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| | secG | Preprotein translocase IISP family protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa) |
| | exbB | Uptake of enterochelin; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity). (244 aa) |
| | exbD | tonB-dependent uptake of B colicins; similar to E. coli uptake of enterochelin; tonB-dependent uptake of B colicins (AAC76041.1); Blastp hit to AAC76041.1 (141 aa), 93% identity in aa 1 - 141. (141 aa) |
| | ppdB | Prepilin peptidase dependent protein B; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein B (AAC75864.1); Blastp hit to AAC75864.1 (187 aa), 67% identity in aa 3 - 187. (187 aa) |
| | sopD | Secreted protein in the Sop family; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to replication in macrophages. Plays a role, cooperatively with SopB, in membrane fission and macropinosome formation during invasion. (317 aa) |
| | invG | Outer membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. (562 aa) |
| | invE | Invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA. Positively regulates the secretion of SPI-1 TTSS effector proteins SipB, SipC and SipD and negatively influences the secretion of [...] (372 aa) |
| | invA | Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (685 aa) |
| | invC | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. (431 aa) |
| | spaO | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (303 aa) |
| | spaP | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (224 aa) |
| | spaQ | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the FliQ/MopD/SpaQ family. (86 aa) |
| | spaR | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (263 aa) |
| | spaS | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the type III secretion exporter family. (356 aa) |
| | sicP | Chaparone related to virulence; Molecular chaperone required for SptP stabilization and secretion. (130 aa) |
| | prgI | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells; Belongs to the MxiH/PrgI/YscF family. (80 aa) |
| | prgJ | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. (101 aa) |
| | prgK | Cell invasion protein; Required for invasion of epithelial cells. Could be involved in protein secretion; Belongs to the YscJ lipoprotein family. (252 aa) |
| | orgA | Putative flagellar biosynthesis/type III secretory pathway protein; Oxygen-regulated protein required for bacterial internalization. (226 aa) |
| | STM2692 | Putative HlyD family secretion protein. (387 aa) |
| | smpA | Small membrane protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (112 aa) |
| | ffh | 4.5S-RNP protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components; Belongs to the [...] (453 aa) |
| | yfiO | Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa) |
| | yfgL | Putative serine/threonine protein kinase; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa) |
| | nlpB | Lipoprotein-34; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (344 aa) |
| | STM2138 | Putative cytoplasmic protein. (138 aa) |
| | fliR | Putative flagellar biosynthetic protein; Role in flagellar biosynthesis; Belongs to the FliR/MopE/SpaR family. (264 aa) |
| | fliQ | Flagellar biosynthesis protein; Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis; Belongs to the FliQ/MopD/SpaQ family. (89 aa) |
| | fliP | Flagellar biosynthesis protein; Plays a role in the flagellum-specific transport system. (245 aa) |
| | fliJ | Flagellar FliJ protein; Flagellar protein that affects chemotactic events. (147 aa) |
| | fliI | Flagellum-specific ATP synthase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage; Belongs to the ATPase alpha/beta chains family. (456 aa) |
| | fliH | Flagellar biosynthesis protein; Needed for flagellar regrowth and assembly. (235 aa) |
| | flhB | Putative part of export apparatus for flagellar proteins; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (383 aa) |
| | flhA | Flagellar biosynthesis protein; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. (692 aa) |
| | lolB | Outer membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (207 aa) |
| | oppA | Oligopeptide transport protein with chaperone properties; This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity; Belongs to the bacterial solute-binding protein 5 family. (582 aa) |
| | oppB | Oligopeptide transport protein; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (306 aa) |
| | oppC | Oligopeptide transport protein; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (302 aa) |
| | oppD | Oligopeptide transport protein; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. (335 aa) |
| | oppF | Oligopeptide transport protein; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. (334 aa) |
| | tonB | TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific en [...] (242 aa) |
| | steC | Putative inner membrane protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is a kinase, which is required for SPI-2 TTSS-dependent F-actin meshwork formation in infected host cells. (457 aa) |
| | sapF | ABC superfamily peptide transport protein; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. Belongs to the ABC transporter superfamily. (268 aa) |
| | sapD | ABC superfamily peptide transport protein; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. Belongs to the ABC transporter superfamily. (330 aa) |
| | sapC | ABC superfamily peptide transport protein; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (296 aa) |
| | sapB | ABC superfamily peptide transport protein; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. (321 aa) |
| | sapA | ABC superfamily peptide transport protein; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. Belongs to the bacterial solute-binding protein 5 family. (549 aa) |
| | ydgR | Putative POT family peptide transport protein; Proton-dependent permease that transports di- and tripeptides. (501 aa) |
| | ssaU | Secretion system apparatus protein; Part of a type III secretion system; Belongs to the type III secretion exporter family. (352 aa) |
| | ssaT | Secretion system apparatus protein; Part of a type III secretion system; Belongs to the FliR/MopE/SpaR family. (259 aa) |
| | ssaS | Secretion system apparatus; Part of a type III secretion system; Belongs to the FliQ/MopD/SpaQ family. (88 aa) |
| | ssaR | Homology with YscR of the secretion system of Yersinia; virulence protein yscr (SW:YSCR_SALTY). (215 aa) |
| | ssaQ | Secretion system apparatus protein; Part of a type III secretion system. (322 aa) |
| | ssaP | Secretion system apparatus protein SSAP. (SW:SSAP_SALTY). (124 aa) |
| | ssaO | Secretion system apparatus protein SSAO. (SW:SSAO_SALTY). (125 aa) |
| | ssaN | Homology with the YscN family of proteins; probable secretion system apparatus ATP synthase SSAN. (SW:SSAN_SALTY); Belongs to the ATPase alpha/beta chains family. (433 aa) |
| | ssaV | Secretion system apparatus protein; Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB toxin. (681 aa) |
| | ssaM | Secretion system apparatus protein SSAM. (SW:SSAM_SALTY). (122 aa) |
| | ssaL | Secretion system apparatus protein SSAL. (SW:SSAL_SALTY). (338 aa) |
| | ssaK | Secretion system apparatus protein SSAK. (SW:SSAK_SALTY). (224 aa) |
| | ssaJ | Secretion system apparatus protein; Component of Salmonella pathogenicity island 2 (SPI-2) type III secretion system, required for secretion of some type III-secreted effectors including the SpvB toxin. (249 aa) |
| | ssaI | Secretion system apparatus; SsaI (gi|3776129). (82 aa) |
| | ssaG | Secretion system apparatus; SsaH (gi|2460267). (71 aa) |
| | sseD | Secretion system effector; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells. (195 aa) |
| | sseC | Secretion system effector; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells. (484 aa) |
| | sscA | Secretion system chaparone; Putative secretion chaperone (gi|3377863). (157 aa) |
| | sseB | Secretion system effector; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells. SseB is required for correct localization of SseC and SseD on the bacterial cell surface. (196 aa) |
| | ssaC | Secretion system apparatus protein; SpiA (gi|1498307). (497 aa) |
| | ssaB | Secretion system apparatus protein; Virulence protein that plays a central role in mammalian macrophage infection, by inhibiting phagosome-lysosome fusion and cellular trafficking. May act by disrupting the function of the mammalian HOOK3 protein, a protein involved in the cellular traffic. (133 aa) |
| | ycfW | Integral membrane protein ABC transporter; Similar to E. coli putative kinase (AAC74202.1); Blastp hit to AAC74202.1 (414 aa), 92% identity in aa 1 - 414. (414 aa) |
| | ycfV | ATP-binding protein ABC transporter; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (233 aa) |
| | ycfU | Integral membrane protein ABC transporter; Similar to E. coli orf, hypothetical protein (AAC74200.1); Blastp hit to AAC74200.1 (399 aa), 93% identity in aa 1 - 399. (436 aa) |
| | pipB | Pathogenicity island encoded protein: SPI5; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Does not appear to be required for the formation or the maintenance of either Salmonella- containing vacuole (SCV) or the Salmonella-induced filaments (Sifs). Not required for intracellular replication in phagocytic cells. (291 aa) |
| | sopD2 | Homologous to secreted protein sopD; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to the formation of Salmonella-induced filaments (Sifs) in infected epithelial cells and to replication in macrophages. (319 aa) |
| | lolA | Periplasmic protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (204 aa) |
| | slrP | Leucine-rich repeat protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death. (765 aa) |
| | tolB | Tol protein required for outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (430 aa) |
| | tolA | Similar to E. coli membrane spanning protein, required for outer membrane integrity (AAC73833.1); Blastp hit to AAC73833.1 (421 aa), 70% identity in aa 1 - 420. (407 aa) |
| | tolR | Tol protein, role in outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa) |
| | tolQ | Tol protein, membrane-spanning inner membrane protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (230 aa) |
| | ybgH | Putative POT family transport protein; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. (493 aa) |
| | ybeC | Putative Sec-independent protein secretion pathway component; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (67 aa) |
| | ybaV | Putative DNA uptake protein and related DNA-binding proteins; Similar to E. coli orf, hypothetical protein (AAC73545.1); Blastp hit to AAC73545.1 (123 aa), 83% identity in aa 1 - 123. (124 aa) |
| | sspH2 | Leucine-rich repeat protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. (788 aa) |
| | ytfN | Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC77178.1); Blastp hit to AAC77178.1 (1259 aa), 86% identity in aa 1 - 1259. (1259 aa) |
| | ytfM | Putative outer membrane protein; Similar to E. coli orf, hypothetical protein (AAC77177.1); Blastp hit to AAC77177.1 (577 aa), 90% identity in aa 3 - 577. (577 aa) |
| | STM4260 | Membrane permease; Predicted cation efflux pump; HLYD secretion protein (gi|7467244). (425 aa) |
| | STM4258 | Putative methyl-accepting chemotaxis protein; Hypothetical protein spi4_A (gi|7467268). (462 aa) |
| | secE | Preprotein translocase IISP family, membrane subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (127 aa) |
| | tatC | Component of sec-independent protein export; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (259 aa) |
| | tatB | Component of Sec-independent protein secretion pathway; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (182 aa) |
| | tatA | Component of Sec-independent protein secretion pathway; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (84 aa) |
| | yidC | Putative preprotein translocase subunit YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (548 aa) |
| | secB | Molecular chaperone in protein export; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA; Belongs to the SecB family. (155 aa) |
| | sadA | Putative inner membrane protein; Involved in cell aggregation, biofilm formation, and adhesion to human intestinal epithelial cells; Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family. (1461 aa) |
| | yhiP | Putative POT family peptide transport protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa) |
| | ftsY | GTPase domain of cell division membrane protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (491 aa) |
| | hofQ | Putative transport protein; Possibly in biosynthesis of type IV pilin; similar to E. coli putative transport portein (AAC76416.1); Blastp hit to AAC76416.1 (412 aa), 86% identity in aa 1 - 412. (412 aa) |
| | secY | Preprotein translocase of IISP family; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa) |
| | tig | Peptidyl-prolyl cis/trans isomerase; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (432 aa) |
| | secF | Preprotein translocase, IISP family, membrane subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (323 aa) |
| | secD | Preprotein translocase, IISP family, part of the channel; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (615 aa) |
| | yajC | Preprotein translocase IISP family, membrane subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa) |
| | hlpA | Histone-like protein, located in outer membrane; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. (161 aa) |
| | yaeT | Putative outer membrane antigen; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (804 aa) |
| | hofC | Similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73217.1); Blastp hit to AAC73217.1 (400 aa), 67% identity in aa 1 - 400. (400 aa) |
| | secA | Preprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (901 aa) |
