STRINGSTRING
STM2446 STM2446 mntH mntH ackA ackA pduW pduW cboQ cboQ ftsI-2 ftsI-2 infC infC rpsT rpsT ftsI ftsI ftsW ftsW ftsQ ftsQ ftsZ ftsZ tsf tsf frr frr nagA nagA poxB poxB ftsK ftsK lsrE lsrE phoU phoU mgtC mgtC pitA pitA ftsE ftsE ftsX ftsX rpe rpe rpsJ rpsJ rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplN rplN pepT pepT rpsH rpsH rpsD rpsD mreD mreD rplM rplM rpsI rpsI rplU rplU rpmA rpmA hflB hflB rpoS rpoS hisS hisS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STM2446Putative iron-dependent peroxidase; Similar to E. coli orf, hypothetical protein (AAC75484.1); Blastp hit to AAC75484.1 (308 aa), 94% identity in aa 10 - 308. (299 aa)
mntHManganese/divalent cation transport protein; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake; Belongs to the NRAMP family. (413 aa)
ackAAcetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. (400 aa)
pduWProbable propionate kinase. (SW:PDUW_SALTY); Belongs to the acetokinase family. PduW subfamily. (404 aa)
cboQSynthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiQ family. (225 aa)
ftsI-2Putative penicillin-binding protein-3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (581 aa)
infCProtein chain initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (144 aa)
rpsT30S ribosomal subunit protein S20; Binds directly to 16S ribosomal RNA. (87 aa)
ftsIDivision specific transpeptidase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (588 aa)
ftsWEssential cell division gene; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa)
ftsQCell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (276 aa)
ftsZTubulin-like GTP-binding protein and GTPase; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
tsfProtein chain elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (283 aa)
frrRibosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
nagASimilar to E. coli N-acetylglucosamine-6-phosphate deacetylase (AAC73771.1); Blastp hit to AAC73771.1 (382 aa), 92% identity in aa 1 - 380. (384 aa)
poxBPyruvate dehydrogenase/oxidase FAD and thiamine PPi cofactors, cytoplasmic in absence of cofactors; Similar to E. coli pyruvate oxidase (AAC73958.1); Blastp hit to AAC73958.1 (572 aa), 94% identity in aa 1 - 572; Belongs to the TPP enzyme family. (572 aa)
ftsKCell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA trans [...] (1351 aa)
lsrESimilar to E. coli D-ribulose-5-phosphate 3-epimerase (AAC76411.1); Blastp hit to AAC76411.1 (225 aa), 26% identity in aa 1 - 217. (254 aa)
phoURegulatory gene for high affinity phosphate uptake; Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. (241 aa)
mgtCMg2+ transport protein; Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase. Belongs to the MgtC/SapB family. (231 aa)
pitAPiT family; similar to E. coli low-affinity phosphate transport (AAC76518.1); Blastp hit to AAC76518.1 (499 aa), 92% identity in aa 1 - 499. (498 aa)
ftsEPutative ATPase involved in cell division; Part of the ABC transporter FtsEX involved in cellular division. (222 aa)
ftsXPutative integral membrane cell division protein; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (351 aa)
rpeSimilar to E. coli D-ribulose-5-phosphate 3-epimerase (AAC76411.1); Blastp hit to AAC76411.1 (225 aa), 97% identity in aa 1 - 224; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa)
rpsJ30S ribosomal subunit protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rplD50S ribosomal subunit protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). Forms part of the polypeptide exit tunnel. Belongs to the universal ribosomal protein uL4 family. (201 aa)
rplW50S ribosomal subunit protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa)
rplB50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rpsS30S ribosomal subunit protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplV50S ribosomal subunit protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (110 aa)
rpsC30S ribosomal subunit protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity). Belongs to the universal ribosomal protein uS3 family. (233 aa)
rplN50S ribosomal subunit protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa)
pepTPutative peptidase T; Cleaves the N-terminal amino acid of tripeptides. Hydrolyzes tripeptides containing N-terminal methionine, leucine, or phenylalanine. Displays little or no activity against dipeptides, N- blocked or C-blocked tripeptides, and tetrapeptides. Belongs to the peptidase M20B family. (409 aa)
rpsH30S ribosomal subunit protein S8, and regulator; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpsD30S ribosomal subunit protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
mreDRod shape-determining protein; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. (163 aa)
rplM50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpsISimilar to E. coli 30S ribosomal subunit protein S9 (AAC76262.1); Blastp hit to AAC76262.1 (130 aa), 99% identity in aa 1 - 130. (130 aa)
rplU50S ribosomal subunit protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpmASimilar to E. coli 50S ribosomal subunit protein L27 (AAC76217.1); Blastp hit to AAC76217.1 (85 aa), 95% identity in aa 1 - 85; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
hflBATP-dependent zinc-metallo protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (644 aa)
rpoSSigma S (sigma 38) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
hisShistidyl-tRNA synthetase. (SW:SYH_SALTY). (424 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (26%) [HD]