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| | basR | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. (222 aa) |
| | cheB | Methyl esterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid (By similarity). Belongs to the CheB family. (349 aa) |
| | cheY | Chemotaxis regulator protein; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation. Shows autophosphatase activity which is enhanced by CheZ. (129 aa) |
| | ruvC | Holliday junction nuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (173 aa) |
| | ruvA | Holliday junction helicase subunit A; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa) |
| | ruvB | Holliday junction helicase, subunit B; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa) |
| | exoX | DNA exonuclease X; Degrades ss and ds DNA with 3'-5' polarity; similar to E. coli orf, hypothetical protein (AAC74914.1); Blastp hit to AAC74914.1 (220 aa), 90% identity in aa 1 - 219. (232 aa) |
| | prc | Carboxy-terminal protease for penicillin-binding protein 3; Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses (By similarity). (682 aa) |
| | yoaA | Putative DNA helicase; Similar to E. coli putative enzyme (AAC74878.1); Blastp hit to AAC74878.1 (636 aa), 95% identity in aa 1 - 635. (636 aa) |
| | treA | Trehalase, periplasmic; Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system; Belongs to the glycosyl hydrolase 37 family. (570 aa) |
| | narL | Response regulator in two-component regulatory system with NarX (or NarQ); Regulates anaerobic respiration and fermentation (LuxR/UhpA family); similar to E. coli pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes (AAC74305.1); Blastp hit to AAC74305.1 (216 aa), 96% identity in aa 1 - 216. (216 aa) |
| | narX | Sensory histidine kinase in two component regulatory system with NarL; Senses nitrate/nitrite; regulates anaerobic respiration and fermentation; similar to E. coli nitrate/nitrate sensor, histidine protein kinase acts on NarL regulator (AAC74306.1); Blastp hit to AAC74306.1 (598 aa), 86% identity in aa 1 - 598. (598 aa) |
| | hnr | Response regulator in protein turnover; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. (337 aa) |
| | tpx | Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (168 aa) |
| | STM1667 | Similar to E. coli thiol peroxidase (AAC74406.1); Blastp hit to AAC74406.1 (168 aa), 30% identity in aa 45 - 159. (185 aa) |
| | ogt | O-6-alkylguanine-DNA; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (171 aa) |
| | STM1657 | Similar to E. coli methyl-accepting chemotaxis protein I, serine sensor receptor (AAC77311.1); Blastp hit to AAC77311.1 (551 aa), 39% identity in aa 195 - 519. (384 aa) |
| | STM1627 | Similar to E. coli alcohol dehydrogenase class III; formaldehyde dehydrogenase, glutathione-dependent (AAC73459.1); Blastp hit to AAC73459.1 (369 aa), 80% identity in aa 1 - 369; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa) |
| | trg | Methyl-accepting chemotaxis protein III; Ribose and galactose sensor receptor; similar to E. coli methyl-accepting chemotaxis protein III, ribose sensor receptor (AAC74503.1); Blastp hit to AAC74503.1 (546 aa), 79% identity in aa 6 - 526. (541 aa) |
| | osmC | Putative resistance protein; Osmotically inducible; similar to E. coli osmotically inducible protein (AAC74555.1); Blastp hit to AAC74555.1 (143 aa), 92% identity in aa 1 - 143. (143 aa) |
| | hdeB | Putative periplasmic transport protein; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. Belongs to the HdeB family. (109 aa) |
| | rstA | Similar to E. coli response transcriptional regulatory protein (RstB sensor) (AAC74680.1); Blastp hit to AAC74680.1 (242 aa), 84% identity in aa 4 - 242. (243 aa) |
| | rstB | Sensory histidine kinase in two-component regulatory system with RstA; Similar to E. coli sensor histidine protein kinase (RstA regulator) (AAC74681.1); Blastp hit to AAC74681.1 (433 aa), 82% identity in aa 1 - 433. (433 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa) |
| | sodC-2 | Copper/zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (173 aa) |
| | rnt | RNase T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. (215 aa) |
| | sodB | Iron superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (193 aa) |
| | ssrA | Secretion system regulator: Sensor component; SpiR (gi|1498305). (920 aa) |
| | ssrB | Secretion system regulator: transcriptonal activator; Homologous with degU/uvrY/bvgA; SsrB (gi|2765824). (212 aa) |
| | ttrR | Tetrathionate reductase complex: response regulator; Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase. Positively regulates transcription of the ttrBCA operon. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. (206 aa) |
| | ttrS | Tetrathionate reductase complex: sensory transduction histidine kinase; Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase. Probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue in response to tetrathionate, and transfers its phosphate group to TtrR. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. (592 aa) |
| | btuE | Vitamin B12 transport protein; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. (183 aa) |
| | katE | Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (750 aa) |
| | cho | Putative nuclease subunit of the excinuclease complex; Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity). (302 aa) |
| | xthA | Exonuclease III; Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'- 5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities (By similarity). (268 aa) |
| | STM1301 | Putative mutator MutT protein; Similar to E. coli orf, hypothetical protein (AAC74829.1); Blastp hit to AAC74829.1 (135 aa), 77% identity in aa 1 - 135; Belongs to the Nudix hydrolase family. (138 aa) |
| | STM1267 | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74250.1); Blastp hit to AAC74250.1 (88 aa), 41% identity in aa 23 - 88. (82 aa) |
| | phoP | Response regulator in two-component regulatory system with PhoQ; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repressio [...] (224 aa) |
| | phoQ | Sensory kinase protein in two-component regulatory system with PhoP; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane- associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of [...] (487 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1148 aa) |
| | grxB | Glutaredoxin 2; Similar to E. coli glutaredoxin 2 (AAC74148.1); Blastp hit to AAC74148.1 (215 aa), 85% identity in aa 1 - 215. (215 aa) |
| | dinI | DNA damage-inducible protein I; Inhibits UmuD processing; similar to E. coli damage-inducible protein I (AAC74145.1); Blastp hit to AAC74145.1 (81 aa), 85% identity in aa 1 - 81. (81 aa) |
| | putP | SSS family major sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (502 aa) |
| | putA | Plasma membrane proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1320 aa) |
| | iraM | Putative cytoplasmic protein; Involved in the stabilization of the sigma stress factor RpoS; Belongs to the IraM/RssC family. (120 aa) |
| | hpaI | 4-hydroxyphenylacetate catabolism protein; Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde. (263 aa) |
| | hpaB | 4-hydroxyphenylacetate catabolism protein. (520 aa) |
| | copR | Copper resistance transcriptional regulatory protein; Pathogenicity island encoded protein: SPI5; similar to E. coli putative 2-component transcriptional regulator (AAC75035.1); Blastp hit to AAC75035.1 (239 aa), 74% identity in aa 6 - 236. (248 aa) |
| | copS | Copper resistance; Member of a two-component regulatory system. (454 aa) |
| | helD | DNA helicase IV; Similar to E. coli DNA helicase IV (AAC74048.1); Blastp hit to AAC74048.1 (684 aa), 83% identity in aa 1 - 684. (684 aa) |
| | sulA | Suppressor of lon; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (169 aa) |
| | uup | Contains duplicated ATPase domain; similar to E. coli putative ATP-binding component of a transport system (AAC74035.1); Blastp hit to AAC74035.1 (635 aa), 94% identity in aa 1 - 634. (635 aa) |
| | STM1053 | Gifsy-2 prophage protein; Similar to E. coli orf, hypothetical protein (AAC74998.1); Blastp hit to AAC74998.1 (217 aa), 85% identity in aa 1 - 178; Belongs to the SOS response-associated peptidase family. (208 aa) |
| | sodC | Gifsy-2 prophage superoxide dismutase precursor (Cu-Zn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (177 aa) |
| | STM1019 | Gifsy-2 prophage protein; Hypothetical protein 13 (gi|7467262). (77 aa) |
| | ycaI | Putative recombination protein; Similar to E. coli orf, hypothetical protein (AAC73999.1); Blastp hit to AAC73999.1 (780 aa), 70% identity in aa 27 - 780. (754 aa) |
| | trxB | Similar to E. coli thioredoxin reductase (AAC73974.1); Blastp hit to AAC73974.1 (321 aa), 96% identity in aa 1 - 320. (322 aa) |
| | clpA | Similar to E. coli ATP-binding component of serine protease (AAC73969.1); Blastp hit to AAC73969.1 (758 aa), 97% identity in aa 1 - 758; Belongs to the ClpA/ClpB family. (758 aa) |
| | ybjX | Homolog of virK; Similar to E. coli putative enzyme (AAC73964.1); Blastp hit to AAC73964.1 (330 aa), 57% identity in aa 15 - 329. (322 aa) |
| | ybjD | Homology with RecF protein; Similar to E. coli orf, hypothetical protein (AAC73963.1); Blastp hit to AAC73963.1 (552 aa), 89% identity in aa 1 - 552. (552 aa) |
| | hcp | Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (550 aa) |
| | STM0924 | Putative Fels-1 prophage Cu/Zn superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (174 aa) |
| | rimK | Ribosomal protein S6 modification protein; Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH. Belongs to the RimK family. (300 aa) |
| | grxA | Redox coenzyme for glutathione-dependent ribonucleotide reductase glutaredoxin1; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity); Belongs to the glutaredoxin family. (87 aa) |
| | ybiO | Similar to E. coli putative transport protein (AAC73895.1); Blastp hit to AAC73895.1 (786 aa), 85% identity in aa 46 - 786. (740 aa) |
| | dinG | LexA regulated (SOS) repair enzyme; DNA-dependent ATPase and 5'-3' DNA helicase. (714 aa) |
| | uvrB | UvrB with UvrAC is a DNA excision repair enzyme; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA [...] (673 aa) |
| | nei | Endonuclease VIII; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (263 aa) |
| | ybgI | Putative cytoplasmic protein; Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides. Belongs to the GTP cyclohydrolase I type 2/NIF3 family. (247 aa) |
| | phrB | Deoxyribodipyrimidine photolyase (photoreactivation); Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation; Belongs to the DNA photolyase class-1 family. (473 aa) |
| | kdpD | Sensory kinase in two-component regulatory system wtih KdpE; Regulates kdp operon (high-affinity potassium transport system); similar to E. coli sensor for high-affinity potassium transport system (AAC73789.1); Blastp hit to AAC73789.1 (894 aa), 89% identity in aa 1 - 894. (894 aa) |
| | kdpE | Response regulator in two-component regulatory system with KdpD; Regulates kdp operon encoding a high-affinity K translocating ATPase (OmpR family); similar to E. coli regulator of kdp operon (transcriptional effector) (AAC73788.1); Blastp hit to AAC73788.1 (225 aa), 91% identity in aa 1 - 224. (225 aa) |
| | STM0652 | Putative sigma-54 dependent transcriptional regulator; Similar to E. coli response regulator of ato, ornithine decarboxylase antizyme (sensor ATOS) (AAC75280.1); Blastp hit to AAC75280.1 (461 aa), 37% identity in aa 67 - 453. (642 aa) |
| | dpiA | Response regulator in two-component regulatory system with DpiB; Transcriptional regulation of cit operon (citrate fermentation) genes and of plasmid inheritance genes (OmpR family); similar to E. coli sequence similarity to Shigella regulator (AAC73721.1); Blastp hit to AAC73721.1 (226 aa), 84% identity in aa 1 - 226. (226 aa) |
| | dpiB | Sensory histidine kinase in two-component regulatory system with DpiA; Regulation of cit operon and plasmid inheritance genes; similar to E. coli putative sensor-type protein (AAC73720.1); Blastp hit to AAC73720.1 (552 aa), 86% identity in aa 2 - 552. (553 aa) |
| | ahpF | Alkyl hydroperoxide reductase, F52a subunit; Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (521 aa) |
| | ahpC | Alkyl hydroperoxide reductase, C22 subunit; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa) |
| | cstA | Similar to E. coli carbon starvation protein (AAC73699.1); Blastp hit to AAC73699.1 (701 aa), 97% identity in aa 1 - 701. (701 aa) |
| | ybdG | Similar to E. coli putative transport (AAC73678.1); Blastp hit to AAC73678.1 (415 aa), 88% identity in aa 1 - 414. (415 aa) |
| | STM0564 | Similar to E. coli putative oxidoreductase (AAC73407.1); Blastp hit to AAC73407.1 (450 aa), 74% identity in aa 10 - 450. (441 aa) |
| | STM0561 | Sensor protein; Similar to E. coli putative 2-component sensor protein (AAC73671.1); Blastp hit to AAC73671.1 (480 aa), 74% identity in aa 375 - 479. (109 aa) |
| | fimZ | Fimbrial protein Z; Putative transcriptional regulator (LuxR/UhpA family); fimbriae Z protein. (SW:FIMZ_SALTY). (210 aa) |
| | htpG | Chaperone Hsp90, heat shock protein C 62.5; Molecular chaperone. Has ATPase activity. (632 aa) |
| | recR | Putative recombination protein, gap repair; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa) |
| | ybaZ | Putative methyltransferase; Similar to E. coli orf, hypothetical protein (AAC73557.1); Blastp hit to AAC73557.1 (129 aa), 82% identity in aa 1 - 129. (129 aa) |
| | lon | DNA-binding protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (784 aa) |
| | thiJ | 4-methyl-5(beta-hydroxyethyl)-thiazole synthesis; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, g [...] (196 aa) |
| | STM0402 | Similar to E. coli alkyl hydroperoxide reductase, C22 subunit; detoxification of hydroperoxides (AAC73706.1); Blastp hit to AAC73706.1 (187 aa), 36% identity in aa 1 - 186. (200 aa) |
| | phoR | Sensory kinase in two-component regulatory system with PhoB, regulates pho regulon; Similar to E. coli positive and negative sensor protein for pho regulon (AAC73503.1); Blastp hit to AAC73503.1 (431 aa), 90% identity in aa 1 - 431. (431 aa) |
| | phoB | Regulates pho regulon (OmpR family); similar to E. coli positive response regulator for pho regulon, sensor is PhoR (or CreC) (AAC73502.1); Blastp hit to AAC73502.1 (229 aa), 95% identity in aa 1 - 229. (229 aa) |
| | sbcD | ATP-dependent dsDNA exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (400 aa) |
| | yaiB | Putative cytoplasmic protein; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate and magnesium starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway. Belongs to the IraP family. (88 aa) |
| | prpR | Regulator for prp operon (EBP family); Involved in the transcriptional regulation of the propionate catabolism operon. (541 aa) |
| | STM0344 | Putative response regulator. (247 aa) |
| | dinP | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contains the editing function and is a proofreading 3'- 5' exonuclease (By similarity). (243 aa) |
| | rcsF | Regulator in colanic acid synthesis; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (134 aa) |
| | rnhB | RNAse HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (198 aa) |
| | mutT | Prefers dGTP; similar to E. coli 7,8-dihydro-8-oxoguanine-triphosphatase, prefers dGTP, causes AT-GC transversions (AAC73210.1); Blastp hit to AAC73210.1 (129 aa), 80% identity in aa 1 - 128; Belongs to the Nudix hydrolase family. (131 aa) |
| | polB | DNA polymerase II; 3'->5' exonuclease; similar to E. coli DNA polymerase II (AAC73171.1); Blastp hit to AAC73171.1 (783 aa), 89% identity in aa 1 - 783. (783 aa) |
| | apaG | Putative cytoplasmic protein; Not known; mutations in apaG/corD give a phenotype of low- level Co(2+) resistance. They also decrease Mg(2+) efflux but not influx via the CorA Mg(2+) transport system. (125 aa) |
| | STM0053 | Putative transcription regulator; Histidine kinase for citrate; similar to E. coli putative sensor-type protein (AAC73720.1); Blastp hit to AAC73720.1 (552 aa), 42% identity in aa 12 - 538. (539 aa) |
| | STM0052 | Putative transcription regulator sensor for citrate; Similar to E. coli sequence similarity to Shigella regulator (AAC73721.1); Blastp hit to AAC73721.1 (226 aa), 47% identity in aa 5 - 223. (228 aa) |
| | STM0031 | Putative transcriptional regulator MarT (gi|4324612). (146 aa) |
| | STM0029 | Putative transcriptional regulator MarT (gi|4324612). (149 aa) |
| | arcA | Response regulator (OmpR family) in two-component regulatory system with ArcB (or CpxA); Regulates genes in aerobic pathways; similar to E. coli negative response regulator of genes in aerobic pathways, (sensors, ArcB and CpxA) (AAC77354.1); Blastp hit to AAC77354.1 (238 aa), 99% identity in aa 1 - 238. (238 aa) |
| | creC | Sensory kinase (alternative) in two-component regulatory system with CreB (or alternatively PhoB); Senses catabolite repression; similar to E. coli catabolite repression sensor kinase for PhoB; alternative sensor for pho regulon (AAC77352.1); Blastp hit to AAC77352.1 (474 aa), 80% identity in aa 1 - 474. (474 aa) |
| | creB | Response regulator in two-component regulatory system with CreC; OmpR family; similar to E. coli catabolic regulation response regulator (AAC77351.1); Blastp hit to AAC77351.1 (229 aa), 83% identity in aa 1 - 229. (229 aa) |
| | radA | Putative ATP-dependent protease; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. Belongs to the RecA family. RadA subfamily. (460 aa) |
| | tsr | Serine sensor receptor; similar to E. coli methyl-accepting chemotaxis protein I, serine sensor receptor (AAC77311.1); Blastp hit to AAC77311.1 (551 aa), 86% identity in aa 1 - 551. (553 aa) |
| | yjiY | Similar to E. coli putative carbon starvation protein (AAC77310.1); Blastp hit to AAC77310.1 (721 aa), 96% identity in aa 6 - 721. (716 aa) |
| | msrA | Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (212 aa) |
| | mutL | Enzyme in methyl-directed mismatch repair; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (618 aa) |
| | dcuS | Sensory histidine kinase in two-component retgulatory system with DcuR; Senses fumarate/C4-dicarboxylate; similar to E. coli putative 2-component sensor protein (AAC77086.1); Blastp hit to AAC77086.1 (543 aa), 81% identity in aa 1 - 542. (543 aa) |
| | dcuR | Response regulator in two-component regulatory system with DcuS; Regulates anaerobic fumarate respiration; similar to E. coli putative 2-component transcriptional regulator (AAC77085.1); Blastp hit to AAC77085.1 (239 aa), 88% identity in aa 1 - 239. (239 aa) |
| | basS | Sensory kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. (356 aa) |
| | ssb | ssDNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (176 aa) |
| | uvrA | DNA excision repair enzyme; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate; Belongs to the ABC transporter superfamily. UvrA family. (941 aa) |
| | lexA | SOS response regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa) |
| | yjbA | Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77000.1); Blastp hit to AAC77000.1 (136 aa), 87% identity in aa 1 - 136; Belongs to the PsiE family. (136 aa) |
| | hydG | Response regulator in two-component reguatory system with HydH; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity). (441 aa) |
| | hydH | Sensory kinase in two component regulatory system with HydG; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium (By similarity). (465 aa) |
| | nfi | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (223 aa) |
| | katG | Catalase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (726 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa) |
| | cpxR | Response reguator in two-component regulatory system with CpxA; Regulates expression of protein folding and degrading factors (OmpR family); similar to E. coli transcriptional regulator in 2-component system (AAC76894.1); Blastp hit to AAC76894.1 (232 aa), 97% identity in aa 1 - 232. (232 aa) |
| | cpxA | Sensory kinase in two-component regulatory system with CpxR; Senses misfolded proteins in bacterial envelope; similar to E. coli probable sensor protein (histidine protein kinase), acting on arcA (AAC76893.1); Blastp hit to AAC76893.1 (457 aa), 96% identity in aa 1 - 457. (457 aa) |
| | sodA | Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (206 aa) |
| | STM4014 | Putative periplasmic protein. (341 aa) |
| | glnL | Sensory histidine kinase/phosphatase NtrB; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC. (349 aa) |
| | glnG | EBP family response regulator in two-component regulatory system with GlnL; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (469 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template. (928 aa) |
| | fadA | 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity). (387 aa) |
| | recQ | ATP-dependent DNA helicase; Involved in the RecF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase; Belongs to the helicase family. RecQ subfamily. (615 aa) |
| | uvrD | DNA-dependent ATPase I and helicase II; Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; Belongs to the helicase family. UvrD subfamily. (720 aa) |
| | rep | Rep helicase; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (674 aa) |
| | recF | Gap repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). (357 aa) |
| | torS | Histidine kinase; Regulates tor operon; similar to E. coli sensor protein torS (regulator TorR) (AAC74078.1); Blastp hit to AAC74078.1 (904 aa), 62% identity in aa 1 - 896. (911 aa) |
| | torR | Two-component system, OmpR family, torCAD operon response regulator TorR; Regulates tor operon (TorR family); similar to E. coli response transcriptional regulator for torA (sensor TorS) (AAC74080.1); Blastp hit to AAC74080.1 (230 aa), 81% identity in aa 1 - 229. (230 aa) |
| | STM3820 | Similar to E. coli putative cytochrome C peroxidase (AAC76543.1); Blastp hit to AAC76543.1 (465 aa), 82% identity in aa 2 - 463. (466 aa) |
| | ysdB | Conserved protein in the LexA regulon. (29 aa) |
| | uhpA | Response regulator (repressor) in two-component regulatory system wtih UhpB; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region. (196 aa) |
| | uhpB | Sensory histidine kinase in two-component regulatory sytem with UhpA; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA. (500 aa) |
| | marT | Pathogenicity island encoded protein: SPI3; putative transcriptional regulator MarT (gi|4324612). (285 aa) |
| | sugR | ATP binding protein; Putative cytoplasmic protein; Pathogenicity island encoded protein: SPI3; putative ATP binding protein SugR (gi|4324607). (396 aa) |
| | recG | DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (693 aa) |
| | yicF | Putative DNA ligase; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. (561 aa) |
| | mutM | Formamidopyrimidine DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). (269 aa) |
| | grxC | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (83 aa) |
| | sgbU | Similar to E. coli probable 3-hexulose-6-phosphate isomerase (AAC76606.1); Blastp hit to AAC76606.1 (297 aa), 91% identity in aa 12 - 297. (286 aa) |
| | yiaB | Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC76587.1); Blastp hit to AAC76587.1 (117 aa), 33% identity in aa 15 - 109. (117 aa) |
| | tag | Similar to E. coli 3-methyl-adenine DNA glycosylase I, constitutive (AAC76573.1); Blastp hit to AAC76573.1 (187 aa), 85% identity in aa 1 - 186. (193 aa) |
| | yhjK | Putative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC76554.1); Blastp hit to AAC76554.1 (651 aa), 84% identity in aa 1 - 651. (657 aa) |
| | kdgK | Similar to E. coli ketodeoxygluconokinase (AAC76551.1); Blastp hit to AAC76551.1 (382 aa), 92% identity in aa 74 - 381. (309 aa) |
| | treF | Cytoplasmic trehalase; Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity. (549 aa) |
| | STM3598 | Similar to E. coli periplasmic L-asparaginase II (AAC75994.1); Blastp hit to AAC75994.1 (348 aa), 46% identity in aa 22 - 348. (347 aa) |
| | gor | Similar to E. coli glutathione oxidoreductase (AAC76525.1); Blastp hit to AAC76525.1 (450 aa), 94% identity in aa 1 - 450. (450 aa) |
| | tcp | Methyl-accepting transmembrane citrate/phenol chemoreceptor; Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes. (547 aa) |
| | rtcB | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76446.1); Blastp hit to AAC76446.1 (408 aa), 87% identity in aa 1 - 408. (405 aa) |
| | ompR | Response regulator in two-component regulatory system with EnvZ; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity). (239 aa) |
| | envZ | Sensory histidine kinase in two-component regulatory system with OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (By similarity). EnvZ functions as a membrane- associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (By similarity). (450 aa) |
| | yrfH | Heat shock protein; Predicted small RNA-binding protein; similar to E. coli orf, hypothetical protein (AAC76425.1); Blastp hit to AAC76425.1 (133 aa), 95% identity in aa 1 - 133; Belongs to the HSP15 family. (133 aa) |
| | yrfG | Similar to E. coli putative phosphatase (AAC76424.1); Blastp hit to AAC76424.1 (237 aa), 85% identity in aa 16 - 237. (222 aa) |
| | dam | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. (278 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (252 aa) |
| | arcB | Sensory histidine kinase in two-component regulatory system with ArcA; Senses redox conditions; similar to E. coli aerobic respiration sensor-response protein; histidine protein kinase/phosphatase, sensor for arcA (AAC76242.1); Blastp hit to AAC76242.1 (776 aa), 93% identity in aa 1 - 776. (778 aa) |
| | deaD | Cysteine sulfinate desulfinase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (646 aa) |
| | aer | Aerotaxis sensor receptor; Senses cellular redox state or proton motive force; similar to E. coli aerotaxis sensor receptor, flavoprotein (AAC76107.1); Blastp hit to AAC76107.1 (506 aa), 83% identity in aa 1 - 506. (506 aa) |
| | STM3216 | Similar to E. coli methyl-accepting chemotaxis protein I, serine sensor receptor (AAC77311.1); Blastp hit to AAC77311.1 (551 aa), 36% identity in aa 2 - 523. (521 aa) |
| | yqjH | Putative transporter; Similar to E. coli orf, hypothetical protein (AAC76105.1); Blastp hit to AAC76105.1 (254 aa), 72% identity in aa 6 - 254. (255 aa) |
| | mug | G/U mismatch specific DNA glycosylase; Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells; Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. (168 aa) |
| | ygiY | Putative sensory histidine kinase in regulatory system; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation (By similarity). (449 aa) |
| | ygiX | Putative transcriptional regulator; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of flhDC (By similarity). (219 aa) |
| | STM3152 | Similar to E. coli methyl-accepting chemotaxis protein I, serine sensor receptor (AAC77311.1); Blastp hit to AAC77311.1 (551 aa), 43% identity in aa 1 - 551. (547 aa) |
| | STM3138 | Similar to E. coli methyl-accepting chemotaxis protein I, serine sensor receptor (AAC77311.1); Blastp hit to AAC77311.1 (551 aa), 30% identity in aa 319 - 463. (352 aa) |
| | iraD | Putative cytoplasmic protein; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway. (126 aa) |
| | yggX | Putative cytoplasmic protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress. (91 aa) |
| | mutY | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. (350 aa) |
| | sprT | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75981.1); Blastp hit to AAC75981.1 (165 aa), 90% identity in aa 1 - 164; Belongs to the SprT family. (165 aa) |
| | yggE | Putative periplasmic immunogenic protein; Similar to E. coli putative actin (AAC75959.1); Blastp hit to AAC75959.1 (246 aa), 88% identity in aa 1 - 245. (248 aa) |
| | recJ | ssDNA exonuclease; Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available. (577 aa) |
| | mutH | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. (231 aa) |
| | recC | Exonuclease V, subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzy [...] (1123 aa) |
| | recB | Exonuclease V, beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoe [...] (1181 aa) |
| | recD | Exonuclease V, alpha chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] (611 aa) |
| | barA | Sensory histidine kinase; Similar to E. coli sensor-regulator, activates OmpR by phophorylation (AAC75828.1); Blastp hit to AAC75828.1 (918 aa), 90% identity in aa 1 - 918. (918 aa) |
| | mutS | Methyl-directed mismatch repair; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (855 aa) |
| | hilA | Invasion genes transcription activator; The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of InvF. Also binds upstream of prgH and directly activates the expression of prgHIJK operon. (553 aa) |
| | fhlA | Formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons; Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. (692 aa) |
| | ygaA | Putative EBP family regulator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. (506 aa) |
| | recA | DNA strand exchange and recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. (353 aa) |
| | proV | Glycine/betaine/proline transport protein; Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for energy coupling to the transport system. (400 aa) |
| | STM2804 | Putative cytoplasmic protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (143 aa) |
| | tctD | Tricarboxylic transport regulatory protein; Transcriptional activator of the tctI tricarboxylate transport system operon. (224 aa) |
| | tctE | Tricarboxylic transport regulatory protein; Similar to E. coli putative 2-component sensor protein (AAC76062.1); Blastp hit to AAC76062.1 (449 aa), 30% identity in aa 160 - 447, 29% identity in aa 1 - 56. (471 aa) |
| | virK | virK-like protein; Similar to virK in Shigella; virulence gene; similar to E. coli putative enzyme (AAC73964.1); Blastp hit to AAC73964.1 (330 aa), 39% identity in aa 47 - 329. (309 aa) |
| | STM2767 | Putative superfamily I DNA and RNA helicase. (660 aa) |
| | STM2730 | Fels-2 prophage protein; Similar to retron in E coli; similar to E. coli DNA adenine methylase (AAC76412.1); Blastp hit to AAC76412.1 (278 aa), 46% identity in aa 8 - 266. (285 aa) |
| | STM2727 | Fels-2 prophage protein; Similar to protein in phage 186, and to retron in E coli; similar to E. coli damage-inducible protein I (AAC74145.1); Blastp hit to AAC74145.1 (81 aa), 29% identity in aa 1 - 77. (101 aa) |
| | recN | Protein used in recombination and DNA repair; May be involved in recombinational repair of damaged DNA. (553 aa) |
| | yfiN | Putative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC75653.1); Blastp hit to AAC75653.1 (408 aa), 75% identity in aa 2 - 405. (406 aa) |
| | clpB | ATP-dependent protease; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Required for colonization of the gastroi [...] (857 aa) |
| | ung | uracil-DNA-glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (229 aa) |
| | recO | Gap repair gene; Involved in DNA repair and RecF pathway recombination; Belongs to the RecO family. (242 aa) |
| | yfhK | Putative sensory kinase in regulatory system; Similar to E. coli putative 2-component sensor protein (AAC75609.1); Blastp hit to AAC75609.1 (496 aa), 87% identity in aa 19 - 496. (480 aa) |
| | yfhA | EBP family; similar to E. coli putative 2-component transcriptional regulator (AAC75607.1); Blastp hit to AAC75607.1 (444 aa), 95% identity in aa 1 - 444. (445 aa) |
| | cadC | OmpR family; similar to E. coli transcriptional activator of cad operon (AAC77094.1); Blastp hit to AAC77094.1 (512 aa), 58% identity in aa 1 - 512. (514 aa) |
| | hmpA | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa) |
| | suhB | Inositol monophosphatase; Similar to E. coli enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action (AAC75586.1); Blastp hit to AAC75586.1 (267 aa), 97% identity in aa 1 - 267; Belongs to the inositol monophosphatase superfamily. (267 aa) |
| | bcp | Thioredoxin dependent thiol peroxidase; Similar to E. coli bacterioferritin comigratory protein (AAC75533.1); Blastp hit to AAC75533.1 (156 aa), 98% identity in aa 1 - 156. (156 aa) |
| | narQ | Similar to E. coli sensor for nitrate reductase system, protein histidine kinase (acts on NarP and narL) (AAC75522.1); Blastp hit to AAC75522.1 (566 aa), 88% identity in aa 3 - 565. (566 aa) |
| | STM2446 | Putative iron-dependent peroxidase; Similar to E. coli orf, hypothetical protein (AAC75484.1); Blastp hit to AAC75484.1 (308 aa), 94% identity in aa 10 - 308. (299 aa) |
| | lig | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (671 aa) |
| | mntH | Manganese/divalent cation transport protein; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake; Belongs to the NRAMP family. (413 aa) |
| | pgtB | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. (668 aa) |
| | pgtA | Activator protein; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. When activated by PgtB it acts in conjunction with sigma-54 as a transcriptional activator. (415 aa) |
| | STM2314 | Putative chemotaxis signal transduction protein; Similar to E. coli positive regulator of CheA protein activity (AAC74957.1); Blastp hit to AAC74957.1 (167 aa), 25% identity in aa 18 - 151. (333 aa) |
| | rcsC | Sensory histidine kinase in two-component regulatory system with RcsB; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (948 aa) |
| | rcsB | LuxR/UhpA family response regulator in two-component regulatory system with RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa) |
| | yojN | Putative sensor/kinase in regulatory system; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (889 aa) |
| | ada | O6-methylguanine-DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated; In the C-terminal section; belongs to the MGMT family. (353 aa) |
| | alkB | DNA repair system specific for alkylated DNA; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha- ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents) (B [...] (216 aa) |
| | narP | Response regulator in two-component regulatory system with NarQ (or NarX); Similar to E. coli nitrate/nitrite response regulator (sensor NarQ) (AAC75253.1); Blastp hit to AAC75253.1 (215 aa), 88% identity in aa 1 - 215. (215 aa) |
| | setB | Proton efflux pump; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose (By similarity); Belongs to the major facilitator superfamily. Set transporter family. (393 aa) |
| | nfo | Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (285 aa) |
| | yeiG | Putative esterase; Serine hydrolase involved in the detoxification of formaldehyde. (285 aa) |
| | yehU | Putative sensor/kinase in regulatory system; Similar to E. coli putative 2-component sensor protein (AAC75187.1); Blastp hit to AAC75187.1 (561 aa), 91% identity in aa 1 - 561. (561 aa) |
| | yehT | Putative regulator; Member of the two-component regulatory system BtsS/BtsR. BtsR regulates expression of btsT by binding to its promoter region. (239 aa) |
| | baeR | OmpR family; similar to E. coli transcriptional response regulatory protein (sensor BaeS) (AAC75140.1); Blastp hit to AAC75140.1 (240 aa), 96% identity in aa 1 - 240. (240 aa) |
| | baeS | Sensory kinase in two-component regulatoyr system wtih BaeR; Similar to E. coli sensor protein (for BaeR) (AAC75139.1); Blastp hit to AAC75139.1 (467 aa), 88% identity in aa 1 - 467. (467 aa) |
| | alkA | Inducible; similar to E. coli 3-methyl-adenine DNA glycosylase II, inducible (AAC75129.1); Blastp hit to AAC75129.1 (282 aa), 74% identity in aa 1 - 279. (289 aa) |
| | sbcB | 3' --> 5' specific; deoxyribophosphodiesterase; similar to E. coli exonuclease I, 3' --> 5' specific; deoxyribophosphodiesterase (AAC75072.1); Blastp hit to AAC75072.1 (475 aa), 93% identity in aa 8 - 475. (476 aa) |
| | umuD | Error-prone repair: SOS-response transcriptional repressor; Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template. (139 aa) |
| | umuC | Error-prone repair protein; Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template. (422 aa) |
| | vsr | DNA mismatch endonuclease; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. (156 aa) |
| | uvrY | Putative LuxR/UhpA family response regulator; Similar to E. coli putative 2-component transcriptional regulator (AAC74981.1); Blastp hit to AAC74981.1 (218 aa), 96% identity in aa 1 - 218. (218 aa) |
| | uvrC | UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (610 aa) |
| | cheA | Sensory histitine protein kinase; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY. (671 aa) |
| | cheW | Purine-binding chemotaxis protein; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. (167 aa) |
| | cheM | Methyl accepting chemotaxis protein II; Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar mediates taxis away from the repellents cobalt and nickel. Unlike in E.coli tar, it does not mediates maltose taxis. (553 aa) |
