STRINGSTRING
oxyR oxyR ahpF ahpF mntR mntR icdA icdA katE katE sodB sodB sfcA sfcA ftnB ftnB mntH mntH recA recA sodA sodA katG katG glpX glpX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
oxyRRegulatory protein sensor for oxidative stress; Regulates intracellular hydrogen peroxide (LysR family); similar to E. coli activator, hydrogen peroxide-inducible genes (AAC76943.1); Blastp hit to AAC76943.1 (305 aa), 95% identity in aa 1 - 305; Belongs to the LysR transcriptional regulatory family. (305 aa)
ahpFAlkyl hydroperoxide reductase, F52a subunit; Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (521 aa)
mntRPutative Mn-dependent transcriptional regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Belongs to the DtxR/MntR family. (157 aa)
icdAIsocitrate dehydrogenase in e14 prophage; Specific for NADP+; similar to E. coli isocitrate dehydrogenase, specific for NADP+ (AAC74220.1); Blastp hit to AAC74220.1 (416 aa), 96% identity in aa 1 - 416. (416 aa)
katECatalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (750 aa)
sodBIron superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (193 aa)
sfcASimilar to E. coli NAD-linked malate dehydrogenase (malic enzyme) (AAC74552.1); Blastp hit to AAC74552.1 (574 aa), 92% identity in aa 10 - 574; Belongs to the malic enzymes family. (565 aa)
ftnBFerritin-like protein; Iron-storage protein. (167 aa)
mntHManganese/divalent cation transport protein; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake; Belongs to the NRAMP family. (413 aa)
recADNA strand exchange and recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. (353 aa)
sodASuperoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (206 aa)
katGCatalase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (726 aa)
glpXSimilar to E. coli unknown function in glycerol metabolism (AAC76907.1); Blastp hit to AAC76907.1 (336 aa), 94% identity in aa 1 - 336. (336 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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