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pheA pheA pyrC pyrC purA purA atpI atpI uhpT uhpT pyrE pyrE dut dut gcvT gcvT purE purE purB purB purG purG purM purM purC purC prfA prfA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pheAChorismate mutase P; Bifuctional; similar to E. coli chorismate mutase-P and prephenate dehydratase (AAC75648.1); Blastp hit to AAC75648.1 (386 aa), 90% identity in aa 1 - 385. (386 aa)
pyrCDihydro-orotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
atpISimilar to E. coli membrane-bound ATP synthase, dispensable protein, affects expression of atpB (AAC76762.1); Blastp hit to AAC76762.1 (130 aa), 91% identity in aa 5 - 130. (126 aa)
uhpTMFS family hexose phosphate transport protein; Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. (463 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
dutDeoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa)
gcvTGlycine cleavage complex protein T; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
purEPhosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
purBSimilar to E. coli adenylosuccinate lyase (AAC74215.1); Blastp hit to AAC74215.1 (456 aa), 94% identity in aa 1 - 456. (456 aa)
purGPhosphoribosylformylglycinamidine synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
purMAIR synthetase; similar to E. coli phosphoribosylaminoimidazole synthetase = AIR synthetase (AAC75552.1); Blastp hit to AAC75552.1 (345 aa), 91% identity in aa 1 - 345. (345 aa)
purCSAICAR synthetase; similar to E. coli phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase (AAC75529.1); Blastp hit to AAC75529.1 (237 aa), 94% identity in aa 1 - 237. (237 aa)
prfAPeptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (360 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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