STRINGSTRING
bacA bacA ksgA ksgA acrA acrA kdpE kdpE mdfA mdfA msbA msbA ssaB ssaB marR marR galU galU rfbP rfbP wzc wzc baeR baeR glpT glpT pmrF pmrF emrR emrR emrB emrB crp crp rfaF rfaF rfaC rfaC rfaL rfaL rfaY rfaY rfaJ rfaJ rfaI rfaI rfaB rfaB rfaP rfaP rfaH rfaH aceA aceA yjeJ yjeJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bacABacitracin resistance; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa)
ksgAS-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (273 aa)
acrASimilar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 91% identity in aa 1 - 397; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (397 aa)
kdpEResponse regulator in two-component regulatory system with KdpD; Regulates kdp operon encoding a high-affinity K translocating ATPase (OmpR family); similar to E. coli regulator of kdp operon (transcriptional effector) (AAC73788.1); Blastp hit to AAC73788.1 (225 aa), 91% identity in aa 1 - 224. (225 aa)
mdfAMultidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406. (410 aa)
msbAMulticopy repressor of htrB transport protein; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. (582 aa)
ssaBSecretion system apparatus protein; Virulence protein that plays a central role in mammalian macrophage infection, by inhibiting phagosome-lysosome fusion and cellular trafficking. May act by disrupting the function of the mammalian HOOK3 protein, a protein involved in the cellular traffic. (133 aa)
marRTranscriptional repressor of marRAB operon; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. (144 aa)
galUSimilar to E. coli glucose-1-phosphate uridylyltransferase (AAC74318.1); Blastp hit to AAC74318.1 (302 aa), 97% identity in aa 1 - 302. (302 aa)
rfbPUndecaprenol-phosphate galactosephosphotransferase, and; Is responsible for transferring galactose-1-phosphate to the lipid precursor undecaprenol phosphate in the first steps of O- polysaccharide biosynthesis; Belongs to the bacterial sugar transferase family. (476 aa)
wzcPutative tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium (By similarity). Belongs to the etk/wzc family. (719 aa)
baeROmpR family; similar to E. coli transcriptional response regulatory protein (sensor BaeS) (AAC75140.1); Blastp hit to AAC75140.1 (240 aa), 96% identity in aa 1 - 240. (240 aa)
glpTMFS family, sn-glycerol-3-phosphate transport protein; Similar to E. coli sn-glycerol-3-phosphate permease (AAC75300.1); Blastp hit to AAC75300.1 (452 aa), 96% identity in aa 1 - 452. (452 aa)
pmrFPutative glycosyl transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Plays an important role in pathogenesis by providing resistance to antimicrobial peptides within macrophages or at other anatomic sites encountered during infection. Belongs to the glycosyltransferase 2 family. (327 aa)
emrRTranscriptional repressor of emrAB operon; MarR family; similar to E. coli regulator of plasmid mcrB operon (microcin B17 synthesis) (AAC75731.1); Blastp hit to AAC75731.1 (176 aa), 93% identity in aa 1 - 175. (176 aa)
emrBPutative MFS superfamily multidrug transport protein; Similar to E. coli multidrug resistance; probably membrane translocase (AAC75733.1); Blastp hit to AAC75733.1 (512 aa), 95% identity in aa 1 - 512; Belongs to the major facilitator superfamily. (512 aa)
crpCatabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). (210 aa)
rfaFADP-heptose; AFP-heptose--lps heptosyltransferase II. (SW:RFAF_SALTY). (348 aa)
rfaCHeptosyl transferase I; Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA; Belongs to the glycosyltransferase 9 family. (317 aa)
rfaLO-antigen ligase; Adds the O-antigen on the glucose(II) group of LPS. (404 aa)
rfaYLipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. RfaY/WaaY family. (232 aa)
rfaJUDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase; Adds the glucose(II) group on the galactose(I) group of LPS. (336 aa)
rfaIUDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase; Adds the galactose(I) group on the glucose(I) group of LPS. (337 aa)
rfaBUDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Adds a galactose goup to a glucose group of LPS; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (359 aa)
rfaPLipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. (265 aa)
rfaHTranscriptional activator; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. (162 aa)
aceAIsocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. (434 aa)
yjeJPutative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77105.1); Blastp hit to AAC77105.1 (289 aa), 58% identity in aa 1 - 283. (285 aa)
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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