STRINGSTRING
iolG iolG STM4431 STM4431 iolE iolE STM4420 STM4420 cysQ cysQ glpK glpK tpiA tpiA STM3781 STM3781 mtlD mtlD STM3261 STM3261 gatZ gatZ gatY gatY suhB suhB eutS eutS eutP eutP eutQ eutQ eutT eutT eutD eutD eutM eutM eutN eutN eutE eutE eutJ eutJ eutG eutG eutH eutH eutA eutA eutB eutB eutC eutC eutL eutL eutK eutK eutR eutR glpB glpB glpA glpA pduX pduX pduW pduW pduV pduV pduU pduU pduT pduT pduS pduS pduQ pduQ pduP pduP pduO pduO pduN pduN pduM pduM pduL pduL pduK pduK pduJ pduJ pduH pduH pduG pduG pduE pduE pduD pduD pduC pduC pudB pudB pduA pduA pocR pocR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
iolGPutative dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (336 aa)
STM4431Putative thiamine pyrophosphate-requiring enzyme; Similar to E. coli acetolactate synthase I, valine-sensitive, large subunit (AAC76694.1); Blastp hit to AAC76694.1 (562 aa), 27% identity in aa 26 - 326, 34% identity in aa 12 - 126; Belongs to the TPP enzyme family. (646 aa)
iolEPutative endonuclease; Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). Belongs to the IolE/MocC family. (306 aa)
STM4420Putative inner membrane protein. (269 aa)
cysQCysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. (246 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
STM3781Putative sugar (pentulose and hexulose) kinase; Similar to E. coli L-fuculokinase (AAC75845.1); Blastp hit to AAC75845.1 (482 aa), 24% identity in aa 17 - 444. (494 aa)
mtlDSimilar to E. coli mannitol-1-phosphate dehydrogenase (AAC76624.1); Blastp hit to AAC76624.1 (382 aa), 93% identity in aa 1 - 380. (382 aa)
STM3261Similar to E. coli galactitol-1-phosphate dehydrogenase (AAC75152.1); Blastp hit to AAC75152.1 (346 aa), 68% identity in aa 1 - 344. (347 aa)
gatZPutative tagatose 6-phosphate kinase 1; Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol. (423 aa)
gatYPutative fructose/tagatose biphosphate aldolase; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. (284 aa)
suhBInositol monophosphatase; Similar to E. coli enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action (AAC75586.1); Blastp hit to AAC75586.1 (267 aa), 97% identity in aa 1 - 267; Belongs to the inositol monophosphatase superfamily. (267 aa)
eutSPutative ethanol utilization carboxysome structural protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the EutS/PduU family. (111 aa)
eutPEthanolamine utilization protein EUTP. (SW:EUTP_SALTY). (159 aa)
eutQEthanolamine utilization protein EUTQ. (SW:EUTQ_SALTY). (229 aa)
eutTPutative ethanolamine utilization cobalamin adenosyltransferase; Converts CNB12 to ADOB12. (267 aa)
eutDEthanolamine utilization protein EUTD. (SW:EUTD_SALTY). (338 aa)
eutMPutative detox protein in ethanolamine utilization; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the bacterial microcompartments protein family. (96 aa)
eutNPutative detox protein in ethanolamine utilization; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; To cyanobacterial carbon dioxide concentrating mechanism protein CcmL. (99 aa)
eutEPutative aldehyde oxidoreductase in ethanolamine utilization; May act as an acetaldehyde dehydrogenase that converts acetaldehyde into acetyl-CoA. (467 aa)
eutJPutative heatshock protein (Hsp70); Ethanolamine utilization protein EUTJ. (SW:EUTJ_SALTY). (279 aa)
eutGPutative transport protein in ethanolamine utilization; May act on the acetaldehyde produced from the degradation of ethanolamine; Belongs to the iron-containing alcohol dehydrogenase family. (395 aa)
eutHPutative transport protein; Possibly involved in the transport of ethanolamine from the periplasm to the cytoplasm. (408 aa)
eutACPPZ-55 prophage protein; May protect the EutBC lyase from inhibition. (467 aa)
eutBEthanolamine ammonia-lyase, heavy chain; Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. (453 aa)
eutCEthanolamine ammonia-lyase, light chain; Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. (298 aa)
eutLPutative carboxysome structural protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the EutL/PduB family. (219 aa)
eutKPutative carboxysome structural protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the bacterial microcompartments protein family. (164 aa)
eutRPutative regulator ethanolamine operon; Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors. (350 aa)
glpBSn-glycerol-3-phosphate dehydrogenase (anaerobic), membrane anchor subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor; Belongs to the anaerobic G-3-P dehydrogenase subunit B family. (419 aa)
glpASimilar to E. coli sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit (AAC75301.1); Blastp hit to AAC75301.1 (542 aa), 92% identity in aa 1 - 542; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa)
pduXPropanediol utilization protein; L-threonine kinase that catalyzes the conversion of L- threonine to L-threonine-O-3-phosphate. Involved in the de novo synthesis of adenosylcobalamin (coenzyme B12) and the assimilation of cobyric acid. Uses ATP; the activity with CTP, GTP or UTP is 6, 11, and 3% of the activity with ATP, respectively. (300 aa)
pduWProbable propionate kinase. (SW:PDUW_SALTY); Belongs to the acetokinase family. PduW subfamily. (404 aa)
pduVPropanediol utilization protein PDUV. (SW:PDUV_SALTY). (150 aa)
pduUPolyhedral bodies; propanediol utilization protein PDUU. (SW:PDUU_SALTY). (116 aa)
pduTPropanediol utilization protein; Polyhedral bodies; similar to E. coli detox protein (AAC75510.1); Blastp hit to AAC75510.1 (111 aa), 41% identity in aa 16 - 93, 31% identity in aa 16 - 90. (184 aa)
pduSPropanediol utilization protein; Polyhedral bodies; similar to E. coli putative membrane protein (AAC74701.1); Blastp hit to AAC74701.1 (740 aa), 33% identity in aa 131 - 448, 37% identity in aa 33 - 93. (451 aa)
pduQPropanediol utilization propanol dehydrogenase; Similar to E. coli CoA-linked acetaldehyde dehydrogenase and iron-dependent alcohol dehydrogenase; pyruvate-formate-lyase deactivase (AAC74323.1); Blastp hit to AAC74323.1 (891 aa), 40% identity in aa 574 - 860, 35% identity in aa 456 - 556. (370 aa)
pduPPropanediol utilization CoA-dependent propionaldehyde dehydrogenase; Similar to E. coli ethanolamine utilization; similar to acetaldehyde dehydrogenase (AAC75508.1); Blastp hit to AAC75508.1 (467 aa), 45% identity in aa 1 - 466. (464 aa)
pduOPropanediol utilization B12 related protein; Belongs to the Cob(I)alamin adenosyltransferase family. (336 aa)
pduNPropanediol utilization protein; Polyhedral bodies; similar to E. coli detox protein (AAC75509.1); Blastp hit to AAC75509.1 (95 aa), 43% identity in aa 1 - 83. (91 aa)
pduMPropanediol utilization protein. (163 aa)
pduLPropanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. Is also able to catalyze the reverse reaction. To a lesser extent, also displays phosphate acetyltransferase activity. Belongs to the PduL family. (210 aa)
pduKPropanediol utilization protein; Polyhedral bodies; similar to E. coli detox protein (AAC75510.1); Blastp hit to AAC75510.1 (111 aa), 35% identity in aa 9 - 92. (160 aa)
pduJPropanediol utilization protein; Polyhedral bodies; similar to E. coli detox protein (AAC75510.1); Blastp hit to AAC75510.1 (111 aa), 64% identity in aa 17 - 101. (91 aa)
pduHPropanediol utilization diol dehydratase reactivation protein. (116 aa)
pduGPropanediol utilization diol dehydratase reactivation protein. (610 aa)
pduEPropanediol utilization dehydratase, small subunit; Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol to propionaldehyde. Is required for S.typhimurium growth on 1,2-propanediol as the sole carbon and energy source; Belongs to the diol/glycerol dehydratase small subunit family. (173 aa)
pduDPropanediol utilization dehydratase, medium subunit; Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol to propionaldehyde. Is required for S.typhimurium growth on 1,2-propanediol as the sole carbon and energy source. (224 aa)
pduCPropanediol utilization dehydratase, large subunit; Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol to propionaldehyde. Is required for S.typhimurium growth on 1,2-propanediol as the sole carbon and energy source. (554 aa)
pudBPolyhedral bodies; propanediol utilization protein PDUB. (SW:PDUB_SALTY). (233 aa)
pduAPolyhedral bodies; propanediol utilization protein PDUA. (SW:PDUA_SALTY). (94 aa)
pocRPropanediol utilization protein; Positive regulatory protein of pdu and cob operons. (303 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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