STRINGSTRING
soxR soxR rfaQ rfaQ rfaL rfaL rpoA rpoA yqjA yqjA yghB yghB gcvT gcvT pssA pssA glyA glyA yfcF yfcF pgsA pgsA secA secA folD folD yliJ yliJ gst gst zwf zwf aspA aspA STM4267 STM4267 dnaA dnaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
soxRRedox-sensing transcriptional activator SoxR; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity). (152 aa)
rfaQModification of heptose region of core; similar to E. coli lipopolysaccharide core biosynthesis (AAC76656.1); Blastp hit to AAC76656.1 (344 aa), 78% identity in aa 1 - 344. (344 aa)
rfaLO-antigen ligase; Adds the O-antigen on the glucose(II) group of LPS. (404 aa)
rpoARNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa)
yqjAPutative DedA family membrane protein; Similar to E. coli orf, hypothetical protein (AAC76130.1); Blastp hit to AAC76130.1 (220 aa), 95% identity in aa 1 - 220. (220 aa)
yghBPutative DedA family membrane protein; Hypothetical protein in metC 3'region. (SW:YGHB_SALTY). (219 aa)
gcvTGlycine cleavage complex protein T; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
pssAPhosphatidylserine synthase; CDP-diacylglycerol-serine O-phosphatidyltransferase; similar to E. coli phosphatidylserine synthase; phospholipid synthesis (AAC75638.1); Blastp hit to AAC75638.1 (452 aa), 93% identity in aa 2 - 452. (451 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). (417 aa)
yfcFPutative glutathione-S-transferase; Similar to E. coli orf, hypothetical protein (AAC75361.1); Blastp hit to AAC75361.1 (214 aa), 80% identity in aa 1 - 214. (214 aa)
pgsAPhosphatidylglycerophosphate synthetase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa)
secAPreprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (901 aa)
folD5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa)
yliJPutative glutathione S-transferase; Similar to E. coli putative transferase (AAC73925.1); Blastp hit to AAC73925.1 (210 aa), 82% identity in aa 3 - 210. (208 aa)
gstSimilar to E. coli glutathionine S-transferase (AAC74707.1); Blastp hit to AAC74707.1 (201 aa), 84% identity in aa 1 - 200. (201 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
aspASimilar to E. coli aspartate ammonia-lyase (aspartase) (AAC77099.1); Blastp hit to AAC77099.1 (493 aa), 97% identity in aa 16 - 493. (478 aa)
STM4267Putative glutathione S-transferase; Belongs to the GST superfamily. (222 aa)
dnaADNA replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. DnaA can inhibit its own gene expression as well as that of other genes (By similarity). (466 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (18%) [HD]