STRINGSTRING
aroQ aroQ aroE aroE B1806_01620 B1806_01620 ahcY ahcY B1806_02065 B1806_02065 ilvE ilvE B1806_13910 B1806_13910 B1806_07090 B1806_07090 trpE trpE B1806_14870 B1806_14870 trpD trpD trpC trpC B1806_05230 B1806_05230 metZ metZ B1806_10100 B1806_10100 B1806_10095 B1806_10095 B1806_03735 B1806_03735 B1806_14505 B1806_14505 B1806_02130 B1806_02130 B1806_10675 B1806_10675 B1806_08550 B1806_08550 dapA dapA B1806_01465 B1806_01465 serC serC GCA_002077135_02232 GCA_002077135_02232 aroA aroA trpA trpA trpB trpB trpF trpF asd asd aroC aroC dapB dapB hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD hisG hisG B1806_15885 B1806_15885 B1806_15875 B1806_15875 hisS hisS B1806_08280 B1806_08280 thrB thrB B1806_08270 B1806_08270 cysS cysS B1806_14120 B1806_14120 B1806_02805 B1806_02805 aroK aroK aroB aroB dapE dapE B1806_12860 B1806_12860 metK metK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aroQUnannotated protein; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa)
aroEUnannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (279 aa)
B1806_01620Unannotated protein. (328 aa)
ahcYUnannotated protein; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (476 aa)
B1806_02065Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
ilvEUnannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
B1806_13910Unannotated protein. (377 aa)
B1806_07090Unannotated protein. (374 aa)
trpEUnannotated protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (491 aa)
B1806_14870Unannotated protein. (192 aa)
trpDUnannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa)
trpCUnannotated protein; Belongs to the TrpC family. (266 aa)
B1806_05230Unannotated protein; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (628 aa)
metZUnannotated protein; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (413 aa)
B1806_10100Unannotated protein; Belongs to the AB hydrolase superfamily. MetX family. (343 aa)
B1806_10095Unannotated protein. (371 aa)
B1806_03735Unannotated protein. (455 aa)
B1806_14505Unannotated protein. (386 aa)
B1806_02130Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa)
B1806_10675Unannotated protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (868 aa)
B1806_08550Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (320 aa)
dapAUnannotated protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
B1806_01465Unannotated protein; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. (374 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
GCA_002077135_02232Unannotated protein. (373 aa)
aroAUnannotated protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (441 aa)
trpAUnannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa)
trpBUnannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (409 aa)
trpFUnannotated protein; Belongs to the TrpF family. (211 aa)
asdUnannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
aroCUnannotated protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa)
dapBUnannotated protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (271 aa)
hisIUnannotated protein; In the N-terminal section; belongs to the PRA-CH family. (205 aa)
hisFUnannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
hisAUnannotated protein. (242 aa)
hisHUnannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa)
hisBUnannotated protein; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (373 aa)
hisCUnannotated protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa)
hisDUnannotated protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (436 aa)
hisGUnannotated protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (299 aa)
B1806_15885Unannotated protein. (139 aa)
B1806_15875Unannotated protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (219 aa)
hisSUnannotated protein. (499 aa)
B1806_08280Unannotated protein; In the C-terminal section; belongs to the homoserine dehydrogenase family. (822 aa)
thrBUnannotated protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (316 aa)
B1806_08270Unannotated protein. (431 aa)
cysSUnannotated protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (481 aa)
B1806_14120Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1257 aa)
B1806_02805Unannotated protein. (399 aa)
aroKUnannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa)
aroBUnannotated protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (361 aa)
dapEUnannotated protein; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (377 aa)
B1806_12860Unannotated protein. (469 aa)
metKUnannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (422 aa)
Your Current Organism:
Metallibacterium scheffleri
NCBI taxonomy Id: 993689
Other names: DSM 24874, JCM 17596, M. scheffleri, Metallibacterium scheffleri Ziegler et al. 2013, gamma proteobacterium DKE, strain DKE6
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