AAC77189.1); Blastp hit to AAC77189.1 (332 aa), 97% identity in aa 1 - 332. (332 aa)
cysQCysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. (246 aa)
cpdB2',3'-cyclic-nucleotide 2'-phosphodiesterase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5'-nucleotidase family. (647 aa)
phoNNonspecific acid phosphatase precursor. (SW:PHON_SALTY). (250 aa)
aphANon-specific acid phosphatase/phosphotransferase, class B; Dephosphorylates several organic phosphate monoesters such as 3'-UMP, 5'-UMP and pNPP. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds such as the 2'-, 3-, or 5'-hydroxyls of nucleosides and nucleotides. Also displays significant phosphomutase activity since it is able to catalyze the transfer of the phosphate group of 3'-AMP from the 3'-position both to the 2'- and 5'-positions. One of the physio [...] (237 aa)
aceKIsocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (583 aa)
STM4104Putative 5'-nucleotidase; Related esterase; similar to E. coli UDP-sugar hydrolase (5'-nucleotidase) (AAC73582.1); Blastp hit to AAC73582.1 (550 aa), 25% identity in aa 34 - 253, 28% identity in aa 383 - 506; 2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. (518 aa)
glpXSimilar to E. coli unknown function in glycerol metabolism (AAC76907.1); Blastp hit to AAC76907.1 (336 aa), 94% identity in aa 1 - 336. (336 aa)
STM4010Similar to E. coli putative phosphatase (AAC73853.1); Blastp hit to AAC73853.1 (272 aa), 44% identity in aa 147 - 267, 30% identity in aa 1 - 169. (244 aa)
yigLPutative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC76829.1); Blastp hit to AAC76829.1 (171 aa), 85% identity in aa 1 - 167. (266 aa)
yigBPutative hydrolase of the HAD superfamily; Similar to E. coli putative phosphatase (AAC76815.1); Blastp hit to AAC76815.1 (238 aa), 87% identity in aa 1 - 238. (238 aa)
yidAPutative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC76720.1); Blastp hit to AAC76720.1 (270 aa), 93% identity in aa 1 - 270. (281 aa)
uhpBSensory histidine kinase in two-component regulatory sytem with UhpA; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA. (500 aa)
STM3595Putative phosphatase. (423 aa)
yrfGSimilar to E. coli putative phosphatase (AAC76424.1); Blastp hit to AAC76424.1 (237 aa), 85% identity in aa 16 - 237. (222 aa)
gphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (252 aa)
yrbIPutative protein of HAD superfamily; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (188 aa)
ccatRNA nucleotidyl transferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (413 aa)
surESurvival protein, protein damage control; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (253 aa)
pphBSerine/threonine specific protein phosphatase 2; Can hydrolyze phosphorylated Ser-, Thr- or Tyr-substrates in vitro. The natural substrate is unknown. (218 aa)
sptPProtein tyrosine phosphate; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear. In the N-terminal section; belongs to the YopE family. (543 aa)
yqaBSimilar to E. coli putative phosphatase (AAC75737.1); Blastp hit to AAC75737.1 (188 aa), 87% identity in aa 1 - 188. (188 aa)
suhBInositol monophosphatase; Similar to E. coli enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action (AAC75586.1); Blastp hit to AAC75586.1 (267 aa), 97% identity in aa 1 - 267; Belongs to the inositol monophosphatase superfamily. (267 aa)
sixAPhosphohistidine phosphatase; Similar to E. coli orf, hypothetical protein (AAC75400.1); Blastp hit to AAC75400.1 (161 aa), 89% identity in aa 1 - 161. (161 aa)
yfbTSimilar to E. coli putative phosphatase (AAC75353.1); Blastp hit to AAC75353.1 (222 aa), 86% identity in aa 1 - 221. (225 aa)
yfbRPutative hydrolase of HD superfamily; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa)
aisAluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. (201 aa)
STM2197Similar to E. coli 3-phosphoserine phosphatase (AAC77341.1); Blastp hit to AAC77341.1 (322 aa), 39% identity in aa 111 - 305. (295 aa)
wzbPutative protein-tyrosine-phosphatase; Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI). (149 aa)
yedPPutative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC75021.1); Blastp hit to AAC75021.1 (271 aa), 75% identity in aa 1 - 269. (271 aa)
hisBImidazole glycerol-phosphate dehydratase; Bifunctional; histidine biosynthesis bifunctional protein HISB [includes:histidinol-phosphatase ]. (SW:HIS7_SALTY); In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (355 aa)
otsBTrehalose-6-phosphate phophatase, biosynthetic; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (267 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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