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hemG hemG lpxA lpxA hemL hemL ppdD ppdD lpxC lpxC hemN hemN hemD hemD hemY hemY exbD exbD hemA hemA kdsA kdsA galU galU ompA ompA galE galE hemH hemH hemB hemB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hemGProtoporphyrin oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor. (181 aa)
lpxAUDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (SW:GSA_SALTY). (426 aa)
ppdDPrelipin peptidase dependent protein; Putative major component of type IV pilin; similar to E. coli prelipin peptidase dependent protein (AAC73219.1); Blastp hit to AAC73219.1 (146 aa), 89% identity in aa 1 - 146. (145 aa)
lpxCUDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
hemNO2-independent coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX. (457 aa)
hemDUroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. Belongs to the uroporphyrinogen-III synthase family. (246 aa)
hemYSimilar to E. coli a late step of protoheme IX synthesis (AAC76805.1); Blastp hit to AAC76805.1 (398 aa), 95% identity in aa 1 - 398. (399 aa)
exbDtonB-dependent uptake of B colicins; similar to E. coli uptake of enterochelin; tonB-dependent uptake of B colicins (AAC76041.1); Blastp hit to AAC76041.1 (141 aa), 93% identity in aa 1 - 141. (141 aa)
hemAGlutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (418 aa)
kdsA3-deoxy-D-manno-octulosonic acid 8-P synthetase; Similar to E. coli 2-dehydro-3-deoxyphosphooctulonate aldolase (AAC74299.1); Blastp hit to AAC74299.1 (284 aa), 93% identity in aa 1 - 282; Belongs to the KdsA family. (284 aa)
galUSimilar to E. coli glucose-1-phosphate uridylyltransferase (AAC74318.1); Blastp hit to AAC74318.1 (302 aa), 97% identity in aa 1 - 302. (302 aa)
ompAPutative membrane component hydrogenase; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage. (350 aa)
galEUDP-galactose 4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity). (338 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (320 aa)
hemBSimilar to E. coli 5-aminolevulinate dehydratase = porphobilinogen synthase (AAC73472.1); Blastp hit to AAC73472.1 (335 aa), 93% identity in aa 12 - 335; Belongs to the ALAD family. (324 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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