node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
invB | invC | STM2895 | STM2894 | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. | 0.998 |
invB | invF | STM2895 | STM2899 | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | 0.930 |
invB | prgJ | STM2895 | STM2872 | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | 0.999 |
invB | sicA | STM2895 | STM2886 | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | Surface presentation of antigens; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | 0.989 |
invB | spaQ | STM2895 | STM2889 | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the FliQ/MopD/SpaQ family. | 0.942 |
invB | sscB | STM2895 | STM1403 | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | Secretion system chaparone; SscB (gi|3377867). | 0.457 |
invC | invB | STM2894 | STM2895 | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | 0.998 |
invC | invF | STM2894 | STM2899 | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. | Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | 0.937 |
invC | prgJ | STM2894 | STM2872 | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | 0.966 |
invC | sicA | STM2894 | STM2886 | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. | Surface presentation of antigens; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | 0.994 |
invC | spaQ | STM2894 | STM2889 | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the FliQ/MopD/SpaQ family. | 0.993 |
invF | invB | STM2899 | STM2895 | Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | 0.930 |
invF | invC | STM2899 | STM2894 | Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. | 0.937 |
invF | prgJ | STM2899 | STM2872 | Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | 0.674 |
invF | sicA | STM2899 | STM2886 | Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | Surface presentation of antigens; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | 0.985 |
invF | spaQ | STM2899 | STM2889 | Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the FliQ/MopD/SpaQ family. | 0.813 |
prgJ | invB | STM2872 | STM2895 | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. | 0.999 |
prgJ | invC | STM2872 | STM2894 | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. | 0.966 |
prgJ | invF | STM2872 | STM2899 | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | 0.674 |
prgJ | sicA | STM2872 | STM2886 | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | Surface presentation of antigens; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. | 0.922 |