STRINGSTRING
ENSOARP00000022813 ENSOARP00000022813 HSPA8 HSPA8 IDH3A IDH3A W5QJA7_SHEEP W5QJA7_SHEEP ENSOARP00000001060 ENSOARP00000001060 GOT2 GOT2 W5P2C3_SHEEP W5P2C3_SHEEP TNNI3 TNNI3 W5NV97_SHEEP W5NV97_SHEEP W5NVG7_SHEEP W5NVG7_SHEEP ENSOARP00000002338 ENSOARP00000002338 OGDHL OGDHL ATP5F1A ATP5F1A SRL SRL FLNC FLNC ACAA2 ACAA2 GPI GPI W5P4S3_SHEEP W5P4S3_SHEEP TPI1 TPI1 ENO3 ENO3 W5P773_SHEEP W5P773_SHEEP MYBPC3 MYBPC3 MYL3 MYL3 PYGB PYGB W5PBE5_SHEEP W5PBE5_SHEEP SLC25A4 SLC25A4 W5PCT5_SHEEP W5PCT5_SHEEP GAPDH GAPDH ANXA6 ANXA6 HADH HADH ATP5F1B ATP5F1B TF TF LOC101117129 LOC101117129 NNT NNT VCL VCL PGK2 PGK2 FH FH CSRP3 CSRP3 CS CS DYRK4 DYRK4 CKM CKM SPTAN1 SPTAN1 ENSOARP00000011724 ENSOARP00000011724 HBA_SHEEP HBA_SHEEP ACAT1 ACAT1 IDH2 IDH2 GOT1 GOT1 ATP5PO ATP5PO MDH2 MDH2 ALB ALB W5PXX8_SHEEP W5PXX8_SHEEP PDHA1 PDHA1 LOC101103029 LOC101103029 OGDH OGDH ENSOARP00000016000 ENSOARP00000016000 UQCRC2 UQCRC2 CKMT2 CKMT2 CRYAB CRYAB HSPD1 HSPD1 HSPA9 HSPA9 PDHA2 PDHA2 ENSOARP00000018574 ENSOARP00000018574 LOC101103784 LOC101103784 MYL2 MYL2 ACO2 ACO2 HADHA HADHA MB MB HADHB HADHB PGK1 PGK1 W5QBX2_SHEEP W5QBX2_SHEEP PKM PKM PARP6 PARP6 W5QCX0_SHEEP W5QCX0_SHEEP HBB HBB LOC101106199 LOC101106199 PFKM PFKM MYH7 MYH7 ENSOARP00000022791 ENSOARP00000022791 LOC101107359 LOC101107359 ENSOARP00000022811 ENSOARP00000022811
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSOARP00000022813annotation not available (105 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (651 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
W5QJA7_SHEEPCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSOARP00000001060annotation not available (105 aa)
GOT2Aspartate aminotransferase. (430 aa)
W5P2C3_SHEEPUncharacterized protein; Belongs to the chaperonin (HSP60) family. (363 aa)
TNNI3Troponin I3, cardiac type. (212 aa)
W5NV97_SHEEPUncharacterized protein. (239 aa)
W5NVG7_SHEEPMyosin_tail_1 domain-containing protein. (128 aa)
ENSOARP00000002338annotation not available (105 aa)
OGDHLOxoglutarate dehydrogenase like. (1013 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
SRLSarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (797 aa)
FLNCFilamin C. (2590 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
W5P4S3_SHEEPCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TPI1Triosephosphate isomerase. (214 aa)
ENO3Enolase 3. (434 aa)
W5P773_SHEEPUncharacterized protein. (314 aa)
MYBPC3Myosin binding protein C, cardiac. (1264 aa)
MYL3Myosin light chain 3. (199 aa)
PYGBGlycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (844 aa)
W5PBE5_SHEEPATP-synt_ab_C domain-containing protein. (106 aa)
SLC25A4Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
W5PCT5_SHEEPUncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (262 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
ANXA6Annexin. (753 aa)
HADHHydroxyacyl-CoA dehydrogenase. (314 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
TFTransferrin; Belongs to the transferrin family. (704 aa)
LOC101117129Uncharacterized protein; Belongs to the transferrin family. (705 aa)
NNTNAD(P) transhydrogenase, mitochondrial; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity). In the N-terminal section; belongs to the AlaDH/PNT family. (1082 aa)
VCLVinculin. (1069 aa)
PGK2Phosphoglycerate kinase. (417 aa)
FHFumarate hydratase. (510 aa)
CSRP3Cysteine and glycine-rich protein 3. (194 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (640 aa)
CKMCreatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
SPTAN1SH3 domain-containing protein. (2257 aa)
ENSOARP00000011724annotation not available (105 aa)
HBA_SHEEPHemoglobin subunit alpha-1/2; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (143 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (434 aa)
GOT1Aspartate aminotransferase. (413 aa)
ATP5POUncharacterized protein. (236 aa)
MDH2Malate dehydrogenase 2. (405 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
W5PXX8_SHEEPUncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (317 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
LOC101103029Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
OGDHOxoglutarate dehydrogenase. (1023 aa)
ENSOARP00000016000annotation not available (105 aa)
UQCRC2Ubiquinol-cytochrome c reductase core protein 2; Belongs to the peptidase M16 family. (453 aa)
CKMT2Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (401 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
HSPD1Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
PDHA2Pyruvate dehydrogenase E1 alpha 2 subunit. (358 aa)
ENSOARP00000018574annotation not available (105 aa)
LOC101103784Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MYL2Myosin light chain 2. (166 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (783 aa)
HADHAEnoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
PGK1Phosphoglycerate kinase. (420 aa)
W5QBX2_SHEEPUncharacterized protein. (238 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (567 aa)
PARP6Poly [ADP-ribose] polymerase. (610 aa)
W5QCX0_SHEEPGLOBIN domain-containing protein; Belongs to the globin family. (143 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (146 aa)
LOC101106199Hemoglobin fetal subunit beta. (146 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (855 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
ENSOARP00000022791annotation not available (105 aa)
LOC101107359Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSOARP00000022811annotation not available (105 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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