STRINGSTRING
bcr bcr mdtA mdtA ydgF ydgF ydhE ydhE phoP phoP yceE yceE mdfA mdfA fsr fsr acrA acrA polB polB yjiO yjiO yidY yidY emrD emrD emrA emrA acrF acrF acrD acrD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bcrBicyclomycin resistance protein; MFS family multidrug transport protein; similar to E. coli bicyclomycin resistance protein; transmembrane protein (AAC75243.1); Blastp hit to AAC75243.1 (396 aa), 93% identity in aa 1 - 396. (396 aa)
mdtAPutative HlyD family secretion protein; Similar to E. coli putative membrane protein (AAC75135.1); Blastp hit to AAC75135.1 (464 aa), 82% identity in aa 50 - 464; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (413 aa)
ydgFPutative membrane transporter of cations and cationic drugs; Catalyzes the excretion of spermidine. (120 aa)
ydhEPutative MATE family transport protein; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. (457 aa)
phoPResponse regulator in two-component regulatory system with PhoQ; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repressio [...] (224 aa)
yceESimilar to E. coli putative transport protein (AAC74137.1); Blastp hit to AAC74137.1 (408 aa), 27% identity in aa 1 - 404. (404 aa)
mdfAMultidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406. (410 aa)
fsrPutative MFS family of transport protein; Similar to E. coli fosmidomycin resistance protein (AAC73581.1); Blastp hit to AAC73581.1 (406 aa), 93% identity in aa 1 - 405. (406 aa)
acrASimilar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 91% identity in aa 1 - 397; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (397 aa)
polBDNA polymerase II; 3'->5' exonuclease; similar to E. coli DNA polymerase II (AAC73171.1); Blastp hit to AAC73171.1 (783 aa), 89% identity in aa 1 - 783. (783 aa)
yjiOSimilar to E. coli putative transport protein (AAC77293.1); Blastp hit to AAC77293.1 (410 aa), 86% identity in aa 3 - 410. (413 aa)
yidYPutative MFS family tranport protein; 1st mdule; similar to E. coli putative transport protein (AAC76733.1); Blastp hit to AAC76733.1 (391 aa), 77% identity in aa 1 - 391. (395 aa)
emrDMFS family multidrug tranport protein; Similar to E. coli 2-module integral membrane pump; multidrug resistance (AAC76696.1); Blastp hit to AAC76696.1 (396 aa), 92% identity in aa 3 - 396. (394 aa)
emrASimilar to E. coli multidrug resistance secretion protein (AAC75732.1); Blastp hit to AAC75732.1 (390 aa), 89% identity in aa 1 - 390. (390 aa)
acrFRND family multidrug transport protein; Similar to E. coli integral transmembrane protein; acridine resistance (AAC76298.1); Blastp hit to AAC76298.1 (1034 aa), 22% identity in aa 1 - 506; acriflavin resistance protein F. (1037 aa)
acrDRND family aminoglycoside/multidrug efflux pump; Similar to E. coli sensitivity to acriflavine, integral membrane protein, possible efflux pump (AAC75523.1); Blastp hit to AAC75523.1 (1037 aa), 94% identity in aa 1 - 1037. (1037 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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