STRINGSTRING
STM2358 STM2358 yfbQ yfbQ yfbE yfbE rfbH rfbH hisC hisC dadX dadX ydcR ydcR STM1557 STM1557 sufS sufS astC astC pabC pabC csdA csdA lysA lysA gcvP gcvP yggS yggS speC speC metC metC thrC thrC hemL hemL ybdL ybdL cobD cobD oat oat tdcB tdcB argD argD malP malP speF speF bioA bioA bioF bioF serC serC glgP glgP avtA avtA kbl kbl dsdA dsdA ilvA ilvA wecE wecE yiiM yiiM metB metB aspC aspC dpaL dpaL STM1060 STM1060 STM2803 STM2803 alr alr adi adi tyrB tyrB gabT gabT glyA glyA nifS nifS ptsJ ptsJ yfdZ yfdZ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
STM2358Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76406.1); Blastp hit to AAC76406.1 (387 aa), 27% identity in aa 33 - 293. (367 aa)
yfbQPutative regulator; similar to E. coli putative aminotransferase (AAC75350.1); Blastp hit to AAC75350.1 (405 aa), 96% identity in aa 1 - 404. (404 aa)
yfbEPutative DegT/DnrJ/EryC1/StrS family; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity); Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (385 aa)
rfbHCDP-6deoxy-D-xylo-4-hexulose-3-dehydrase; LPS side chain defect; lipopolysaccharide biosynthesis protein RFBH. (SW:RFBH_SALTY); Belongs to the DegT/DnrJ/EryC1 family. (437 aa)
hisCHistidinol-phosphate aminotransferase. (SW:HIS8_SALTY); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
dadXAlanine racemase 2; Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA. (356 aa)
ydcRPutative gntR family regulatory protein; Similar to E. coli multi modular; putative transcriptional regulator; also putative ATP-binding component of a transport system (AAC74521.1); Blastp hit to AAC74521.1 (468 aa), 87% identity in aa 1 - 468. (474 aa)
STM1557Putative aminotransferase; Similar to E. coli enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase (AAC74694.1); Blastp hit to AAC74694.1 (390 aa), 33% identity in aa 3 - 382. (400 aa)
sufSSelenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)
astCSuccinylornithine transaminase; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. (408 aa)
pabCSimilar to E. coli 4-amino-4-deoxychorismate lyase (AAC74180.1); Blastp hit to AAC74180.1 (269 aa), 69% identity in aa 1 - 269. (269 aa)
csdAPutative selenocysteine lyase; Similar to E. coli orf, hypothetical protein (AAC75852.1); Blastp hit to AAC75852.1 (401 aa), 89% identity in aa 1 - 401. (401 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
gcvPGlycine cleavage complex protein P; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
yggSPutative enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (234 aa)
speCSimilar to E. coli ornithine decarboxylase isozyme (AAC76002.1); Blastp hit to AAC76002.1 (731 aa), 87% identity in aa 21 - 731. (711 aa)
metCCystathionine beta-lyase; Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis. (395 aa)
thrCSimilar to E. coli threonine synthase (AAC73115.1); Blastp hit to AAC73115.1 (428 aa), 93% identity in aa 1 - 428. (428 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (SW:GSA_SALTY). (426 aa)
ybdLSimilar to E. coli putative aminotransferase (AAC73701.1); Blastp hit to AAC73701.1 (386 aa), 85% identity in aa 1 - 386. (386 aa)
cobDPutative aminotransferase in cobalamin synthesis; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. (364 aa)
oatPutative acetylornithine aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (429 aa)
tdcBThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to yield pyruv [...] (329 aa)
argDAcetylornithine transaminase; Involved in both the arginine and lysine biosynthetic pathways. (405 aa)
malPMaltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (797 aa)
speFSimilar to E. coli ornithine decarboxylase isozyme, inducible (AAC73787.1); Blastp hit to AAC73787.1 (732 aa), 91% identity in aa 1 - 732. (732 aa)
bioA7,8-diaminopelargonic acid synthetase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa)
bioF7-keto-8-aminopelargonic acid synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
serC3-phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
glgPGlycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (815 aa)
avtAValine-pyruvate aminotransferase; Similar to E. coli alanine-alpha-ketoisovalerate (or valine-pyruvate) transaminase, transaminase C (AAC76596.1); Blastp hit to AAC76596.1 (417 aa), 92% identity in aa 1 - 415. (416 aa)
kbl2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
dsdASimilar to E. coli D-serine dehydratase (deaminase) (AAC75425.1); Blastp hit to AAC75425.1 (442 aa), 89% identity in aa 1 - 442. (440 aa)
ilvAThreonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] (514 aa)
wecETDP-4-oxo-6-deoxy-D-glucose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
yiiMPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76892.1); Blastp hit to AAC76892.1 (234 aa), 76% identity in aa 4 - 233. (250 aa)
metBSimilar to E. coli cystathionine gamma-synthase (AAC76921.1); Blastp hit to AAC76921.1 (386 aa), 96% identity in aa 1 - 386. (386 aa)
aspCSimilar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
dpaLPutatiave diaminopropionate ammonia lyase; Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia. In vitro L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position. In vivo L-, D- and a mixure of DL-DAP allow growth. DL-DAP is toxic in the absence of this enzyme, it may inhibit enzymes involved in the synthesis of pyruvate and aspartate, as well as amino acids derived from them. (404 aa)
STM1060Putative iron-sulfur protein; Similar to E. coli orf, hypothetical protein (AAC74033.1); Blastp hit to AAC74033.1 (369 aa), 86% identity in aa 1 - 367. (369 aa)
STM2803Putative gntR family regulatory protein; Similar to E. coli putative regulator (AAC77296.1); Blastp hit to AAC77296.1 (470 aa), 31% identity in aa 119 - 437, 27% identity in aa 1 - 224. (444 aa)
alrBiosynthetic alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis. (359 aa)
adiArginine decarboxylase; Catabolic; inducible by acid; similar to E. coli biodegradative arginine decarboxylase (AAC77078.1); Blastp hit to AAC77078.1 (756 aa), 92% identity in aa 1 - 756. (756 aa)
tyrBTyrosine repressible; aromatic-amino-acid aminotransferase. (SW:TYRB_SALTY); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (397 aa)
gabTSimilar to E. coli 4-aminobutyrate aminotransferase activity (AAC75709.1); Blastp hit to AAC75709.1 (426 aa), 88% identity in aa 1 - 426; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). (417 aa)
nifSPutative aminotransferase class-V; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate; Belongs to the class-V pyridoxal-phosphate-dependent [...] (404 aa)
ptsJPutative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] (430 aa)
yfdZSimilar to E. coli putative aminotransferase (AAC75438.1); Blastp hit to AAC75438.1 (412 aa), 95% identity in aa 1 - 412. (412 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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