node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dnaK | fliC | STM0012 | STM1959 | Chaperone Hsp70; Acts as a chaperone. | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | 0.847 |
dnaK | fljB | STM0012 | STM2771 | Chaperone Hsp70; Acts as a chaperone. | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | 0.825 |
fliC | dnaK | STM1959 | STM0012 | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Chaperone Hsp70; Acts as a chaperone. | 0.847 |
fliC | fljB | STM1959 | STM2771 | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | 0.989 |
fliC | invA | STM1959 | STM2896 | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | 0.935 |
fliC | prgI | STM1959 | STM2873 | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells; Belongs to the MxiH/PrgI/YscF family. | 0.832 |
fliC | prgJ | STM1959 | STM2872 | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | 0.973 |
fliC | sipA | STM1959 | STM2882 | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cell invasion protein; Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments; [...] | 0.891 |
fliC | sipC | STM1959 | STM2884 | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cell invasion protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell. | 0.839 |
fliC | sipD | STM1959 | STM2883 | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cell invasion protein; Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC. | 0.683 |
fljB | dnaK | STM2771 | STM0012 | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Chaperone Hsp70; Acts as a chaperone. | 0.825 |
fljB | fliC | STM2771 | STM1959 | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | 0.989 |
fljB | invA | STM2771 | STM2896 | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | 0.897 |
fljB | prgI | STM2771 | STM2873 | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells; Belongs to the MxiH/PrgI/YscF family. | 0.804 |
fljB | prgJ | STM2771 | STM2872 | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells. | 0.961 |
fljB | sipA | STM2771 | STM2882 | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cell invasion protein; Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments; [...] | 0.807 |
fljB | sipC | STM2771 | STM2884 | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cell invasion protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell. | 0.712 |
fljB | sipD | STM2771 | STM2883 | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | Cell invasion protein; Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC. | 0.520 |
invA | fliC | STM2896 | STM1959 | Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | 0.935 |
invA | fljB | STM2896 | STM2771 | Invasion protein; Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Filament structural protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | 0.897 |