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prgK prgK nmpC nmpC avrA avrA sprB sprB hilC hilC prgJ prgJ prgI prgI prgH prgH hilD hilD iagB iagB sptP sptP sicP sicP iacP iacP sicA sicA spaS spaS spaQ spaQ spaP spaP spaO spaO invJ invJ invI invI invC invC invB invB invA invA invE invE invG invG invF invF invH invH mopA mopA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prgKCell invasion protein; Required for invasion of epithelial cells. Could be involved in protein secretion; Belongs to the YscJ lipoprotein family. (252 aa)
nmpCNew outer membrane protein; Forms pores that allow passive diffusion of small molecules across the outer membrane; Belongs to the Gram-negative porin family. (362 aa)
avrAPutative inner membrane protein. (302 aa)
sprBTranscriptional regulator SprB (gi|5007028). (251 aa)
hilCaraC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). (295 aa)
prgJCytoplasmic cell invasion protein; Required for invasion of epithelial cells. (101 aa)
prgICytoplasmic cell invasion protein; Required for invasion of epithelial cells; Belongs to the MxiH/PrgI/YscF family. (80 aa)
prgHCell invasion protein; Required for invasion of epithelial cells. (392 aa)
hilDRegulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). (309 aa)
iagBInvasion protein IAGB precursor. (SW:IAGB_SALTY); Belongs to the IagB/IpgF/P19 family. (160 aa)
sptPProtein tyrosine phosphate; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear. In the N-terminal section; belongs to the YopE family. (543 aa)
sicPChaparone related to virulence; Molecular chaperone required for SptP stabilization and secretion. (130 aa)
iacPPutative acyl carrier protein; Acyl carrier protein. (82 aa)
sicASurface presentation of antigens; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. (165 aa)
spaSSurface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the type III secretion exporter family. (356 aa)
spaQSurface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the FliQ/MopD/SpaQ family. (86 aa)
spaPSurface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (224 aa)
spaOSurface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (303 aa)
invJSurface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the SpaN family. (336 aa)
invISurface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. (147 aa)
invCSurface presentation of antigens; Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells. (431 aa)
invBSurface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion- competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA; Belongs to the SpaK family. (135 aa)
invAInvasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (685 aa)
invEInvasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA. Positively regulates the secretion of SPI-1 TTSS effector proteins SipB, SipC and SipD and negatively influences the secretion of [...] (372 aa)
invGOuter membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. (562 aa)
invFInvasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE. (216 aa)
invHInvasion protein; Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Pilot protein that is required for the proper localization of the secretin InvG/SctC in the outer membrane. Required for the secretion of the Sip virulence factors. (147 aa)
mopAChaperone Hsp60 with peptide-dependent ATPase activity; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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