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amiC amiC hypO hypO sufI sufI msrP msrP torA torA fdoG fdoG nrfC nrfC STM0084 STM0084 cueO cueO STM0611 STM0611 dmsA dmsA ycbK ycbK ttrB ttrB STM1498 STM1498 STM1499 STM1499 STM1539 STM1539 fdnG fdnG ydcG ydcG STM1786 STM1786 phsA phsA wcaM wcaM napG napG napA napA STM2530 STM2530 hybA hybA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
amiCSimilar to E. coli putative amidase (AAC75856.1); Blastp hit to AAC75856.1 (447 aa), 94% identity in aa 31 - 446. (417 aa)
hypOPutative Ni/Fe hydrogenases, small subunit; Similar to E. coli putative hydrogenase subunit (AAC76033.1); Blastp hit to AAC76033.1 (372 aa), 96% identity in aa 1 - 372. (372 aa)
sufISuppressor of ftsI; Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress. (470 aa)
msrPPutative nitrate reductase; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The cata [...] (334 aa)
torATrimethylamine N-oxide reductase subunit; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. (850 aa)
fdoGSimilar to E. coli formate dehydrogenase-O, major subunit (AAD13456.1); Blastp hit to AAD13456.1 (1016 aa), 93% identity in aa 1 - 1016. (1016 aa)
nrfCFe-S centers; similar to E. coli formate-dependent nitrite reductase; Fe-S centers (AAC77042.1); Blastp hit to AAC77042.1 (223 aa), 91% identity in aa 1 - 223. (223 aa)
STM0084Similar to E. coli putative sulfatase (AAC76701.1); Blastp hit to AAC76701.1 (497 aa), 31% identity in aa 251 - 345, 31% identity in aa 5 - 103, 45% identity in aa 400 - 431. (629 aa)
cueOPutative multicopper oxidase; Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm (By similarity). (536 aa)
STM0611Similar to E. coli putative oxidoreductase, major subunit (AAC74659.1); Blastp hit to AAC74659.1 (808 aa), 31% identity in aa 10 - 314, 26% identity in aa 298 - 673, 36% identity in aa 636 - 765, 34% identity in aa 489 - 517; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
dmsASimilar to E. coli anaerobic dimethyl sulfoxide reductase subunit A (AAC73980.1); Blastp hit to AAC73980.1 (785 aa), 93% identity in aa 1 - 784; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (814 aa)
ycbKPutative outer membrane protein; Similar to E. coli orf, hypothetical protein (AAC74012.1); Blastp hit to AAC74012.1 (182 aa), 95% identity in aa 1 - 182. (182 aa)
ttrBTetrathionate reductase complex, subunit B; Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate. TtrB is probably involved in transfer of electrons from TtrC to TtrA. During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S.typhimurium over the competing microbiota in the lumen of the inflamed gut. (250 aa)
STM1498Similar to E. coli putative oxidoreductase, major subunit (AAC74660.1); Blastp hit to AAC74660.1 (808 aa), 91% identity in aa 2 - 807; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (811 aa)
STM1499Putative dimethyl sulphoxide reductase, chain A1; Similar to E. coli putative oxidoreductase, major subunit (AAC74659.1); Blastp hit to AAC74659.1 (808 aa), 86% identity in aa 1 - 808; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (813 aa)
STM1539Similar to E. coli hydrogenase-1 small subunit (AAC74057.1); Blastp hit to AAC74057.1 (372 aa), 72% identity in aa 1 - 371. (367 aa)
fdnGPutative molybdopterin oxidoreductases; Similar to E. coli formate dehydrogenase-N, nitrate-inducible, alpha subunit (AAD13438.1); Blastp hit to AAD13438.1 (1015 aa), 93% identity in aa 1 - 1015; contains selenocysteine tRNA suppressible codon. (1015 aa)
ydcGPutative periplasmic glucans biosynthesis protein; Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs); Belongs to the OpgD/OpgG family. (551 aa)
STM1786Similar to E. coli hydrogenase-1 small subunit (AAC74057.1); Blastp hit to AAC74057.1 (372 aa), 92% identity in aa 1 - 372. (372 aa)
phsAHydrogen sulfide production membrane anchoring protein; Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsA subunit contains the active site molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor. (758 aa)
wcaMColanic acid biosynthesis protein WCAM. (SW:WCAM_SALTY). (467 aa)
napGFerredoxin-type protein; Electron transfer; similar to E. coli ferredoxin-type protein: electron transfer (AAC75265.1); Blastp hit to AAC75265.1 (231 aa), 94% identity in aa 1 - 231. (231 aa)
napAPeriplasmic large subunit nitrate reductase; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
STM2530Similar to E. coli putative oxidoreductase, major subunit (AAC74660.1); Blastp hit to AAC74660.1 (808 aa), 42% identity in aa 15 - 807; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (801 aa)
hybAUnknown; Intitally thought to be hydrogenase-2 small subunit which now identified as hybO; similar to E. coli hydrogenase-2 small subunit (AAC76032.1); Blastp hit to AAC76032.1 (328 aa), 95% identity in aa 1 - 328. (328 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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