STRINGSTRING
STM4068 STM4068 STM3358 STM3358 STM3357 STM3357 yhcK yhcK STM3084 STM3084 STM2803 STM2803 ygaE ygaE ptsJ ptsJ STM2275 STM2275 yegW yegW fadR fadR ydcR ydcR yncC yncC STM3602 STM3602 lldR lldR STM3785 STM3785 dgoR dgoR STM1541 STM1541 ydfH ydfH hutC hutC phnR phnR yieP yieP pdhR pdhR uxuR uxuR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STM4068Putative gntR family regulatory protein; Similar to E. coli transcriptional regulator of succinylCoA synthetase operon (AAC73824.1); Blastp hit to AAC73824.1 (240 aa), 28% identity in aa 5 - 220. (240 aa)
STM3358Putative gntR family regulatory protein. (209 aa)
STM3357Putative gntR family regulatory protein; Similar to E. coli orf, hypothetical protein (AAC74613.1); Blastp hit to AAC74613.1 (228 aa), 23% identity in aa 15 - 214. (221 aa)
yhcKPutative gntR family regulatory protein; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. (263 aa)
STM3084Putative gntR family regulatory protein; Similar to E. coli regulator for uxu operon (AAC77280.1); Blastp hit to AAC77280.1 (257 aa), 39% identity in aa 8 - 247. (266 aa)
STM2803Putative gntR family regulatory protein; Similar to E. coli putative regulator (AAC77296.1); Blastp hit to AAC77296.1 (470 aa), 31% identity in aa 119 - 437, 27% identity in aa 1 - 224. (444 aa)
ygaEPutative GntR family transcriptional repressor; Similar to E. coli putative transcriptional regulator (AAC75711.1); Blastp hit to AAC75711.1 (226 aa), 87% identity in aa 10 - 225. (225 aa)
ptsJPutative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] (430 aa)
STM2275Putative gntR family regulatory protein; Similar to E. coli orf, hypothetical protein (AAC74613.1); Blastp hit to AAC74613.1 (228 aa), 25% identity in aa 13 - 217. (294 aa)
yegWPutative gntR family regulatory protein; Similar to E. coli putative transcriptional regulator (AAC75162.1); Blastp hit to AAC75162.1 (248 aa), 92% identity in aa 1 - 248. (248 aa)
fadRNegative regulator of fad regulon; Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds (By similarity). (239 aa)
ydcRPutative gntR family regulatory protein; Similar to E. coli multi modular; putative transcriptional regulator; also putative ATP-binding component of a transport system (AAC74521.1); Blastp hit to AAC74521.1 (468 aa), 87% identity in aa 1 - 468. (474 aa)
yncCPutative gntR family regulatory protein; Similar to E. coli orf, hypothetical protein (AAC74532.1); Blastp hit to AAC74532.1 (240 aa), 58% identity in aa 20 - 238. (221 aa)
STM3602Putative gntR family regulatory protein; Similar to E. coli putative transcriptional regulator (AAC76400.1); Blastp hit to AAC76400.1 (265 aa), 28% identity in aa 27 - 260. (239 aa)
lldRPutative transcriptional GntR family regulator for lct operon; Similar to E. coli transcriptional regulator (AAC76628.1); Blastp hit to AAC76628.1 (258 aa), 86% identity in aa 1 - 258. (258 aa)
STM3785Putative gntR family regulatory protein; Similar to E. coli transcriptional regulator of succinylCoA synthetase operon (AAC73824.1); Blastp hit to AAC73824.1 (240 aa), 31% identity in aa 3 - 216. (247 aa)
dgoRGalactonate operon transcriptional repressor; GntR family; similar to E. coli regulator protein for dgo operon (AAC76718.1); Blastp hit to AAC76718.1 (128 aa), 94% identity in aa 1 - 112. (229 aa)
STM1541Putative gntR family regulatory protein; Similar to E. coli regulator for uxu operon (AAC77280.1); Blastp hit to AAC77280.1 (257 aa), 31% identity in aa 8 - 229. (263 aa)
ydfHPutative gntR family regulatory protein; Similar to E. coli orf, hypothetical protein (AAC74613.1); Blastp hit to AAC74613.1 (228 aa), 86% identity in aa 1 - 228. (228 aa)
hutCHistidine utilization repressor; Similar to E. coli transcriptional regulator of succinylCoA synthetase operon (AAC73824.1); Blastp hit to AAC73824.1 (240 aa), 24% identity in aa 5 - 229. (241 aa)
phnR2-aminoethylphosphonate transport, repressor; Probable repressor protein of GntR family phnR (gi|11354257). (239 aa)
yiePPutative gntR family regulatory protein; Similar to E. coli orf, hypothetical protein (AAC76778.1); Blastp hit to AAC76778.1 (181 aa), 82% identity in aa 1 - 181. (234 aa)
pdhRTranscriptional repressor for pyruvate dehydrogenase complex (GntR family); Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd. (254 aa)
uxuRSimilar to E. coli regulator for uxu operon (AAC77280.1); Blastp hit to AAC77280.1 (257 aa), 89% identity in aa 1 - 257. (257 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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