STRINGSTRING
PTK2 PTK2 ITGB6 ITGB6 ITGA1 ITGA1 ITGA8 ITGA8 VCL VCL PTK2B PTK2B PXN PXN ITGB3 ITGB3 TLN1 TLN1 TNR TNR ITGA5 ITGA5 ITGB1 ITGB1 SRC SRC VTN VTN ITGB5 ITGB5 ITGA10 ITGA10 TLN2 TLN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1101 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (787 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1166 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1064 aa)
VCLVinculin. (1069 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (589 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
TLN1Talin 1. (2542 aa)
TNRTenascin R. (1358 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1078 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
SRCTyrosine-protein kinase. (541 aa)
VTNSMB domain-containing protein. (475 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
TLN2Talin 2. (2557 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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