11 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOCS3	Suppressor of cytokine signaling 3. (229 aa)
	STAT5A	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. (788 aa)
	STAT3	Signal transducer and activator of transcription. (825 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (393 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	STAT2	Signal transducer and activator of transcription. (849 aa)
	JAK2	Tyrosine-protein kinase. (1133 aa)
	STAT1	Signal transducer and activator of transcription. (804 aa)
	TYK2	Tyrosine-protein kinase. (1161 aa)
	STAT5B	Signal transducer and activator of transcription. (791 aa)
	IRF9	Interferon regulatory factor 9. (462 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRF9	JAK2	ENSOARP00000020626	ENSOARP00000014454	Interferon regulatory factor 9.	Tyrosine-protein kinase.	0.616
IRF9	STAT1	ENSOARP00000020626	ENSOARP00000014920	Interferon regulatory factor 9.	Signal transducer and activator of transcription.	0.999
IRF9	STAT2	ENSOARP00000020626	ENSOARP00000009831	Interferon regulatory factor 9.	Signal transducer and activator of transcription.	0.999
IRF9	STAT3	ENSOARP00000020626	ENSOARP00000001576	Interferon regulatory factor 9.	Signal transducer and activator of transcription.	0.877
IRF9	STAT5A	ENSOARP00000020626	ENSOARP00000000859	Interferon regulatory factor 9.	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.	0.705
IRF9	STAT5B	ENSOARP00000020626	ENSOARP00000020368	Interferon regulatory factor 9.	Signal transducer and activator of transcription.	0.868
IRF9	STAT6	ENSOARP00000020626	ENSOARP00000008144	Interferon regulatory factor 9.	Signal transducer and activator of transcription.	0.853
IRF9	TYK2	ENSOARP00000020626	ENSOARP00000017200	Interferon regulatory factor 9.	Tyrosine-protein kinase.	0.928
JAK2	IRF9	ENSOARP00000014454	ENSOARP00000020626	Tyrosine-protein kinase.	Interferon regulatory factor 9.	0.616
JAK2	PTPN2	ENSOARP00000014454	ENSOARP00000002031	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.957
JAK2	SOCS3	ENSOARP00000014454	ENSOARP00000000153	Tyrosine-protein kinase.	Suppressor of cytokine signaling 3.	0.999
JAK2	STAT1	ENSOARP00000014454	ENSOARP00000014920	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.994
JAK2	STAT2	ENSOARP00000014454	ENSOARP00000009831	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.993
JAK2	STAT3	ENSOARP00000014454	ENSOARP00000001576	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.999
JAK2	STAT5A	ENSOARP00000014454	ENSOARP00000000859	Tyrosine-protein kinase.	Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.	0.978
JAK2	STAT5B	ENSOARP00000014454	ENSOARP00000020368	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.997
JAK2	STAT6	ENSOARP00000014454	ENSOARP00000008144	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.994
JAK2	TYK2	ENSOARP00000014454	ENSOARP00000017200	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.967
PTPN2	JAK2	ENSOARP00000002031	ENSOARP00000014454	Tyrosine-protein phosphatase non-receptor type.	Tyrosine-protein kinase.	0.957
PTPN2	STAT1	ENSOARP00000002031	ENSOARP00000014920	Tyrosine-protein phosphatase non-receptor type.	Signal transducer and activator of transcription.	0.970