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pduL pduL pduF pduF pduH pduH pduE pduE cbiA cbiA pocR pocR pduC pduC eutP eutP ackA ackA gyrA gyrA pduW pduW pduV pduV pduT pduT pduQ pduQ pduP pduP pduN pduN pduM pduM pduJ pduJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pduLPropanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. Is also able to catalyze the reverse reaction. To a lesser extent, also displays phosphate acetyltransferase activity. Belongs to the PduL family. (210 aa)
pduFPropanediol utilization protein; May facilitate the diffusion of propanediol; Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
pduHPropanediol utilization diol dehydratase reactivation protein. (116 aa)
pduEPropanediol utilization dehydratase, small subunit; Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol to propionaldehyde. Is required for S.typhimurium growth on 1,2-propanediol as the sole carbon and energy source; Belongs to the diol/glycerol dehydratase small subunit family. (173 aa)
cbiASynthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Is able to use other nucleotide triphosphates as substrate, such as GTP or UTP, although less efficiently than ATP; Belongs to the CobB/CbiA family. (459 aa)
pocRPropanediol utilization protein; Positive regulatory protein of pdu and cob operons. (303 aa)
pduCPropanediol utilization dehydratase, large subunit; Part of the PduCDE complex that catalyzes the dehydration of 1,2-propanediol to propionaldehyde. Is required for S.typhimurium growth on 1,2-propanediol as the sole carbon and energy source. (554 aa)
eutPEthanolamine utilization protein EUTP. (SW:EUTP_SALTY). (159 aa)
ackAAcetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. (400 aa)
gyrADNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...] (878 aa)
pduWProbable propionate kinase. (SW:PDUW_SALTY); Belongs to the acetokinase family. PduW subfamily. (404 aa)
pduVPropanediol utilization protein PDUV. (SW:PDUV_SALTY). (150 aa)
pduTPropanediol utilization protein; Polyhedral bodies; similar to E. coli detox protein (AAC75510.1); Blastp hit to AAC75510.1 (111 aa), 41% identity in aa 16 - 93, 31% identity in aa 16 - 90. (184 aa)
pduQPropanediol utilization propanol dehydrogenase; Similar to E. coli CoA-linked acetaldehyde dehydrogenase and iron-dependent alcohol dehydrogenase; pyruvate-formate-lyase deactivase (AAC74323.1); Blastp hit to AAC74323.1 (891 aa), 40% identity in aa 574 - 860, 35% identity in aa 456 - 556. (370 aa)
pduPPropanediol utilization CoA-dependent propionaldehyde dehydrogenase; Similar to E. coli ethanolamine utilization; similar to acetaldehyde dehydrogenase (AAC75508.1); Blastp hit to AAC75508.1 (467 aa), 45% identity in aa 1 - 466. (464 aa)
pduNPropanediol utilization protein; Polyhedral bodies; similar to E. coli detox protein (AAC75509.1); Blastp hit to AAC75509.1 (95 aa), 43% identity in aa 1 - 83. (91 aa)
pduMPropanediol utilization protein. (163 aa)
pduJPropanediol utilization protein; Polyhedral bodies; similar to E. coli detox protein (AAC75510.1); Blastp hit to AAC75510.1 (111 aa), 64% identity in aa 17 - 101. (91 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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