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yihR yihR allR allR deoR deoR pfkB pfkB purR purR tyrR tyrR cysB cysB ygbL ygbL gcvA gcvA fba fba lyxK lyxK STM3781 STM3781 yshA yshA yihO yihO yihQ yihQ yihS yihS yihT yihT yihU yihU yihV yihV glpX glpX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yihRSimilar to E. coli putative aldose-1-epimerase (AAC76876.1); Blastp hit to AAC76876.1 (308 aa), 54% identity in aa 9 - 303. (285 aa)
allRPutative regulatory protein; Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region (By similarity). (272 aa)
deoRSimilar to E. coli transcriptional repressor for deo operon, tsx, nupG (AAC73927.1); Blastp hit to AAC73927.1 (252 aa), 83% identity in aa 1 - 252. (252 aa)
pfkBSimilar to E. coli 6-phosphofructokinase II; suppressor of pfkA (AAC74793.1); Blastp hit to AAC74793.1 (309 aa), 92% identity in aa 1 - 308; Belongs to the carbohydrate kinase PfkB family. (310 aa)
purRTranscriptional repressor for pur regulon, glyA, glnB, prsA, speA (GalR/LacI family); Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa)
tyrRTranscriptional regulatory protein TyrR; Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalani [...] (513 aa)
cysBTranscriptional regulator for cysteine regulon; This protein is a positive regulator of gene expression for the cysteine regulon, a system of 10 or more loci involved in the biosynthesis of L-cysteine from inorganic sulfate. The inducer for CysB is N-acetylserine. CysB inhibits its own transcription. (324 aa)
ygbLSimilar to E. coli putative epimerase/aldolase (AAC75780.1); Blastp hit to AAC75780.1 (212 aa), 85% identity in aa 1 - 211. (212 aa)
gcvARegulator of gcv operon; LysR family; similar to E. coli positive regulator of gcv operon (AAC75850.1); Blastp hit to AAC75850.1 (305 aa), 98% identity in aa 1 - 305; Belongs to the LysR transcriptional regulatory family. (305 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
lyxKSimilar to E. coli L-xylulose kinase, cryptic (AAC76604.1); Blastp hit to AAC76604.1 (498 aa), 85% identity in aa 1 - 498. (498 aa)
STM3781Putative sugar (pentulose and hexulose) kinase; Similar to E. coli L-fuculokinase (AAC75845.1); Blastp hit to AAC75845.1 (482 aa), 24% identity in aa 17 - 444. (494 aa)
yshAPutative outer membrane protein; Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is unknown (By similarity); Belongs to the oligogalacturonate-specific porin KdgM (TC 1.B.35) family. OmpL subfamily. (230 aa)
yihOPutative GPH family transport protein; Could be involved in sulfoquinovose import; Belongs to the sodium:galactoside symporter (TC 2.A.2) family. (473 aa)
yihQSimilar to E. coli putative glycosidase (AAC76875.1); Blastp hit to AAC76875.1 (678 aa), 88% identity in aa 10 - 678; Belongs to the glycosyl hydrolase 31 family. (678 aa)
yihSPutative isomerase; Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF) (By similarity). In vitro, can also catalyze the interconversion of mannose, fructose and glucose, but has extremely low activity with glucose. Belongs to the N-acylglucosamine 2-epimerase family. (413 aa)
yihTPutative aldolase; Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). Belongs to the aldolase LacD family. (292 aa)
yihUPutative oxidoreductase; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (298 aa)
yihVPutative sugar kinase; Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6-deoxy-6- sulfo-D-fructose 1-phosphate (SFP); Belongs to the carbohydrate kinase PfkB family. (298 aa)
glpXSimilar to E. coli unknown function in glycerol metabolism (AAC76907.1); Blastp hit to AAC76907.1 (336 aa), 94% identity in aa 1 - 336. (336 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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