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| | STM3966 | Similar to E. coli putative arylsulfatase regulator (AAC76803.1); Blastp hit to AAC76803.1 (411 aa), 47% identity in aa 11 - 402. (447 aa) |
| | hemN | O2-independent coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX. (457 aa) |
| | STM4011 | Putative inner membrane protein. (292 aa) |
| | yihT | Putative aldolase; Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). Belongs to the aldolase LacD family. (292 aa) |
| | yneB | Putative fructose-1,6-bisphosphate aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA. (291 aa) |
| | lsrE | Similar to E. coli D-ribulose-5-phosphate 3-epimerase (AAC76411.1); Blastp hit to AAC76411.1 (225 aa), 26% identity in aa 1 - 217. (254 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | talC | Putative transaldolase; Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction; Belongs to the transaldolase family. Type 3A subfamily. (220 aa) |
| | pflC | Similar to E. coli probable pyruvate formate lyase activating enzyme 2 (AAC76934.1); Blastp hit to AAC76934.1 (292 aa), 78% identity in aa 1 - 292. (292 aa) |
| | thiH | Thiamin biosynthesis protein, thiazole moiety; Catalyzes the radical-mediated cleavage of tyrosine to 2- iminoacetate and 4-cresol; Belongs to the radical SAM superfamily. ThiH family. (377 aa) |
| | thiG | Thiamin biosynthesis protein, thiazole moiety; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiE | Thiamin phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | yjbN | Putative TIM-barrel enzyme; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (332 aa) |
| | yjeK | Putative aminomutase; With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2,3- aminomutase activity, producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine) (By similarity). (342 aa) |
| | sgaH | Putative hexulose phosphate synthase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (216 aa) |
| | STM4429 | Putative cytoplasmic protein. (266 aa) |
| | STM4430 | Putative sugar kinase; Ribokinase family. (645 aa) |
| | STM4447 | Putative periplasmic protein. (246 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. Belongs to the type-I 3-dehydroquinase family. (252 aa) |
| | nemA | Similar to E. coli N-ethylmaleimide reductase (AAC74722.1); Blastp hit to AAC74722.1 (365 aa), 92% identity in aa 1 - 365. (365 aa) |
| | STM1617 | Putative ribulose-phosphate 3-epimerase; Similar to E. coli putative epimerase (AAC77257.1); Blastp hit to AAC77257.1 (210 aa), 65% identity in aa 1 - 210. (210 aa) |
| | STM1620 | Putative oxidase; Similar to E. coli L-lactate dehydrogenase (AAC76629.1); Blastp hit to AAC76629.1 (396 aa), 38% identity in aa 212 - 384, 33% identity in aa 22 - 175. (400 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa) |
| | trpC | N-(5-phosphoribosyl)anthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). (452 aa) |
| | trpA | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. (268 aa) |
| | kdsA | 3-deoxy-D-manno-octulosonic acid 8-P synthetase; Similar to E. coli 2-dehydro-3-deoxyphosphooctulonate aldolase (AAC74299.1); Blastp hit to AAC74299.1 (284 aa), 93% identity in aa 1 - 282; Belongs to the KdsA family. (284 aa) |
| | eda | Multifunctional; similar to E. coli 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase (AAC74920.1); Blastp hit to AAC74920.1 (213 aa), 97% identity in aa 1 - 212; oxaloacetate decarboxylase. (213 aa) |
| | hisA | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotideisomerase. (SW:HIS4_SALTY). (245 aa) |
| | hisF | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (258 aa) |
| | fbaB | 3-oxoacyl-[acyl-carrier-protein] synthase I; Similar to E. coli orf, hypothetical protein (AAC75158.1); Blastp hit to AAC75158.1 (374 aa), 96% identity in aa 25 - 374. (350 aa) |
| | yohI | Putative nitrogen regulation protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (312 aa) |
| | yeiA | Putative dihydropyrimidine dehydrogenase; Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity). (411 aa) |
| | eutB | Ethanolamine ammonia-lyase, heavy chain; Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. (453 aa) |
| | talA | Transaldolase A; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | yfgB | Putative Fe-S-cluster redox enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (388 aa) |
| | pdxJ | Carries out condensation and ring closure step after PdxA in pyridoxine biosynthesis; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa) |
| | aroF | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP); Belongs to the class-I DAHP synthase family. (356 aa) |
| | STM2755 | Similar to E. coli probable hexulose-6-phosphate synthase (AAC77153.1); Blastp hit to AAC77153.1 (216 aa), 33% identity in aa 6 - 213. (211 aa) |
| | ygcF | Putative organic radical activating enzymes; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | fba | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | yggW | Putative oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa) |
| | STM3123 | Similar to E. coli putative arylsulfatase regulator (AAC76803.1); Blastp hit to AAC76803.1 (411 aa), 36% identity in aa 4 - 248, 34% identity in aa 230 - 387. (394 aa) |
| | fadH | 2,4-dieonyl-coa reductase; Similar to E. coli putative NADPH dehydrogenase (AAC76116.1); Blastp hit to AAC76116.1 (672 aa), 85% identity in aa 1 - 672. (672 aa) |
| | gatY | Putative fructose/tagatose biphosphate aldolase; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. (284 aa) |
| | gatZ | Putative tagatose 6-phosphate kinase 1; Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol. (423 aa) |
| | gltB | Similar to E. coli glutamate synthase, large subunit (AAC76244.1); Blastp hit to AAC76244.1 (1517 aa), 95% identity in aa 32 - 1517. (1486 aa) |
| | nanE | Putative ManNAc-6P epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (229 aa) |
| | nanA | N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (297 aa) |
| | nrdG | Anaerobic ribonucleotide reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (154 aa) |
| | pflA | Pyruvate formate lyase activating enzyme 1; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (274 aa) |
| | yjjW | Pyruvate formate lyase activating enzyme; Similar to E. coli putative activating enzyme (AAC77332.1); Blastp hit to AAC77332.1 (287 aa), 81% identity in aa 1 - 287. (287 aa) |
| | deoC | 2-deoxyribose-5-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (265 aa) |
| | hemB | Similar to E. coli 5-aminolevulinate dehydratase = porphobilinogen synthase (AAC73472.1); Blastp hit to AAC73472.1 (335 aa), 93% identity in aa 12 - 335; Belongs to the ALAD family. (324 aa) |
| | lipA | Lipoate synthase, an iron-sulfur enzyme; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | aroG | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, phenylalanine repressible); Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa) |
| | bioB | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa) |
| | moaA | Molybdopterin biosynthesis, protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa) |
| | pflE | Similar to E. coli putative pyruvate formate-lyase 2 activating enzyme (AAC73911.1); Blastp hit to AAC73911.1 (308 aa), 87% identity in aa 10 - 308. (299 aa) |
| | talB | Transaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa) |
| | yhdG | Putative TIM-barrel enzyme; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (321 aa) |
| | STM0036 | Similar to E. coli putative arylsulfatase regulator (AAC76803.1); Blastp hit to AAC76803.1 (411 aa), 46% identity in aa 8 - 401. (396 aa) |
| | oadA1 | Putative oxalacetate decarboxylase, subunit alpha; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (591 aa) |
| | nadC | Quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (297 aa) |
| | guaC | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa) |
| | STM1287 | Similar to E. coli putative arylsulfatase regulator (AAC76803.1); Blastp hit to AAC76803.1 (411 aa), 46% identity in aa 10 - 401. (398 aa) |
| | aroH | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa) |
| | nanE1 | Putative inner membrane protein; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (226 aa) |
| | pyrD | Dihydro-orotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa) |
| | rpe | Similar to E. coli D-ribulose-5-phosphate 3-epimerase (AAC76411.1); Blastp hit to AAC76411.1 (225 aa), 97% identity in aa 1 - 224; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | STM3532 | Putative dihydrodipicolinate synthetase; Similar to E. coli putative lyase/synthase (AAC73371.1); Blastp hit to AAC73371.1 (309 aa), 43% identity in aa 8 - 308; Belongs to the DapA family. (301 aa) |
| | sgbH | Putative 3-hexulose-6-phosphate isomerase; Similar to E. coli probable 3-hexulose 6-phosphate synthase (AAC76605.1); Blastp hit to AAC76605.1 (220 aa), 90% identity in aa 1 - 220. (220 aa) |
| | lldD | L-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa) |
| | STM3767 | Putative cytoplasmic protein. (247 aa) |
| | STM3780 | Putative fructose-bisphosphate aldolase class-II; Similar to E. coli tagatose-bisphosphate aldolase 2 (AAC76171.1); Blastp hit to AAC76171.1 (286 aa), 36% identity in aa 1 - 277. (286 aa) |
| | yidF | Putative cytoplasmic protein; Similar to E. coli putative transcriptional regulator (AAC76697.1); Blastp hit to AAC76697.1 (165 aa), 48% identity in aa 1 - 165. (176 aa) |
