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cpdB cpdB STM4421 STM4421 deoC deoC deoB deoB deoD deoD STM4104 STM4104 yjaD yjaD yjfR yjfR sgaH sgaH sgaU sgaU sgaE sgaE STM0033 STM0033 rihC rihC nadC nadC pfs pfs dgt dgt rnhB rnhB rnhA rnhA xseB xseB ushA ushA allA allA allB allB allC allC nfnB nfnB rna rna ybeK ybeK hpaC hpaC hpaB hpaB hpaG hpaG hpaE hpaE hpaI hpaI rne rne add add rnb rnb STM2176 STM2176 cdd cdd preT preT yeiA yeiA yfcF yfcF xseA xseA STM2755 STM2755 csrA csrA surE surE mazG mazG ygdP ygdP yggV yggV deaD deaD pnp pnp STM3334 STM3334 STM3516 STM3516 sgbH sgbH yibF yibF dut dut rph rph gppA gppA rhlB rhlB udp udp fadA fadA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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cpdB2',3'-cyclic-nucleotide 2'-phosphodiesterase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5'-nucleotidase family. (647 aa)
STM4421Similar to E. coli phenylacetaldehyde dehydrogenase (AAC74467.1); Blastp hit to AAC74467.1 (500 aa), 34% identity in aa 22 - 500. (501 aa)
deoC2-deoxyribose-5-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (265 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
deoDSimilar to E. coli purine-nucleoside phosphorylase (AAC77337.1); Blastp hit to AAC77337.1 (239 aa), 96% identity in aa 1 - 239. (239 aa)
STM4104Putative 5'-nucleotidase; Related esterase; similar to E. coli UDP-sugar hydrolase (5'-nucleotidase) (AAC73582.1); Blastp hit to AAC73582.1 (550 aa), 25% identity in aa 34 - 253, 28% identity in aa 383 - 506; 2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. (518 aa)
yjaDPutative NTP pyrophosphohydrolases containing a Zn-finger; Probably nucleic-acid-binding; NADH pyrophosphatase. (SW:NUDC_SALTY). (257 aa)
yjfRPutative Zn-dependent hydrolases of the beta-lactamase fold; Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3- keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions; Belongs to the UlaG family. (354 aa)
sgaHPutative hexulose phosphate synthase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (216 aa)
sgaUPutative hexulose-6-phosphate isomerase; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization; Belongs to the L-ribulose-5-phosphate 3-epimerase family. (284 aa)
sgaEPutative L-ribulose 5-phosphate 4-epimerase; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization. (228 aa)
STM0033Putative 5'-nucleotidase; Similar to E. coli UDP-sugar hydrolase (5'-nucleotidase) (AAC73582.1); Blastp hit to AAC73582.1 (550 aa), 26% identity in aa 1 - 253, 32% identity in aa 386 - 506; Belongs to the 5'-nucleotidase family. (523 aa)
rihCPutative purine nucleoside hydrolase; Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity. (306 aa)
nadCQuinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (297 aa)
pfs5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] (232 aa)
dgtDeoxyguanosine triphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa)
rnhBRNAse HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (198 aa)
rnhARNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (155 aa)
xseBExonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
ushAUDP-sugar hydrolase 5'-nucleotidase; Silent protein USHA(0) precursor. (SW:USHA_SALTY); Belongs to the 5'-nucleotidase family. (550 aa)
allAUreidoglycolate hydrolase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source. (160 aa)
allBAllantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa)
allCAllantoate amidohydrolase; Similar to E. coli putative hydantoin utilization protein (AAC73618.1); Blastp hit to AAC73618.1 (411 aa), 88% identity in aa 1 - 411. (411 aa)
nfnBDihydropteridine reductase; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone (By similarity). (217 aa)
rnaSimilar to E. coli RNase I, cleaves phosphodiester bond between any two nucleotides (AAC73712.1); Blastp hit to AAC73712.1 (268 aa), 73% identity in aa 1 - 268; Belongs to the RNase T2 family. (268 aa)
ybeKPutative purine nucleoside hydrolase; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. (311 aa)
hpaC4-hydroxyphenylacetate catabolism protein; Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component or to other electron acceptors such as cytochrome c and Fe(3+) ion (By similarity); Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily. (170 aa)
hpaB4-hydroxyphenylacetate catabolism protein. (520 aa)
hpaG4-hydroxyphenylacetate catabolism protein; Similar to E. coli putative isomerase (AAC74264.1); Blastp hit to AAC74264.1 (219 aa), 38% identity in aa 22 - 219, 29% identity in aa 35 - 211. (429 aa)
hpaE4-hydroxyphenylacetate catabolism protein; Similar to E. coli aldehyde dehydrogenase, prefers NADP over NAD (AAC74382.1); Blastp hit to AAC74382.1 (495 aa), 39% identity in aa 23 - 493. (488 aa)
hpaI4-hydroxyphenylacetate catabolism protein; Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde. (263 aa)
rneRNase E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1067 aa)
addSimilar to E. coli adenosine deaminase (AAC74695.1); Blastp hit to AAC74695.1 (333 aa), 90% identity in aa 1 - 331; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa)
rnbRNase II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. (644 aa)
STM2176Putative glutathione S-transferase; Similar to E. coli regulator of transcription; stringent starvation protein A (AAC76261.1); Blastp hit to AAC76261.1 (212 aa), 28% identity in aa 11 - 206. (214 aa)
cddCytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
preTPutative NADPH-dependent glutamate synthase beta chain or related oxidoreductase; Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity). (413 aa)
yeiAPutative dihydropyrimidine dehydrogenase; Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity). (411 aa)
yfcFPutative glutathione-S-transferase; Similar to E. coli orf, hypothetical protein (AAC75361.1); Blastp hit to AAC75361.1 (214 aa), 80% identity in aa 1 - 214. (214 aa)
xseAExonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (449 aa)
STM2755Similar to E. coli probable hexulose-6-phosphate synthase (AAC77153.1); Blastp hit to AAC77153.1 (216 aa), 33% identity in aa 6 - 213. (211 aa)
csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
surESurvival protein, protein damage control; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (253 aa)
mazGPutative pyrophosphatase; Similar to E. coli orf, hypothetical protein (AAC75823.1); Blastp hit to AAC75823.1 (263 aa), 93% identity in aa 2 - 263. (266 aa)
ygdPPutative invasion protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (176 aa)
yggVPutative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
deaDCysteine sulfinate desulfinase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (646 aa)
pnpPolynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. Is a global regulator of virulence and persistency. (711 aa)
STM3334Similar to E. coli cytosine deaminase (AAC73440.1); Blastp hit to AAC73440.1 (427 aa), 83% identity in aa 1 - 427. (426 aa)
STM3516Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73329.1); Blastp hit to AAC73329.1 (92 aa), 78% identity in aa 1 - 91. (91 aa)
sgbHPutative 3-hexulose-6-phosphate isomerase; Similar to E. coli probable 3-hexulose 6-phosphate synthase (AAC76605.1); Blastp hit to AAC76605.1 (220 aa), 90% identity in aa 1 - 220. (220 aa)
yibFSimilar to E. coli putative S-transferase (AAC76616.1); Blastp hit to AAC76616.1 (202 aa), 86% identity in aa 1 - 202. (202 aa)
dutDeoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa)
rphRNase PH; Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates. (238 aa)
gppAGuanosine pentaphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (493 aa)
rhlBPutative helicase; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (421 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). (253 aa)
fadA3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity). (387 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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