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kdgT2 kdgT2 STM0577 STM0577 STM0576 STM0576 STM0575 STM0575 STM0574 STM0574 STM4538 STM4538 STM4537 STM4537 STM4536 STM4536 STM4535 STM4535 STM4534 STM4534 idnT idnT STM3782 STM3782 STM3773 STM3773 STM3772 STM3772 STM4448 STM4448 kdgT kdgT STM4419 STM4419 STM4418 STM4418 ptxA ptxA sgaB sgaB sgaT sgaT lamB lamB malK malK pduF pduF manZ manZ manY manY manX manX STM3783 STM3783 STM3858 STM3858 rbsA rbsA rhaT rhaT glpF glpF ptsA ptsA frwC frwC frwB frwB frwD frwD malG malG malF malF malE malE STM0571 STM0571 yadI yadI setB setB STM2342 STM2342 STM2343 STM2343 ptsH ptsH ptsI ptsI crr crr hcaT hcaT STM2570 STM2570 STM2750 STM2750 STM2751 STM2751 STM2752 STM2752 STM2758 STM2758 srlA srlA srlE srlE slrB slrB ptsP ptsP STM3134 STM3134 STM3255 STM3255 STM3256 STM3256 gatZ gatZ STM3259 STM3259 STM3260 STM3260 ptsN ptsN ptsO ptsO mtlA mtlA STM3769 STM3769 STM3770 STM3770 STM3771 STM3771 STM1614 STM1614 STM1613 STM1613 fruF fruF ydeA ydeA celC celC celB celB celA celA ptsG ptsG STM0885 STM0885 STM0884 STM0884 nagE nagE fruA fruA mglA mglA wza wza STM3792 STM3792
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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kdgT2Putative permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (317 aa)
STM0577Putative transport protein, PTS system; Similar to E. coli PTS enzyme IIAB, mannose-specific (AAC74887.1); Blastp hit to AAC74887.1 (323 aa), 26% identity in aa 5 - 126. (149 aa)
STM0576Putative transport protein, PTS system; Similar to E. coli PTS enzyme IIAB, mannose-specific (AAC74887.1); Blastp hit to AAC74887.1 (323 aa), 32% identity in aa 163 - 306. (156 aa)
STM0575Putative inner membrane protein; Similar to E. coli PTS enzyme IIC, mannose-specific (AAC74888.1); Blastp hit to AAC74888.1 (266 aa), 34% identity in aa 6 - 240. (247 aa)
STM0574Putative transport protein, PTS system; Similar to E. coli PTS enzyme IID, mannose-specific (AAC74889.1); Blastp hit to AAC74889.1 (286 aa), 37% identity in aa 4 - 284. (284 aa)
STM4538Putative PTS permease; Similar to E. coli PTS enzyme IID, mannose-specific (AAC74889.1); Blastp hit to AAC74889.1 (286 aa), 41% identity in aa 6 - 283. (278 aa)
STM4537Putative PTS permease; Similar to E. coli PTS system N-acetylgalactosamine-specific IIC component 1 (AAC76173.1); Blastp hit to AAC76173.1 (267 aa), 31% identity in aa 6 - 263. (259 aa)
STM4536Putative PTS permease; Similar to E. coli PTS enzyme IIAB, mannose-specific (AAC74887.1); Blastp hit to AAC74887.1 (323 aa), 30% identity in aa 162 - 311. (153 aa)
STM4535Putative PTS permease; Similar to E. coli PTS enzyme IIAB, mannose-specific (AAC74887.1); Blastp hit to AAC74887.1 (323 aa), 22% identity in aa 6 - 127. (140 aa)
STM4534Putative NtrC family transcriptional regulator, ATPase domain protein; Similar to E. coli psp operon transcriptional activator (AAC74385.1); Blastp hit to AAC74385.1 (330 aa), 38% identity in aa 13 - 242. (921 aa)
idnTGntP family L-idonate transport protein; Similar to E. coli L-idonate transporter (AAC77222.1); Blastp hit to AAC77222.1 (439 aa), 94% identity in aa 1 - 439. (439 aa)
STM3782Similar to E. coli PTS system galactitol-specific enzyme IIC (AAC75153.1); Blastp hit to AAC75153.1 (451 aa), 40% identity in aa 5 - 432. (452 aa)
STM3773Putative NtrC family transcriptional regulator; ATPase domain; similar to E. coli psp operon transcriptional activator (AAC74385.1); Blastp hit to AAC74385.1 (330 aa), 33% identity in aa 12 - 239. (932 aa)
STM3772Putative phosphotransferase system enzyme IIA. (141 aa)
STM4448Putative phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type). (637 aa)
kdgT2-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (317 aa)
STM4419Sugar (and other) transporter; Similar to E. coli xylose-proton symport (AAC77001.1); Blastp hit to AAC77001.1 (491 aa), 33% identity in aa 58 - 486, 39% identity in aa 3 - 106; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa)
STM4418Sugar (and other) transporter; Similar to E. coli xylose-proton symport (AAC77001.1); Blastp hit to AAC77001.1 (491 aa), 41% identity in aa 58 - 487, 47% identity in aa 5 - 103; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
ptxAPutative PTS enzyme IIsga subunit; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (154 aa)
sgaBPutative PTS enzyme IIsga subunit; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (101 aa)
sgaTPutative PTS enzyme IIsga subunit; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (476 aa)
lamBPhage lambda receptor protein; Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages; Belongs to the porin LamB (TC 1.B.3) family. (452 aa)
malKMaltose transport protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (369 aa)
pduFPropanediol utilization protein; May facilitate the diffusion of propanediol; Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
manZMannose-specific enzyme IID; Sugar Specific PTS family; similar to E. coli PTS enzyme IID, mannose-specific (AAC74889.1); Blastp hit to AAC74889.1 (286 aa), 92% identity in aa 1 - 285. (286 aa)
manYMannose-specific enzyme IIC; Sugar Specific PTS family; similar to E. coli PTS enzyme IIC, mannose-specific (AAC74888.1); Blastp hit to AAC74888.1 (266 aa), 94% identity in aa 1 - 266. (266 aa)
manXMannose-specific enzyme IIAB; Sugar Specific PTS family; similar to E. coli PTS enzyme IIAB, mannose-specific (AAC74887.1); Blastp hit to AAC74887.1 (323 aa), 95% identity in aa 1 - 323. (322 aa)
STM3783Putative periplasmic protein; Similar to E. coli galactitol-specific enzyme IIB of phosphotransferase system (AAC75154.1); Blastp hit to AAC75154.1 (94 aa), 37% identity in aa 1 - 94. (95 aa)
STM3858Putative phosphotransferase system fructose-specific component IIB; Similar to E. coli PTS system, fructose-specific transport protein (AAC75228.1); Blastp hit to AAC75228.1 (563 aa), 66% identity in aa 104 - 552. (457 aa)
rbsAD-ribose high-affinity transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (501 aa)
rhaTDMT Superfamily L-rhamnose:H+ symporter protein; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system); Belongs to the L-rhamnose transporter (TC 2.A.7.6) family. (344 aa)
glpFSimilar to E. coli facilitated diffusion of glycerol (AAC76909.1); Blastp hit to AAC76909.1 (281 aa), 92% identity in aa 1 - 281; Belongs to the MIP/aquaporin (TC 1.A.8) family. (281 aa)
ptsAGeneral PTS family enzyme I; Similar to E. coli PEP-protein phosphotransferase system enzyme I (AAC76929.1); Blastp hit to AAC76929.1 (711 aa), 90% identity in aa 1 - 711. (833 aa)
frwCSimilar to E. coli PTS system, fructose-like enzyme II component (AAC76931.1); Blastp hit to AAC76931.1 (359 aa), 93% identity in aa 1 - 359. (359 aa)
frwBSimilar to E. coli PTS system fructose-like IIB component 1 (AAC76932.1); Blastp hit to AAC76932.1 (106 aa), 96% identity in aa 1 - 106. (106 aa)
frwDSimilar to E. coli PTS system fructose-like IIB component 2 (AAC76935.1); Blastp hit to AAC76935.1 (113 aa), 83% identity in aa 3 - 113. (117 aa)
malGMaltose transport protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. (296 aa)
malFMaltose transport protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. (514 aa)
malEMaltose transport protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. (399 aa)
STM0571Putative inner membrane protein; Unknown (gi|2896134). (909 aa)
yadISimilar to E. coli putative PTS enzyme II B component (AAC73240.1); Blastp hit to AAC73240.1 (146 aa), 76% identity in aa 1 - 146. (146 aa)
setBProton efflux pump; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose (By similarity); Belongs to the major facilitator superfamily. Set transporter family. (393 aa)
STM2342Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77150.1); Blastp hit to AAC77150.1 (484 aa), 27% identity in aa 30 - 483. (463 aa)
STM2343Putative cytoplasmic protein. (90 aa)
ptsHPhosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (85 aa)
ptsIPEP-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa)
crrGlucose-specific IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. It can also phosphorylate mannose, methyl alpha-glucoside and 2-deoxy-glucose. The non-phosphorylated EIII-Glc is an inhibitor for uptake of certain sugars such as maltose, melibiose, lactose, and glycerol. Phosphorylated EIII-Glc [...] (169 aa)
hcaTSimilar to E. coli MFS (major facilitator superfamily) transporter (AAC75589.1); Blastp hit to AAC75589.1 (379 aa), 88% identity in aa 1 - 376. (379 aa)
STM2570Putative phosphotransferase system IIB components; Similar to E. coli putative PTS enzyme II (AAC75482.1); Blastp hit to AAC75482.1 (474 aa), 38% identity in aa 6 - 467. (453 aa)
STM2750Similar to E. coli PTS system, glucitol/sorbitol-specific IIC component, one of two (AAC75744.1); Blastp hit to AAC75744.1 (187 aa), 40% identity in aa 9 - 162. (173 aa)
STM2751Similar to E. coli PTS system, glucitol/sorbitol-specific enzyme IIA component (AAC75746.1); Blastp hit to AAC75746.1 (123 aa), 41% identity in aa 3 - 107. (124 aa)
STM2752Putative PTS enzyme III glucitol; Similar to E. coli PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components (AAC75745.1); Blastp hit to AAC75745.1 (319 aa), 45% identity in aa 1 - 314. (326 aa)
STM2758Putative phosphotransferase system IIC component; Similar to E. coli PTS system, glucose-specific IIBC component (AAC74185.1); Blastp hit to AAC74185.1 (477 aa), 44% identity in aa 44 - 477, 42% identity in aa 4 - 93. (513 aa)
srlAOne of two IIC components; similar to E. coli PTS system, glucitol/sorbitol-specific IIC component, one of two (AAC75744.1); Blastp hit to AAC75744.1 (187 aa), 96% identity in aa 1 - 187. (187 aa)
srlEOne of two IIC components; similar to E. coli PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components (AAC75745.1); Blastp hit to AAC75745.1 (319 aa), 92% identity in aa 1 - 319. (323 aa)
slrBSimilar to E. coli PTS system, glucitol/sorbitol-specific enzyme IIA component (AAC75746.1); Blastp hit to AAC75746.1 (123 aa), 82% identity in aa 1 - 118. (120 aa)
ptsPGeneral PTS system enzyme I, transcriptional regulator with NPR and NTR proteins; Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I-Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr. (748 aa)
STM3134Putative permease; Similar to E. coli transport of hexuronates (AAC76128.1); Blastp hit to AAC76128.1 (472 aa), 47% identity in aa 43 - 454. (434 aa)
STM3255Putative phosphotransferase system fructose-specific component IIB; Similar to E. coli PTS system, fructose-specific transport protein (AAC75228.1); Blastp hit to AAC75228.1 (563 aa), 42% identity in aa 104 - 562, 32% identity in aa 2 - 41. (475 aa)
STM3256Putative phosphotransferase system mannitol/fructose-specific IIA domain protein; Similar to E. coli PTS system, fructose-specific IIA/fpr component (AAC75230.1); Blastp hit to AAC75230.1 (376 aa), 52% identity in aa 3 - 141, 41% identity in aa 197 - 374. (268 aa)
gatZPutative tagatose 6-phosphate kinase 1; Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol. (423 aa)
STM3259Similar to E. coli galactitol-specific enzyme IIB of phosphotransferase system (AAC75154.1); Blastp hit to AAC75154.1 (94 aa), 77% identity in aa 1 - 94. (94 aa)
STM3260Similar to E. coli PTS system galactitol-specific enzyme IIC (AAC75153.1); Blastp hit to AAC75153.1 (451 aa), 85% identity in aa 1 - 446. (457 aa)
ptsNSugar specific PTS family enzyme IIA; Also regulates N metabolism; similar to E. coli phosphotransferase system enzyme IIA, regulates N metabolism (AAC76236.1); Blastp hit to AAC76236.1 (163 aa), 95% identity in aa 1 - 163. (163 aa)
ptsOPhosphocarrier protein HPr-like NPr; Nitrogen related; exchanges phosphate with Enzyme I; similar to E. coli phosphocarrier protein HPr-like NPr, nitrogen related, exchanges phosphate with Enzyme I, Hpr (AAC76238.1); Blastp hit to AAC76238.1 (90 aa), 96% identity in aa 1 - 90. (90 aa)
mtlASimilar to E. coli PTS system, mannitol-specific enzyme IIABC components (AAC76623.1); Blastp hit to AAC76623.1 (637 aa), 95% identity in aa 1 - 637. (638 aa)
STM3769Putative phosphotransferase system enzyme II; Similar to E. coli PTS enzyme IID, mannose-specific (AAC74889.1); Blastp hit to AAC74889.1 (286 aa), 39% identity in aa 16 - 286. (286 aa)
STM3770Putative phosphotransferase system enzyme IIC; Similar to E. coli PTS system N-acetylgalactosamine-specific IIC component 1 (AAC76173.1); Blastp hit to AAC76173.1 (267 aa), 31% identity in aa 19 - 232. (249 aa)
STM3771Putative phosphotransferase system enzyme IIB; Similar to E. coli PTS enzyme IIAB, mannose-specific (AAC74887.1); Blastp hit to AAC74887.1 (323 aa), 29% identity in aa 164 - 320. (161 aa)
STM1614Similar to E. coli putative PTS system enzyme IIC component (AAC77260.1); Blastp hit to AAC77260.1 (437 aa), 94% identity in aa 1 - 437. (437 aa)
STM1613Putative PTS system, enzymeIIB component; Similar to E. coli galactitol-specific enzyme IIB of phosphotransferase system (AAC75154.1); Blastp hit to AAC75154.1 (94 aa), 34% identity in aa 1 - 92. (93 aa)
fruFPhosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. (376 aa)
ydeAMFS family L-arabinose/isopropyl-beta-D-thiogalactopyranoside export protein; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. (396 aa)
celCSimilar to E. coli PEP-dependent phosphotransferase enzyme III for cellobiose, arbutin, and salicin (AAC74806.1); Blastp hit to AAC74806.1 (116 aa), 87% identity in aa 1 - 115. (115 aa)
celBPTS family sugar specific enzyme II for cellobiose, arbutin, and salicin; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (452 aa)
celASimilar to E. coli PEP-dependent phosphotransferase enzyme IV for cellobiose, arbutin, and salicin (AAC74808.1); Blastp hit to AAC74808.1 (106 aa), 96% identity in aa 1 - 106. (106 aa)
ptsGGlucose-specific IIBC component of the Sugar Specific PTS family; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration. It can also phosphorylate mannose, methyl alpha-glucoside and 2-deoxy-glucose. (477 aa)
STM0885Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77151.1); Blastp hit to AAC77151.1 (101 aa), 25% identity in aa 2 - 97. (106 aa)
STM0884Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77150.1); Blastp hit to AAC77150.1 (484 aa), 38% identity in aa 20 - 441. (447 aa)
nagESimilar to E. coli PTS system, N-acetylglucosamine-specific enzyme IIABC (AAC73773.1); Blastp hit to AAC73773.1 (648 aa), 92% identity in aa 1 - 647. (650 aa)
fruAFructose-specific transport protein; Sugar Specific PTS system; similar to E. coli PTS system, fructose-specific transport protein (AAC75228.1); Blastp hit to AAC75228.1 (563 aa), 92% identity in aa 1 - 563. (562 aa)
mglAGalactose (methyl-galactoside) transport protein; Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable). (506 aa)
wzaPutative polysaccharide export protein; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium. (379 aa)
STM3792Putative L-fucose permease; Similar to E. coli fucose permease (AAC75843.1); Blastp hit to AAC75843.1 (438 aa), 34% identity in aa 17 - 428. (438 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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