STRINGSTRING
ompN ompN ssaJ ssaJ ssaC ssaC lpp lpp lppB lppB spy spy mipA mipA STM1255 STM1255 pagC pagC ycfM ycfM fhuE fhuE flgI flgI flgH flgH mdoG mdoG csgG csgG STM1131 STM1131 agp agp ompA ompA STM1043 STM1043 ompF ompF dmsA dmsA lolA lolA STM0920 STM0920 artI artI artJ artJ yliB yliB ompX ompX glnH glnH ybhC ybhC modA modA ybgF ybgF pal pal ybfM ybfM gltI gltI rlpB rlpB rlpA rlpA pagP pagP fepB fepB fepA fepA fimD fimD fimC fimC ushA ushA ybaE ybaE phnS phnS tsx tsx foxA foxA STM0350 STM0350 STM0346 STM0346 stbB stbB stbC stbC stbE stbE phoE phoE pagN pagN safC safC safB safB abc abc rcsF rcsF hlpA hlpA yaeT yaeT htrA htrA stfD stfD stfC stfC fhuD fhuD fhuA fhuA stiB stiB stiC stiC gcd gcd cueO cueO yabN yabN tbpA tbpA imp imp surA surA STM0034 STM0034 STM0033 STM0033 bcfG bcfG bcfC bcfC bcfB bcfB stjB stjB osmY osmY ytfM ytfM cpdB cpdB amiB amiB STM4351 STM4351 blc blc phoN phoN STM4305 STM4305 nrfA nrfA aphA aphA lamB lamB btuB btuB STM4104 STM4104 yneA yneA cpxP cpxP yiiZ yiiZ yiiY yiiY yshA yshA pldA pldA rfe rfe rbsB rbsB STM3860 STM3860 torC torC torA torA sadA sadA yiaO yiaO yiaD yiaD bisC bisC lpfB lpfB lpfC lpfC dppA dppA STM3595 STM3595 hofQ hofQ yhbN yhbN yrbK yrbK yraP yraP yraM yraM sufI sufI STM3169 STM3169 STM3141 STM3141 mltC mltC STM3038 STM3038 STM3031 STM3031 stdB stdB stdC stdC amiC amiC nlpD nlpD invH invH invG invG prgK prgK iroN iroN STM2759 STM2759 smpA smpA yfiO yfiO rseB rseB yfhD yfhD STM2530 STM2530 yfgL yfgL sinH sinH nlpB nlpB amiA amiA yfeN yfeN pgtE pgtE fadL fadL mepA mepA argT argT hisJ hisJ ompC ompC ccmG ccmG yejA yejA cirA cirA mglB mglB yohG yohG stcB stcB stcC stcC wza wza ompS ompS fliY fliY msbB msbB prc prc emtA emtA lolB lolB ychP ychP oppA oppA tonB tonB ompW ompW sapA sapA mppA mppA STM1669 STM1669 ydcG ydcG yncD yncD nmpC nmpC STM1530 STM1530 dcp dcp STM1499 STM1499 STM1498 STM1498 slyB slyB sthA sthA sthB sthB stjC stjC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ompNOuter membrane protein N; Non-specific porin; similar to E. coli putative outer membrane protein (AAC74459.1); Blastp hit to AAC74459.1 (377 aa), 81% identity in aa 1 - 377. (377 aa)
ssaJSecretion system apparatus protein; Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB toxin. (249 aa)
ssaCSecretion system apparatus protein; SpiA (gi|1498307). (497 aa)
lppMurein lipoprotein; Plays an important role in virulence. A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non- covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (By similarity). (78 aa)
lppBPutative methyl-accepting chemotaxis protein; Plays an important role in virulence. A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non- covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (By similarity). (79 aa)
spySimilar to E. coli periplasmic protein related to spheroblast formation (AAC74813.1); Blastp hit to AAC74813.1 (161 aa), 89% identity in aa 1 - 161. (161 aa)
mipAScaffolding protein for murein-synthesizing holoenzyme; Similar to E. coli orf, hypothetical protein (AAC74852.1); Blastp hit to AAC74852.1 (248 aa), 83% identity in aa 1 - 248. (248 aa)
STM1255Putative substrate-binding protein (gi|2337942). (544 aa)
pagCReduced macrophage survival protein; Essential for full virulence and survival within macrophages; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. Ail family. (185 aa)
ycfMPutative outer membrane lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). (212 aa)
fhuEOuter membrane receptor for Fe(III)-coprogen; Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid uptake; similar to E. coli outer membrane receptor for ferric iron uptake (AAC74186.1); Blastp hit to AAC74186.1 (729 aa), 81% identity in aa 5 - 729. (724 aa)
flgIPutative flagella basal body protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (365 aa)
flgHFlagellar biosynthesis protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (232 aa)
mdoGPeriplasmic glucans biosynthesis protein; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (511 aa)
csgGPutative transcriptional regulator in curly assembly/transport, 2nd curli operon; May be involved in the biogenesis of curli organelles; Belongs to the CsgG family. (277 aa)
STM1131Putative outer membrane protein; Similar to E. coli orf, hypothetical protein (AAC77267.1); Blastp hit to AAC77267.1 (241 aa), 26% identity in aa 4 - 239. (230 aa)
agpGlucose-1-phosphatase precursor. (SW:AGP_SALTY). (413 aa)
ompAPutative membrane component hydrogenase; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage. (350 aa)
STM1043Attachment and invasion protein homolog (gi|2232362). (165 aa)
ompFOuter membrane protein 1a (ia;b;f), porin; Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2 (By similarity). (363 aa)
dmsASimilar to E. coli anaerobic dimethyl sulfoxide reductase subunit A (AAC73980.1); Blastp hit to AAC73980.1 (785 aa), 93% identity in aa 1 - 784; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (814 aa)
lolAPeriplasmic protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (204 aa)
STM0920Fels-1 prophage attachment and invasion protein; Ail and ompX homolog (gi|2232362). (172 aa)
artIArginine transport system; ABC superfamily (bind_prot); similar to E. coli arginine 3rd transport system periplasmic binding protein (AAC73950.1); Blastp hit to AAC73950.1 (243 aa), 95% identity in aa 1 - 243; Belongs to the bacterial solute-binding protein 3 family. (243 aa)
artJArginine 3rd transport system; ABC superfamily (bind_prot); similar to E. coli arginine 3rd transport system periplasmic binding protein (AAC73947.1); Blastp hit to AAC73947.1 (243 aa), 91% identity in aa 1 - 243; Belongs to the bacterial solute-binding protein 3 family. (243 aa)
yliBPutative ABC transporter periplasmic binding protein; Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione. (512 aa)
ompXOuter membrane protease, receptor for phage OX2; Similar to E. coli outer membrane protein X (AAC73901.1); Blastp hit to AAC73901.1 (171 aa), 91% identity in aa 1 - 171. (171 aa)
glnHGlutamine high-affinity transporter; ABC superfamily (bind_prot); similar to E. coli periplasmic glutamine-binding protein; permease (AAC73898.1); Blastp hit to AAC73898.1 (248 aa), 96% identity in aa 1 - 248; Belongs to the bacterial solute-binding protein 3 family. (248 aa)
ybhCSimilar to E. coli putative pectinesterase (AAC73859.1); Blastp hit to AAC73859.1 (427 aa), 86% identity in aa 1 - 427. (427 aa)
modAMolybdate transporter; ABC superfamily (peri_perm); similar to E. coli molybdate-binding periplasmic protein; permease (AAC73850.1); Blastp hit to AAC73850.1 (257 aa), 86% identity in aa 1 - 257. (257 aa)
ybgFPutative periplasmic protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (262 aa)
palTol protein required for outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (174 aa)
ybfMPutative outer membrane protein; Involved in the uptake of chitosugars. (468 aa)
gltIGlutamate/aspartate transporter; Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate. (308 aa)
rlpBA minor lipoprotein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane; Belongs to the LptE lipoprotein family. (196 aa)
rlpAA minor lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides; Belongs to the RlpA family. (381 aa)
pagPPhoPQ-activated gene; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. Required for resistance to cationic antimicrobial peptides (CAMPs). Modifications of lipid A with a palmitate chain allow to evade host immune defenses by resisting antimicrobial peptides and attenuating the inflammatory response to infection triggered by lipopolysaccharide through the Toll-like receptor 4 (TLR4) signal transduction pathway. (190 aa)
fepBABC superfamily (peri_perm); similar to E. coli ferric enterobactin (enterochelin) binding protein; periplasmic component (AAC73693.1); Blastp hit to AAC73693.1 (318 aa), 79% identity in aa 1 - 318. (318 aa)
fepASimilar to E. coli outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D (AAC73685.1); Blastp hit to AAC73685.1 (746 aa), 81% identity in aa 1 - 746. (751 aa)
fimDOuter membrane usher protein; Involved in the export and assembly of FimA fimbrial subunits across the outer membrane; Belongs to the fimbrial export usher family. (870 aa)
fimCPeriplasmic chaperone, required for type 1 fimbriae; Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH; Belongs to the periplasmic pilus chaperone family. (230 aa)
ushAUDP-sugar hydrolase 5'-nucleotidase; Silent protein USHA(0) precursor. (SW:USHA_SALTY); Belongs to the 5'-nucleotidase family. (550 aa)
ybaEPutative ABC transporter periplasmic binding protein; Similar to E. coli orf, hypothetical protein (AAC73548.1); Blastp hit to AAC73548.1 (566 aa), 79% identity in aa 1 - 565. (566 aa)
phnS2-aminoethylphosphonate transporter, periplasmic-binding component; Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import; Belongs to the bacterial solute-binding protein 1 family. (337 aa)
tsxNucleoside channel; Functions as substrate-specific channel for nucleosides and deoxynucleosides. Functions also in albicidin uptake and as receptor for colicin K; Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family. (287 aa)
foxAFerrioxamine receptor; Ferrioxamine binding and uptake, in association with the TonB protein; Belongs to the TonB-dependent receptor family. (702 aa)
STM0350Homology to outer membrane efflux protein; Similar to E. coli putative resistance protein (AAC73673.1); Blastp hit to AAC73673.1 (457 aa), 37% identity in aa 7 - 457. (503 aa)
STM0346Putative outer membrane protein; Unknown (gi|6707276). (174 aa)
stbBPutative fimbriae; Similar to E. coli probable pilin chaperone similar to PapD (AAC73251.1); Blastp hit to AAC73251.1 (246 aa), 40% identity in aa 1 - 240. (253 aa)
stbCPutative fimbriae; Similar to E. coli outer membrane protein; export and assembly of type 1 fimbriae, interrupted (AAC77273.1); Blastp hit to AAC77273.1 (878 aa), 30% identity in aa 30 - 870. (853 aa)
stbEPutative fimbriae; Similar to E. coli periplasmic chaperone, required for type 1 fimbriae (AAC77272.1); Blastp hit to AAC77272.1 (241 aa), 30% identity in aa 32 - 241. (252 aa)
phoEOuter membrane pore protein e (e,ic,nmpab); Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes; Belongs to the Gram-negative porin family. (350 aa)
pagNHomolog of sapA; Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells. (239 aa)
safCPutative fimbriae usher; Similar to E. coli putative outer membrane protein, export function (AAC73634.1); Blastp hit to AAC73634.1 (867 aa), 34% identity in aa 35 - 862. (836 aa)
safBPutative fimbriae assembly chaparone; Similar to E. coli putative chaperone (AAC76177.1); Blastp hit to AAC76177.1 (231 aa), 35% identity in aa 26 - 223. (237 aa)
abcPutative ABC superfamily (atp_bind) transport system; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
rcsFRegulator in colanic acid synthesis; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (134 aa)
hlpAHistone-like protein, located in outer membrane; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. (161 aa)
yaeTPutative outer membrane antigen; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (804 aa)
htrAPeriplasmic serine protease Do, heat shock protein; DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolyt [...] (475 aa)
stfDPeriplasmic fimbrial chaperone StfD (gi|3747031). (250 aa)
stfCOuter membrane usher protein StfC (gi|3747030). (885 aa)
fhuDHydroxamate-dependent iron uptake; ABC superfamily (bind _prot); similar to E. coli hydroxamate-dependent iron uptake, cytoplasmic membrane component (AAC73263.1); Blastp hit to AAC73263.1 (296 aa), 82% identity in aa 1 - 296. (296 aa)
fhuAIron complex outermembrane recepter protein; Similar to E. coli outer membrane protein receptor for ferrichrome, colicin M, and phages T1, T5, and phi80 (AAC73261.1); Blastp hit to AAC73261.1 (747 aa), 68% identity in aa 1 - 747. (729 aa)
stiBPutative fimbrial chaparone; Similar to E. coli periplasmic chaperone, required for type 1 fimbriae (AAC77272.1); Blastp hit to AAC77272.1 (241 aa), 39% identity in aa 20 - 235. (227 aa)
stiCPutative fimbrial usher; Similar to E. coli putative outer membrane protein (AAC76178.1); Blastp hit to AAC76178.1 (838 aa), 39% identity in aa 20 - 558, 34% identity in aa 493 - 837. (848 aa)
gcdSimilar to E. coli glucose dehydrogenase (AAC73235.1); Blastp hit to AAC73235.1 (796 aa), 92% identity in aa 1 - 796. (796 aa)
cueOPutative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). (536 aa)
yabNPutative periplasmic binding protein of transport system; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain. (552 aa)
tbpAThiamine-binding periplasmic protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Is also involved in thiamine pyrophosphate transport. (327 aa)
impOrganic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (786 aa)
surAPeptidyl-prolyl cis-trans isomerase; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (428 aa)
STM0034Putative outer membrane or exported protein; Similar to E. coli putative sugar hydrolase (AAC75461.1); Blastp hit to AAC75461.1 (254 aa), 34% identity in aa 2 - 254. (253 aa)
STM0033Putative 5'-nucleotidase; Similar to E. coli UDP-sugar hydrolase (5'-nucleotidase) (AAC73582.1); Blastp hit to AAC73582.1 (550 aa), 26% identity in aa 1 - 253, 32% identity in aa 386 - 506; Belongs to the 5'-nucleotidase family. (523 aa)
bcfGFimbrial chaperone (gi|4959517). (243 aa)
bcfCFimbrial usher; Bovine colonization factor BcfC (gi|4530570). (873 aa)
bcfBFimbrial chaperone (gi|4959512). (228 aa)
stjBSimilar to E. coli putative outer membrane protein (AAC76248.1); Blastp hit to AAC76248.1 (793 aa), 40% identity in aa 29 - 793. (802 aa)
osmYRpoS-dependent stationary phase gene; similar to E. coli hyperosmotically inducible periplasmic protein (AAC77329.1); Blastp hit to AAC77329.1 (201 aa), 89% identity in aa 1 - 201. (205 aa)
ytfMPutative outer membrane protein; Similar to E. coli orf, hypothetical protein (AAC77177.1); Blastp hit to AAC77177.1 (577 aa), 90% identity in aa 3 - 577. (577 aa)
cpdB2',3'-cyclic-nucleotide 2'-phosphodiesterase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5'-nucleotidase family. (647 aa)
amiBN-acetylmuramoyl-l-alanine amidase II; Cell-wall hydrolase involved in septum cleavage during cell division. (439 aa)
STM4351Similar to E. coli arginine 3rd transport system periplasmic binding protein (AAC73947.1); Blastp hit to AAC73947.1 (243 aa), 57% identity in aa 1 - 243; Belongs to the bacterial solute-binding protein 3 family. (246 aa)
blcOuter membrane lipoprotein; Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids. (177 aa)
phoNNonspecific acid phosphatase precursor. (SW:PHON_SALTY). (250 aa)
STM4305Similar to E. coli anaerobic dimethyl sulfoxide reductase subunit A (AAC73980.1); Blastp hit to AAC73980.1 (785 aa), 51% identity in aa 3 - 784; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (783 aa)
nrfANitrite reductase periplasmic cytochrome c(552); Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
aphANon-specific acid phosphatase/phosphotransferase, class B; Dephosphorylates several organic phosphate monoesters such as 3'-UMP, 5'-UMP and pNPP. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds such as the 2'-, 3-, or 5'-hydroxyls of nucleosides and nucleotides. Also displays significant phosphomutase activity since it is able to catalyze the transfer of the phosphate group of 3'-AMP from the 3'-position both to the 2'- and 5'-positions. One of the physio [...] (237 aa)
lamBPhage lambda receptor protein; Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages; Belongs to the porin LamB (TC 1.B.3) family. (452 aa)
btuBOuter membrane receptor for transport of vitamin B12, E colicins, and bacteriophage BF23; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. (614 aa)
STM4104Putative 5'-nucleotidase; Related esterase; similar to E. coli UDP-sugar hydrolase (5'-nucleotidase) (AAC73582.1); Blastp hit to AAC73582.1 (550 aa), 25% identity in aa 34 - 253, 28% identity in aa 383 - 506; 2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. (518 aa)
yneAPutative sugar transport protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. (340 aa)
cpxPPeriplasmic repressor of cpx regulon by interaction with CpxA; Rescue from transitory stresses; similar to E. coli orf, hypothetical protein (AAC76896.1); Blastp hit to AAC76896.1 (122 aa), 94% identity in aa 1 - 122. (166 aa)
yiiZPutative dicarboxylate-binding periplasmic protein; Hypothetical protein in sodA 5'region. (SW:YIIZ_SALTY). (327 aa)
yiiYPutative outer membrane protein; Hypothetical 15.6 Kda protein in RHAT 5'region. (SW:YIIY_SALTY). (227 aa)
yshAPutative outer membrane protein; Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is unknown (By similarity); Belongs to the oligogalacturonate-specific porin KdgM (TC 1.B.35) family. OmpL subfamily. (230 aa)
pldAOuter membrane phospholipase A; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities; Belongs to the phospholipase A1 family. (289 aa)
rfeUndecaprenyl-phosphate N-acetylglucosaminyltransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily. (367 aa)
rbsBD-ribose transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. (296 aa)
STM3860Putative dipeptide/oligopeptide/nickel ABC-type transport systems; Periplasmic component; similar to E. coli putative transport protein (AAC73180.1); Blastp hit to AAC73180.1 (551 aa), 49% identity in aa 1 - 309, 29% identity in aa 297 - 548. (585 aa)
torCTrimethylamine N-oxide reductase; Cytochrome c-type subunit; also has activity as negativer regulator of tor operon; similar to E. coli trimethylamine N-oxide reductase, cytochrome c-type subunit (AAC74081.1); Blastp hit to AAC74081.1 (390 aa), 90% identity in aa 1 - 388; Belongs to the TorC/TorY family. (394 aa)
torATrimethylamine N-oxide reductase subunit; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. (850 aa)
sadAPutative inner membrane protein; Involved in cell aggregation, biofilm formation, and adhesion to human intestinal epithelial cells; Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family. (1461 aa)
yiaOSimilar to E. coli putative solute-binding transport protein (AAC76603.1); Blastp hit to AAC76603.1 (328 aa), 87% identity in aa 1 - 328. (328 aa)
yiaDSimilar to E. coli putative outer membrane protein (AAC76576.1); Blastp hit to AAC76576.1 (219 aa), 94% identity in aa 1 - 219. (220 aa)
bisCSimilar to E. coli biotin sulfoxide reductase (AAC76575.1); Blastp hit to AAC76575.1 (739 aa), 86% identity in aa 2 - 739; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (777 aa)
lpfBLong polar fimbrial chaperone; Required for the biogenesis of long polar fimbria; binds and interact with LpfA; Belongs to the periplasmic pilus chaperone family. (232 aa)
lpfCLong polar fimbrial outer membrane usher protein; Involved in the export and assembly of LpfA fimbrial subunits across the outer membrane; Belongs to the fimbrial export usher family. (842 aa)
dppADipeptide transport protein; ABC superfamily (peri_perm); similar to E. coli dipeptide transport protein (AAC76569.1); Blastp hit to AAC76569.1 (535 aa), 93% identity in aa 1 - 535. (535 aa)
STM3595Putative phosphatase. (423 aa)
hofQPutative transport protein; Possibly in biosynthesis of type IV pilin; similar to E. coli putative transport portein (AAC76416.1); Blastp hit to AAC76416.1 (412 aa), 86% identity in aa 1 - 412. (412 aa)
yhbNPutative ABC superfamily transport protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (184 aa)
yrbKPutative inner membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (191 aa)
yraPSimilar to E. coli putative periplasmic protein (AAC76184.1); Blastp hit to AAC76184.1 (191 aa), 92% identity in aa 1 - 191. (191 aa)
yraMPutative transglycosylase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (680 aa)
sufISuppressor of ftsI; Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress. (470 aa)
STM3169Similar to E. coli putative solute-binding transport protein (AAC76603.1); Blastp hit to AAC76603.1 (328 aa), 28% identity in aa 7 - 320. (327 aa)
STM3141Molybdenum-binding periplasmic protein. (236 aa)
mltCMembrane-bound lytic murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (361 aa)
STM3038Similar to E. coli putative lipoprotein (AAC75903.1); Blastp hit to AAC75903.1 (259 aa), 84% identity in aa 8 - 259. (252 aa)
STM3031Ail and ompX-like protein; Similar to E. coli outer membrane protein X (AAC73901.1); Blastp hit to AAC73901.1 (171 aa), 29% identity in aa 1 - 171. (178 aa)
stdBSimilar to E. coli putative membrane protein (AAC76082.1); Blastp hit to AAC76082.1 (821 aa), 42% identity in aa 20 - 817. (829 aa)
stdCPutative fimbrial chaparone protein; Similar to E. coli putative chaperone (AAC73811.1); Blastp hit to AAC73811.1 (242 aa), 40% identity in aa 20 - 230. (247 aa)
amiCSimilar to E. coli putative amidase (AAC75856.1); Blastp hit to AAC75856.1 (447 aa), 94% identity in aa 31 - 446. (417 aa)
nlpDLipoprotein; Activator of the cell wall hydrolase AmiC. Required for septal murein cleavage and daughter cell separation during cell division (By similarity); Belongs to the E.coli NlpD/Haemophilus LppB family. (377 aa)
invHInvasion protein; Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Pilot protein that is required for the proper localization of the secretin InvG/SctC in the outer membrane. Required for the secretion of the Sip virulence factors. (147 aa)
invGOuter membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. (562 aa)
prgKCell invasion protein; Required for invasion of epithelial cells. Could be involved in protein secretion; Belongs to the YscJ lipoprotein family. (252 aa)
iroNTonB-dependent siderophore receptor protein; Similar to E. coli outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D (AAC73685.1); Blastp hit to AAC73685.1 (746 aa), 52% identity in aa 3 - 728, 44% identity in aa 245 - 746. (726 aa)
STM2759Putative dipeptide/oligopeptide/nickel ABC-type transport systems, periplasmic component; Similar to E. coli putative transport protein (AAC73180.1); Blastp hit to AAC73180.1 (551 aa), 27% identity in aa 19 - 545. (559 aa)
smpASmall membrane protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (112 aa)
yfiOPutative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa)
rseBAnti sigma E (sigma 24) factor, negative regulator; Similar to E. coli regulates activity of sigma-E factor (AAC75624.1); Blastp hit to AAC75624.1 (318 aa), 89% identity in aa 1 - 318. (318 aa)
yfhDPutative periplasmic amino acid binding protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (514 aa)
STM2530Similar to E. coli putative oxidoreductase, major subunit (AAC74660.1); Blastp hit to AAC74660.1 (808 aa), 42% identity in aa 15 - 807; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (801 aa)
yfgLPutative serine/threonine protein kinase; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa)
sinHSinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531). (730 aa)
nlpBLipoprotein-34; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (344 aa)
amiAN-acetylmuramoyl-l-alanine amidase I; Cell-wall hydrolase involved in septum cleavage during cell division; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. (289 aa)
yfeNPutative outer membrane protein; Similar to E. coli putative sugar hydrolase (AAC75461.1); Blastp hit to AAC75461.1 (254 aa), 85% identity in aa 1 - 254. (253 aa)
pgtEOuter membrane protein E; Protease that can cleave T7 RNA polymerase. Specific for paired basic residues; Belongs to the peptidase A26 family. (312 aa)
fadLTransport of long-chain fatty acids; Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity). Belongs to the OmpP1/FadL family. (437 aa)
mepAPenicillin-insensitive murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. Belongs to the peptidase M74 family. (274 aa)
argTLysine/arginine/ornithine transport protein; Part of an ABC transporter involved in lysine, arginine and ornithine transport. Stimulates ATPase activity of HisP. (260 aa)
hisJHistidine transport protein; Part of the histidine permease ABC transporter. Binds histidine. Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation. May have some additional function(s) in translocation that is independent of the stimulation of ATP hydrolysis. (260 aa)
ompCOuter membrane protein 1b (ib;c); Forms pores that allow passive diffusion of small molecules across the outer membrane. (378 aa)
ccmGHeme lyase/disulfide oxidoreductase; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily. (185 aa)
yejAPutative ABC transporter periplasmic binding protein; Similar to E. coli orf, hypothetical protein (AAC75238.1); Blastp hit to AAC75238.1 (606 aa), 86% identity in aa 3 - 603. (601 aa)
cirAOuter membrane porin; Receptor for colicin I; requires TonB; similar to E. coli outer membrane receptor for iron-regulated colicin I receptor; porin; requires tonB gene product (AAC75216.1); Blastp hit to AAC75216.1 (663 aa), 88% identity in aa 1 - 663. (663 aa)
mglBGalactose transport protein; This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor. (332 aa)
yohGPutative outer membrane efflux protein; Similar to E. coli putative channel/filament proteins (AAC75199.1); Blastp hit to AAC75199.1 (398 aa), 85% identity in aa 1 - 396. (478 aa)
stcBSimilar to E. coli putative chaperone (AAC75171.1); Blastp hit to AAC75171.1 (239 aa), 64% identity in aa 16 - 239. (227 aa)
stcCSimilar to E. coli putative outer membrane protein (AAC75170.1); Blastp hit to AAC75170.1 (826 aa), 74% identity in aa 1 - 826. (829 aa)
wzaPutative polysaccharide export protein; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium. (379 aa)
ompSSimilar to E. coli putative outer membrane protein (AAC74459.1); Blastp hit to AAC74459.1 (377 aa), 71% identity in aa 1 - 236, 60% identity in aa 174 - 377; Belongs to the Gram-negative porin family. (398 aa)
fliYSimilar to E. coli putative periplasmic binding transport protein (AAC74987.1); Blastp hit to AAC74987.1 (266 aa), 92% identity in aa 1 - 266; Belongs to the bacterial solute-binding protein 3 family. (266 aa)
msbBMyristoyl transferase in lipid A biosynthesis; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa)
prcCarboxy-terminal protease for penicillin-binding protein 3; Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses (By similarity). (682 aa)
emtAMembrane-bound lytic murein transglycosylase E; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. (203 aa)
lolBOuter membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (207 aa)
ychPSimilar to E. coli putative factor (AAC74304.1); Blastp hit to AAC74304.1 (417 aa), 77% identity in aa 1 - 417. (474 aa)
oppAOligopeptide transport protein with chaperone properties; This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity; Belongs to the bacterial solute-binding protein 5 family. (582 aa)
tonBTonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific en [...] (242 aa)
ompWOuter membrane protein W; Colicin S4 receptor; putative transporter; similar to E. coli putative outer membrane protein (AAC74338.1); Blastp hit to AAC74338.1 (212 aa), 88% identity in aa 1 - 212. (212 aa)
sapAABC superfamily peptide transport protein; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. Belongs to the bacterial solute-binding protein 5 family. (549 aa)
mppAPeriplasmic murein tripeptide transport protein; Also negative regulator of mulitple antibiotic resistance; similar to E. coli putative transport periplasmic protein (AAC74411.1); Blastp hit to AAC74411.1 (544 aa), 92% identity in aa 8 - 544. (537 aa)
STM1669Invasin-like protein; Homology to invasin C of Yersinia; similar to E. coli putative factor (AAC74304.1); Blastp hit to AAC74304.1 (417 aa), 30% identity in aa 38 - 403. (660 aa)
ydcGPutative periplasmic glucans biosynthesis protein; Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs); Belongs to the OpgD/OpgG family. (551 aa)
yncDSimilar to E. coli putative outer membrane receptor for iron transport (AAC74533.1); Blastp hit to AAC74533.1 (700 aa), 84% identity in aa 1 - 700. (706 aa)
nmpCNew outer membrane protein; Forms pores that allow passive diffusion of small molecules across the outer membrane; Belongs to the Gram-negative porin family. (362 aa)
STM1530Similar to E. coli putative outer membrane protein (AAC74459.1); Blastp hit to AAC74459.1 (377 aa), 61% identity in aa 2 - 377; Belongs to the Gram-negative porin family. (372 aa)
dcpDipeptidyl carboxypeptidase II; Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides. (680 aa)
STM1499Putative dimethyl sulphoxide reductase, chain A1; Similar to E. coli putative oxidoreductase, major subunit (AAC74659.1); Blastp hit to AAC74659.1 (808 aa), 86% identity in aa 1 - 808; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (813 aa)
STM1498Similar to E. coli putative oxidoreductase, major subunit (AAC74660.1); Blastp hit to AAC74660.1 (808 aa), 91% identity in aa 2 - 807; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (811 aa)
slyBOuter membrane lipoprotein SLYB precursor. (SW:SLYB_SALTY). (155 aa)
sthAPutative fimbrial chaparone protein; Similar to E. coli periplasmic chaperone, required for type 1 fimbriae (AAC77272.1); Blastp hit to AAC77272.1 (241 aa), 33% identity in aa 26 - 234. (227 aa)
sthBSimilar to E. coli putative outer membrane protein, export function (AAC73634.1); Blastp hit to AAC73634.1 (867 aa), 38% identity in aa 35 - 862. (845 aa)
stjCPutative fimbrial chaparone protein; Similar to E. coli putative chaperone (AAC76247.1); Blastp hit to AAC76247.1 (224 aa), 49% identity in aa 1 - 223. (235 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (22%) [HD]