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basR basR phoB phoB fes fes entF entF fepE fepE fepC fepC fepG fepG fepD fepD ybdA ybdA fepB fepB entC entC entE entE entB entB entA entA STM0718 STM0718 galM galM galK galK galT galT galE galE phoQ phoQ phoP phoP tonB tonB galU galU rcsA rcsA wzzB wzzB rfbN rfbN yeiP yeiP yojN yojN rcsB rcsB iroD iroD exbD exbD exbB exbB tolC tolC rfaL rfaL rfaJ rfaJ rfaB rfaB rfaP rfaP rfe rfe rffH rffH wzxE wzxE wecF wecF soxS soxS soxR soxR efp efp yjeA yjeA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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basRResponse regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. (222 aa)
phoBRegulates pho regulon (OmpR family); similar to E. coli positive response regulator for pho regulon, sensor is PhoR (or CreC) (AAC73502.1); Blastp hit to AAC73502.1 (229 aa), 95% identity in aa 1 - 229. (229 aa)
fesSimilar to E. coli enterochelin esterase (AAC73686.1); Blastp hit to AAC73686.1 (374 aa), 74% identity in aa 2 - 369. (404 aa)
entFEnterobactin synthetase, component F (nonribosomal peptide synthetase); Similar to E. coli ATP-dependent serine activating enzyme (may be part of enterobactin synthase as component F) (AAC73687.1); Blastp hit to AAC73687.1 (1293 aa), 79% identity in aa 1 - 1293. (1294 aa)
fepESimilar to E. coli ferric enterobactin (enterochelin) transport (AAC73688.1); Blastp hit to AAC73688.1 (377 aa), 73% identity in aa 1 - 373. (378 aa)
fepCEnterobactin transporter; ABC superfamily (atp_bind); similar to E. coli ATP-binding component of ferric enterobactin transport (AAC73689.1); Blastp hit to AAC73689.1 (271 aa), 92% identity in aa 1 - 263. (264 aa)
fepGFerric enterobactin transporter; ABC superfamily (membrane); similar to E. coli ferric enterobactin transport protein (AAC73690.1); Blastp hit to AAC73690.1 (330 aa), 86% identity in aa 2 - 330; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (329 aa)
fepDABC superfamily (membrane); similar to E. coli ferric enterobactin (enterochelin) transport (AAC73691.1); Blastp hit to AAC73691.1 (334 aa), 88% identity in aa 1 - 333; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (335 aa)
ybdAPutative POT family transport protein; Component of an export pathway for enterobactin. Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family. (414 aa)
fepBABC superfamily (peri_perm); similar to E. coli ferric enterobactin (enterochelin) binding protein; periplasmic component (AAC73693.1); Blastp hit to AAC73693.1 (318 aa), 79% identity in aa 1 - 318. (318 aa)
entCSimilar to E. coli isochorismate hydroxymutase 2, enterochelin biosynthesis (AAC73694.1); Blastp hit to AAC73694.1 (391 aa), 84% identity in aa 1 - 391. (391 aa)
entESimilar to E. coli 2,3-dihydroxybenzoate-AMP ligase (AAC73695.1); Blastp hit to AAC73695.1 (536 aa), 86% identity in aa 1 - 534. (536 aa)
entBSimilar to E. coli 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase (AAC73696.1); Blastp hit to AAC73696.1 (285 aa), 88% identity in aa 1 - 285. (285 aa)
entASimilar to E. coli 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis (AAC73697.1); Blastp hit to AAC73697.1 (248 aa), 90% identity in aa 2 - 248. (251 aa)
STM0718Putative cytoplasmic protein. (246 aa)
galMGalactose-1-epimerase (mutarotase); Converts alpha-aldose to the beta-anomer. (346 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (382 aa)
galTGalactose-1-phosphate uridylyltransferase. (SW:GAL7_SALTY). (348 aa)
galEUDP-galactose 4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity). (338 aa)
phoQSensory kinase protein in two-component regulatory system with PhoP; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane- associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of [...] (487 aa)
phoPResponse regulator in two-component regulatory system with PhoQ; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repressio [...] (224 aa)
tonBTonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific en [...] (242 aa)
galUSimilar to E. coli glucose-1-phosphate uridylyltransferase (AAC74318.1); Blastp hit to AAC74318.1 (302 aa), 97% identity in aa 1 - 302. (302 aa)
rcsAPositive transcriptional regulator of capsular/exo- polysaccharide synthesis (LuxR/UhpA family); Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes. (207 aa)
wzzBRegulator of length of O-antigen component of lipopolysaccharide chains; Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 20; Belongs to the WzzB/Cld/Rol family. (327 aa)
rfbNLPS side chain defect: putative rhamnosyltransferase RFBN. (SW:RFBN_SALTY). (314 aa)
yeiPSimilar to E. coli putative elongation factor (AAC75232.1); Blastp hit to AAC75232.1 (275 aa), 83% identity in aa 8 - 275. (267 aa)
yojNPutative sensor/kinase in regulatory system; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (889 aa)
rcsBLuxR/UhpA family response regulator in two-component regulatory system with RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa)
iroDEnterochelin esterase-like protein (Fes); Similar to E. coli enterochelin esterase (AAC73686.1); Blastp hit to AAC73686.1 (374 aa), 31% identity in aa 3 - 362. (414 aa)
exbDtonB-dependent uptake of B colicins; similar to E. coli uptake of enterochelin; tonB-dependent uptake of B colicins (AAC76041.1); Blastp hit to AAC76041.1 (141 aa), 93% identity in aa 1 - 141. (141 aa)
exbBUptake of enterochelin; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity). (244 aa)
tolCOuter membrane channel; Specific tolerance to colicin E1; segregation of daughter chromosomes; role in organic solvent tolerance; similar to E. coli outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (AAC76071.1); Blastp hit to AAC76071.1 (495 aa), 89% identity in aa 1 - 495. (491 aa)
rfaLO-antigen ligase; Adds the O-antigen on the glucose(II) group of LPS. (404 aa)
rfaJUDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase; Adds the glucose(II) group on the galactose(I) group of LPS. (336 aa)
rfaBUDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Adds a galactose goup to a glucose group of LPS; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (359 aa)
rfaPLipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. (265 aa)
rfeUndecaprenyl-phosphate N-acetylglucosaminyltransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily. (367 aa)
rffHSimilar to E. coli glucose-1-phosphate thymidylyltransferase (AAC76794.1); Blastp hit to AAC76794.1 (293 aa), 95% identity in aa 240 - 24. (74 aa)
wzxEO-antigen translocase in LPS biosyntesis; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa)
wecFTDP-Fuc4NAc:lipidII transferase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (452 aa)
soxSTranscriptional activator of superoxide response regulon; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity). (107 aa)
soxRRedox-sensing transcriptional activator SoxR; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity). (152 aa)
efpElongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation. (188 aa)
yjeAPutative pyruvate oxidase; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta- lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF- P 'Lys-34' (Probable). Can also use L-alpha-lysine as a substrate, but probably with lower efficiency. Cannot aminoacylate tRNA(Lys) with lysine. (325 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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