Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hilC | hilD | STM2867 | STM2875 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | 0.692 |
| hilC | invG | STM2867 | STM2898 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Outer membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. | 0.599 |
| hilC | prgH | STM2867 | STM2874 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Cell invasion protein; Required for invasion of epithelial cells. | 0.936 |
| hilC | prgI | STM2867 | STM2873 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells; Belongs to the MxiH/PrgI/YscF family. | 0.779 |
| hilC | prgK | STM2867 | STM2871 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Cell invasion protein; Required for invasion of epithelial cells. Could be involved in protein secretion; Belongs to the YscJ lipoprotein family. | 0.641 |
| hilC | sipA | STM2867 | STM2882 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Cell invasion protein; Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments; [...] | 0.844 |
| hilC | sipB | STM2867 | STM2885 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Cell invasion protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chape [...] | 0.852 |
| hilC | sipC | STM2867 | STM2884 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Cell invasion protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell. | 0.859 |
| hilC | sopB | STM2867 | STM1091 | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | Pathogenicity island encoded protein: SPI5; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulti [...] | 0.820 |
| hilD | hilC | STM2875 | STM2867 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | 0.692 |
| hilD | invG | STM2875 | STM2898 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | Outer membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. | 0.635 |
| hilD | prgH | STM2875 | STM2874 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | Cell invasion protein; Required for invasion of epithelial cells. | 0.978 |
| hilD | prgI | STM2875 | STM2873 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | Cytoplasmic cell invasion protein; Required for invasion of epithelial cells; Belongs to the MxiH/PrgI/YscF family. | 0.885 |
| hilD | prgK | STM2875 | STM2871 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | Cell invasion protein; Required for invasion of epithelial cells. Could be involved in protein secretion; Belongs to the YscJ lipoprotein family. | 0.786 |
| hilD | sipA | STM2875 | STM2882 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | Cell invasion protein; Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments; [...] | 0.927 |
| hilD | sipB | STM2875 | STM2885 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | Cell invasion protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chape [...] | 0.920 |
| hilD | sipC | STM2875 | STM2884 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | Cell invasion protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell. | 0.930 |
| hilD | sopB | STM2875 | STM1091 | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | Pathogenicity island encoded protein: SPI5; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulti [...] | 0.856 |
| invG | hilC | STM2898 | STM2867 | Outer membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. | araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1). | 0.599 |
| invG | hilD | STM2898 | STM2875 | Outer membrane invasion protein; Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane. | Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108). | 0.635 |
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