node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ackA | gldA | STM2337 | STM4108 | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | Similar to E. coli glycerol dehydrogenase, (NAD) (AAC76927.1); Blastp hit to AAC76927.1 (380 aa), 91% identity in aa 14 - 380. | 0.468 |
ackA | ldhA | STM2337 | STM1647 | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | Similar to E. coli fermentative D-lactate dehydrogenase, NAD-dependent (AAC74462.1); Blastp hit to AAC74462.1 (329 aa), 94% identity in aa 1 - 328; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.621 |
ackA | pta | STM2337 | STM2338 | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | Phosphotransacetylase; Involved in acetate metabolism. Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate. The direction of the overall reaction changes depending on growth conditions. Required for acetate recapture but not for acetate excretion when this organism is grown on ethanolamine; In the N-terminal section; belongs to the CobB/CobQ family. | 0.999 |
btuR | cbiP | STM1718 | STM2019 | cob(I)alamin and cobinamide adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids; Belongs to the Cob(I)alamin adenosyltransferase family. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. | 0.997 |
btuR | cobD | STM1718 | STM0644 | cob(I)alamin and cobinamide adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids; Belongs to the Cob(I)alamin adenosyltransferase family. | Putative aminotransferase in cobalamin synthesis; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. | 0.432 |
btuR | hemC | STM1718 | STM3938 | cob(I)alamin and cobinamide adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids; Belongs to the Cob(I)alamin adenosyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.533 |
cbiM | cbiN | STM2023 | STM2022 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiN family. | 0.999 |
cbiM | cbiO | STM2023 | STM2020 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. Presumably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family. | 0.999 |
cbiM | cbiP | STM2023 | STM2019 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. | 0.902 |
cbiM | cboQ | STM2023 | STM2021 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiQ family. | 0.999 |
cbiM | hemB | STM2023 | STM0372 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Similar to E. coli 5-aminolevulinate dehydratase = porphobilinogen synthase (AAC73472.1); Blastp hit to AAC73472.1 (335 aa), 93% identity in aa 12 - 335; Belongs to the ALAD family. | 0.581 |
cbiM | hemC | STM2023 | STM3938 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.648 |
cbiM | hemD | STM2023 | STM3937 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. Belongs to the uroporphyrinogen-III synthase family. | 0.436 |
cbiM | malE | STM2023 | STM4229 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Maltose transport protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. | 0.540 |
cbiM | pduX | STM2023 | STM2058 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | Propanediol utilization protein; L-threonine kinase that catalyzes the conversion of L- threonine to L-threonine-O-3-phosphate. Involved in the de novo synthesis of adenosylcobalamin (coenzyme B12) and the assimilation of cobyric acid. Uses ATP; the activity with CTP, GTP or UTP is 6, 11, and 3% of the activity with ATP, respectively. | 0.479 |
cbiN | cbiM | STM2022 | STM2023 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiN family. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. | 0.999 |
cbiN | cbiO | STM2022 | STM2020 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiN family. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. Presumably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family. | 0.999 |
cbiN | cbiP | STM2022 | STM2019 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiN family. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. | 0.961 |
cbiN | cboQ | STM2022 | STM2021 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiN family. | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiQ family. | 0.999 |
cbiN | cobD | STM2022 | STM0644 | Synthesis of vitamin B12 adenosyl cobalamide precursor; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiN family. | Putative aminotransferase in cobalamin synthesis; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. | 0.404 |