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thrA | Bifunctional; N-terminaus is aspartokinase I and C terminus is homoserine dehydrogenase I; similar to E. coli aspartokinase I, homoserine dehydrogenase I (AAC73113.1); Blastp hit to AAC73113.1 (820 aa), 94% identity in aa 1 - 820; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa) | ||||
thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) | ||||
thrC | Similar to E. coli threonine synthase (AAC73115.1); Blastp hit to AAC73115.1 (428 aa), 93% identity in aa 1 - 428. (428 aa) | ||||
lpdA | Lipoamide dehydrogenase (NADH); Component of 2-oxodehydrogenase and pyruvate complexes; L protein of glycine cleavage complex second part; similar to E. coli lipoamide dehydrogenase (NADH); component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex (AAC73227.1); Blastp hit to AAC73227.1 (474 aa), 98% identity in aa 1 - 474. (474 aa) | ||||
glxK | Glycerate kinase II; Similar to E. coli orf, hypothetical protein (AAC73616.1); Blastp hit to AAC73616.1 (381 aa), 80% identity in aa 1 - 379; Belongs to the glycerate kinase type-1 family. (382 aa) | ||||
gpmA | Phosphoglyceromutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) | ||||
ltaA | L-allo-threonine aldolase; Similar to E. coli putative arylsulfatase (AAC73957.1); Blastp hit to AAC73957.1 (333 aa), 88% identity in aa 1 - 333. (333 aa) | ||||
serC | 3-phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) | ||||
ycdW | Putative oxidoreductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa) | ||||
ydfG | Putative oxidoreductase; NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L- allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation sin [...] (248 aa) | ||||
trpB | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpB family. (397 aa) | ||||
trpA | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. (268 aa) | ||||
sdaA | Similar to E. coli L-serine deaminase (AAC74884.1); Blastp hit to AAC74884.1 (454 aa), 94% identity in aa 1 - 454; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) | ||||
STM2196 | Putative D-serine dehydratase; Similar to E. coli L-serine deaminase (AAC74884.1); Blastp hit to AAC74884.1 (454 aa), 48% identity in aa 1 - 452; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) | ||||
glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). (417 aa) | ||||
pssA | Phosphatidylserine synthase; CDP-diacylglycerol-serine O-phosphatidyltransferase; similar to E. coli phosphatidylserine synthase; phospholipid synthesis (AAC75638.1); Blastp hit to AAC75638.1 (452 aa), 93% identity in aa 2 - 452. (451 aa) | ||||
STM2959 | Putative glycerate kinase 2; Similar to E. coli orf, hypothetical protein (AAC76158.1); Blastp hit to AAC76158.1 (408 aa), 68% identity in aa 28 - 405; Belongs to the glycerate kinase type-1 family. (380 aa) | ||||
sdaB | Similar to E. coli L-serine dehydratase (deaminase), L-SD2 (AAC75839.1); Blastp hit to AAC75839.1 (455 aa), 94% identity in aa 1 - 455; L-threonine deaminase 2; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) | ||||
gcvP | Glycine cleavage complex protein P; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa) | ||||
gcvH | Glycine cleavage complex protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) | ||||
gcvT | Glycine cleavage complex protein T; The glycine cleavage system catalyzes the degradation of glycine. (364 aa) | ||||
serA | Similar to E. coli D-3-phosphoglycerate dehydrogenase (AAC75950.1); Blastp hit to AAC75950.1 (410 aa), 96% identity in aa 1 - 410; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) | ||||
tdcG | Similar to E. coli L-serine dehydratase (deaminase), L-SD2 (AAC75839.1); Blastp hit to AAC75839.1 (455 aa), 74% identity in aa 1 - 452; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) | ||||
tdcB | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to yield pyruv [...] (329 aa) | ||||
garK | Glycerate kinase; Similar to E. coli orf, hypothetical protein (AAC76158.1); Blastp hit to AAC76158.1 (408 aa), 86% identity in aa 28 - 408; Belongs to the glycerate kinase type-1 family. (381 aa) | ||||
asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) | ||||
yiaE | 2-keto-D-gluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (324 aa) | ||||
pmgI | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) | ||||
tdh | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa) | ||||
kbl | 2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa) | ||||
dsdA | Similar to E. coli D-serine dehydratase (deaminase) (AAC75425.1); Blastp hit to AAC75425.1 (442 aa), 89% identity in aa 1 - 442. (440 aa) | ||||
ilvA | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/threon [...] (514 aa) | ||||
metL | Aspartokinase II; Bifunctional; similar to E. coli aspartokinase II and homoserine dehydrogenase II (AAC76922.1); Blastp hit to AAC76922.1 (810 aa), 94% identity in aa 1 - 810; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) | ||||
lysC | Similar to E. coli aspartokinase III, lysine sensitive (AAC76994.1); Blastp hit to AAC76994.1 (449 aa), 93% identity in aa 1 - 449; Belongs to the aspartokinase family. (449 aa) | ||||
serB | Similar to E. coli 3-phosphoserine phosphatase (AAC77341.1); Blastp hit to AAC77341.1 (322 aa), 93% identity in aa 1 - 322. (322 aa) | ||||
gpmB | Similar to E. coli phosphoglyceromutase 2 (AAC77348.1); Blastp hit to AAC77348.1 (215 aa), 91% identity in aa 1 - 215; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |