STRINGSTRING
sdaA sdaA lysP lysP glpQ glpQ glpT glpT glyA glyA sdaC sdaC fucA fucA speB speB ansB ansB tdcC tdcC tufA tufA glpD glpD dctA dctA lldR lldR lldD lldD yidY yidY pfkA pfkA pyrB pyrB aspA aspA yjdE yjdE fbp fbp glpF glpF glpK glpK glpX glpX pheP pheP bioF bioF bioC bioC pykF pykF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sdaASimilar to E. coli L-serine deaminase (AAC74884.1); Blastp hit to AAC74884.1 (454 aa), 94% identity in aa 1 - 454; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
lysPSimilar to E. coli lysine-specific permease (AAC75217.1); Blastp hit to AAC75217.1 (489 aa), 94% identity in aa 1 - 489. (489 aa)
glpQSimilar to E. coli glycerophosphodiester phosphodiesterase, periplasmic (AAC75299.1); Blastp hit to AAC75299.1 (358 aa), 89% identity in aa 1 - 357. (356 aa)
glpTMFS family, sn-glycerol-3-phosphate transport protein; Similar to E. coli sn-glycerol-3-phosphate permease (AAC75300.1); Blastp hit to AAC75300.1 (452 aa), 96% identity in aa 1 - 452. (452 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). (417 aa)
sdaCPutative HAAAP family serine transport protein; Similar to E. coli probable serine transporter (AAC75838.1); Blastp hit to AAC75838.1 (429 aa), 95% identity in aa 1 - 429. (429 aa)
fucAL-fuculose-1-phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa)
speBAgmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (306 aa)
ansBSimilar to E. coli periplasmic L-asparaginase II (AAC75994.1); Blastp hit to AAC75994.1 (348 aa), 92% identity in aa 1 - 348. (348 aa)
tdcCHAAAP family L-threonine/ L-serine permease; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. (443 aa)
tufAProtein chain elongation factor EF-Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
glpDAerobic; similar to E. coli sn-glycerol-3-phosphate dehydrogenase (aerobic) (AAC76451.1); Blastp hit to AAC76451.1 (501 aa), 90% identity in aa 1 - 501; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (502 aa)
dctADAACS family C4-dicarboxylic acids transport protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (428 aa)
lldRPutative transcriptional GntR family regulator for lct operon; Similar to E. coli transcriptional regulator (AAC76628.1); Blastp hit to AAC76628.1 (258 aa), 86% identity in aa 1 - 258. (258 aa)
lldDL-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa)
yidYPutative MFS family tranport protein; 1st mdule; similar to E. coli putative transport protein (AAC76733.1); Blastp hit to AAC76733.1 (391 aa), 77% identity in aa 1 - 391. (395 aa)
pfkA6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
pyrBAspartate carbamoyltransferase catalytic chain. (SW:PYRB_SALTY). (311 aa)
aspASimilar to E. coli aspartate ammonia-lyase (aspartase) (AAC77099.1); Blastp hit to AAC77099.1 (493 aa), 97% identity in aa 16 - 493. (478 aa)
yjdEPutative APC family putrescine/ornithine transport protein; Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (445 aa)
fbpSimilar to E. coli fructose-bisphosphatase (AAC77189.1); Blastp hit to AAC77189.1 (332 aa), 97% identity in aa 1 - 332. (332 aa)
glpFSimilar to E. coli facilitated diffusion of glycerol (AAC76909.1); Blastp hit to AAC76909.1 (281 aa), 92% identity in aa 1 - 281; Belongs to the MIP/aquaporin (TC 1.A.8) family. (281 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa)
glpXSimilar to E. coli unknown function in glycerol metabolism (AAC76907.1); Blastp hit to AAC76907.1 (336 aa), 94% identity in aa 1 - 336. (336 aa)
phePAPC family, phenylalanene transporter; Similar to E. coli phenylalanine-specific transport system (AAC73677.1); Blastp hit to AAC73677.1 (458 aa), 92% identity in aa 1 - 458. (464 aa)
bioF7-keto-8-aminopelargonic acid synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
bioCBiotin biosynthesis; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa)
pykFPyruvate kinase I; Formerly F; fructose stimulated; pyruvate kinase I. (SW:KPY1_SALTY). (470 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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