STRINGSTRING
folE folE ptsA ptsA dapF dapF trxA trxA dnaN dnaN cspA cspA uspA uspA asd asd folP folP folB folB lysA lysA trxC trxC dapA dapA ptsI ptsI ptsH ptsH dapB dapB folA folA folK folK cspE cspE cspD cspD cspH cspH pheT pheT pspC pspC pspB pspB pspA pspA pspF pspF cspC cspC cspB cspB wcaB wcaB lysC lysC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
folESimilar to E. coli GTP cyclohydrolase I (AAC75214.1); Blastp hit to AAC75214.1 (222 aa), 96% identity in aa 1 - 221. (222 aa)
ptsAGeneral PTS family enzyme I; Similar to E. coli PEP-protein phosphotransferase system enzyme I (AAC76929.1); Blastp hit to AAC76929.1 (711 aa), 90% identity in aa 1 - 711. (833 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa)
trxAThioredoxin 1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions; Belongs to the thioredoxin family. (109 aa)
dnaNDNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa)
cspAMajor cold shock protein 7.4; Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3' (By similarity). (70 aa)
uspAUniversal stress protein A; Required for resistance to DNA-damaging agents. (144 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
folP7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
trxCSimilar to E. coli putative thioredoxin-like protein (AAC75635.1); Blastp hit to AAC75635.1 (139 aa), 94% identity in aa 1 - 139; Belongs to the thioredoxin family. (139 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
ptsIPEP-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa)
ptsHPhosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (85 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
folADihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa)
folK7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, PPPK; Similar to E. coli 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase (AAC73253.1); Blastp hit to AAC73253.1 (159 aa), 87% identity in aa 1 - 148. (159 aa)
cspERNA chaperone, negative regulator of cspA transcription; Similar to E. coli cold shock protein (AAC73724.1); Blastp hit to AAC73724.1 (69 aa), 98% identity in aa 1 - 69. (69 aa)
cspDCspA-like protein but not cold shock induced; Similar to E. coli cold shock protein (AAC73967.1); Blastp hit to AAC73967.1 (74 aa), 94% identity in aa 1 - 71. (73 aa)
cspHHomology with cold shock proteins; Cold shock-like protein CSPH. (SW:CSPH_SALTY). (70 aa)
pheTPhenylalanine tRNA synthetase, beta-subunit; phenylalanyl-tRNA synthetase beta chain. (SW:SYFB_SALTY); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (795 aa)
pspCPhage shock protein; Regulatory gene; activates expression of psp operon with PspB; similar to E. coli phage shock protein: activates phage shock-protein expression (AAC74388.1); Blastp hit to AAC74388.1 (119 aa), 84% identity in aa 1 - 119. (119 aa)
pspBPhage shock protein; Regulatory gene; activates expression of psp operon with PspC; similar to E. coli phage shock protein (AAC74387.1); Blastp hit to AAC74387.1 (74 aa), 89% identity in aa 1 - 74. (74 aa)
pspAPhage shock protein; Negative regulatory gene for the psp opreon; similar to E. coli phage shock protein, inner membrane protein (AAC74386.1); Blastp hit to AAC74386.1 (222 aa), 91% identity in aa 1 - 222. (222 aa)
pspFSimilar to E. coli psp operon transcriptional activator (AAC74385.1); Blastp hit to AAC74385.1 (330 aa), 86% identity in aa 6 - 330. (326 aa)
cspCCold shock protein; Multicopy suppresses mukB mutants, putative regulator; cold shock-like protein CSPC. (SW:CSPC_SALTY). (69 aa)
cspBPutative cold-shock protein; Similar to E. coli cold shock-like protein (AAC74625.1); Blastp hit to AAC74625.1 (70 aa), 84% identity in aa 1 - 70. (70 aa)
wcaBPutative acyl transferase; In colanic acid gene cluster; similar to E. coli putative transferase (AAC75119.1); Blastp hit to AAC75119.1 (162 aa), 91% identity in aa 1 - 160; Belongs to the transferase hexapeptide repeat family. (162 aa)
lysCSimilar to E. coli aspartokinase III, lysine sensitive (AAC76994.1); Blastp hit to AAC76994.1 (449 aa), 93% identity in aa 1 - 449; Belongs to the aspartokinase family. (449 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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