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flhB | Putative part of export apparatus for flagellar proteins; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (383 aa) | ||||
spaQ | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the FliQ/MopD/SpaQ family. (86 aa) | ||||
spaS | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the type III secretion exporter family. (356 aa) | ||||
sipB | Cell invasion protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chape [...] (593 aa) | ||||
prgH | Cell invasion protein; Required for invasion of epithelial cells. (392 aa) | ||||
prgJ | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. (101 aa) | ||||
prgK | Cell invasion protein; Required for invasion of epithelial cells. Could be involved in protein secretion; Belongs to the YscJ lipoprotein family. (252 aa) | ||||
orgA | Putative flagellar biosynthesis/type III secretory pathway protein; Oxygen-regulated protein required for bacterial internalization. (226 aa) | ||||
csrA | Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa) | ||||
eutR | Putative regulator ethanolamine operon; Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors. (350 aa) | ||||
rcsB | LuxR/UhpA family response regulator in two-component regulatory system with RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa) | ||||
fliN | Flagellar biosynthesis protein; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). Belongs to the FliN/MopA/SpaO family. (137 aa) | ||||
fliM | Flagellar biosynthesis protein; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). (334 aa) | ||||
fliK | Flagellar hook-length control protein; Controls the length of the flagellar hook. (405 aa) | ||||
fliJ | Flagellar FliJ protein; Flagellar protein that affects chemotactic events. (147 aa) | ||||
fliI | Flagellum-specific ATP synthase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage; Belongs to the ATPase alpha/beta chains family. (456 aa) | ||||
fliH | Flagellar biosynthesis protein; Needed for flagellar regrowth and assembly. (235 aa) | ||||
fliG | Flagellar biosynthesis protein; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). (331 aa) | ||||
fliF | Basal-body MS (membrane and supramembrane)-ring and collar protein; The M ring may be actively involved in energy transduction. (560 aa) | ||||
sdiA | LuxR/UhpA family; similar to E. coli transcriptional regulator of ftsQAZ gene cluster (AAC74983.1); Blastp hit to AAC74983.1 (240 aa), 71% identity in aa 1 - 240. (240 aa) | ||||
flhA | Flagellar biosynthesis protein; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. (692 aa) | ||||
invJ | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the SpaN family. (336 aa) | ||||
invC | Surface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. (431 aa) | ||||
invA | Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (685 aa) | ||||
invE | Invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA. Positively regulates the secretion of SPI-1 TTSS effector proteins SipB, SipC and SipD and negatively influences the secretion of [...] (372 aa) | ||||
invG | Outer membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. (562 aa) | ||||
rpoS | Sigma S (sigma 38) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa) | ||||
ygiY | Putative sensory histidine kinase in regulatory system; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation (By similarity). (449 aa) | ||||
rpoN | Sigma N factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC). (477 aa) | ||||
typA | GTP-binding elongation factor family protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non- hydrolyzable analog [...] (607 aa) | ||||
spaP | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (224 aa) | ||||
hfq | Host factor I for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells. (102 aa) | ||||
pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death (By similarity). (202 aa) | ||||
STM1484 | Putative protease; Similar to E. coli orf, hypothetical protein (AAC74670.1); Blastp hit to AAC74670.1 (273 aa), 77% identity in aa 1 - 272; Belongs to the peptidase S1B family. (273 aa) | ||||
ssaQ | Secretion system apparatus protein; Part of a type III secretion system. (322 aa) | ||||
ssaM | Secretion system apparatus protein SSAM. (SW:SSAM_SALTY). (122 aa) | ||||
ssaL | Secretion system apparatus protein SSAL. (SW:SSAL_SALTY). (338 aa) | ||||
ssaB | Secretion system apparatus protein; Virulence protein that plays a central role in mammalian macrophage infection, by inhibiting phagosome-lysosome fusion and cellular trafficking. May act by disrupting the function of the mammalian HOOK3 protein, a protein involved in the cellular traffic. (133 aa) | ||||
rne | RNase E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1067 aa) | ||||
flgD | Flagellar biosynthesis protein; Required for flagellar hook formation. May act as a scaffolding protein; Belongs to the FlgD family. (232 aa) | ||||
hpaC | 4-hydroxyphenylacetate catabolism protein; Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component or to other electron acceptors such as cytochrome c and Fe(3+) ion (By similarity); Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily. (170 aa) | ||||
kdpE | Response regulator in two-component regulatory system with KdpD; Regulates kdp operon encoding a high-affinity K translocating ATPase (OmpR family); similar to E. coli regulator of kdp operon (transcriptional effector) (AAC73788.1); Blastp hit to AAC73788.1 (225 aa), 91% identity in aa 1 - 224. (225 aa) | ||||
hha | Hemolysin expression modulating protein (involved in environmental regulation of virulence factors); Interacts with H-NS and in this complex might contact DNA, which could provide an additional surface for DNA binding to the H-NS- Hha complex; may not bind DNA in the absence of H-NS. In vitro improves the ability of H-NS to bind DNA under a precise set of conditions. (72 aa) | ||||
htrA | Periplasmic serine protease Do, heat shock protein; DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolyt [...] (475 aa) | ||||
leuO | Putative LysR family transcriptional regulator; Probable activator protein in leuabcd operon. (SW:LEUO_SALTY); Belongs to the LysR transcriptional regulatory family. (314 aa) | ||||
spaO | Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (303 aa) |