48 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL2L1	Bcl-x long protein. (233 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (770 aa)
	ENSOARP00000002338	annotation not available (105 aa)
	TRADD	TNFRSF1A associated via death domain. (339 aa)
	W5NYE2_SHEEP	Uncharacterized protein. (131 aa)
	W5P3K2_SHEEP	Uncharacterized protein. (43 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (142 aa)
	TRAF1	TNF receptor-associated factor. (415 aa)
	W5P6Q4_SHEEP	Death domain-containing protein. (689 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (473 aa)
	BCL2	BCL2 apoptosis regulator. (139 aa)
	BAD	BCL2 associated agonist of cell death. (179 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (623 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	GAS2	Growth arrest specific 2. (314 aa)
	ENDOG	Endonuclease. (299 aa)
	W5PIJ4_SHEEP	CASPASE_P10 domain-containing protein; Belongs to the peptidase C14A family. (82 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	DIABLO	Uncharacterized protein. (270 aa)
	W5PSA5_SHEEP	BH4_2 domain-containing protein. (233 aa)
	BAX	BCL2 associated X, apoptosis regulator. (194 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (301 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1251 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa)
	XIAP	X-linked inhibitor of apoptosis. (570 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (277 aa)
	FAS	Fas cell surface death receptor. (326 aa)
	BCL2A1	BCL2 related protein A1. (175 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (511 aa)
	CASP10	Uncharacterized protein. (219 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (488 aa)
	W5Q767_SHEEP	TNFR-Cys domain-containing protein. (116 aa)
	LOC101103784	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	BOK	BCL2 family apoptosis regulator BOK. (172 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (461 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (210 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (501 aa)
	W5QCU2_SHEEP	Uncharacterized protein. (148 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (287 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (268 aa)
	BCL2L10	Uncharacterized protein. (193 aa)
	LOC101107359	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	ENSOARP00000014077	ENSOARP00000010796	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.760
APAF1	BAX	ENSOARP00000014077	ENSOARP00000013336	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.634
APAF1	BCL2	ENSOARP00000014077	ENSOARP00000006703	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.887
APAF1	BCL2A1	ENSOARP00000014077	ENSOARP00000016272	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 related protein A1.	0.614
APAF1	BCL2L1	ENSOARP00000014077	ENSOARP00000001303	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-x long protein.	0.696
APAF1	BCL2L10	ENSOARP00000014077	ENSOARP00000022516	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.599
APAF1	BCL2L11	ENSOARP00000014077	ENSOARP00000015392	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.559
APAF1	BID	ENSOARP00000014077	ENSOARP00000014489	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.549
APAF1	BIRC2	ENSOARP00000014077	ENSOARP00000006949	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 2.	0.732
APAF1	BIRC5	ENSOARP00000014077	ENSOARP00000005854	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 5.	0.668
APAF1	BOK	ENSOARP00000014077	ENSOARP00000018938	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 family apoptosis regulator BOK.	0.599
APAF1	CASP10	ENSOARP00000014077	ENSOARP00000018158	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.786
APAF1	CASP2	ENSOARP00000014077	ENSOARP00000019018	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.915
APAF1	CASP3	ENSOARP00000014077	ENSOARP00000008016	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.996
APAF1	CASP7	ENSOARP00000014077	ENSOARP00000013762	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.890
APAF1	CASP8	ENSOARP00000014077	ENSOARP00000018175	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.961
APAF1	CASP9	ENSOARP00000014077	ENSOARP00000010405	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSOARP00000014077	ENSOARP00000018098	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.754
APAF1	DIABLO	ENSOARP00000014077	ENSOARP00000012527	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.827
APAF1	ENDOG	ENSOARP00000014077	ENSOARP00000010047	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Endonuclease.	0.676