(12 nodes) Apoptosis - multiple species network (Ovis aries)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BIRC5	Baculoviral IAP repeat containing 5. (142 aa)
	BCL2	BCL2 apoptosis regulator. (139 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (623 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	DIABLO	Uncharacterized protein. (270 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (301 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1251 aa)
	XIAP	X-linked inhibitor of apoptosis. (570 aa)
	LOC101103784	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LOC101107359	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BCL2	ENSOARP00000014077	ENSOARP00000006703	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.887
APAF1	BIRC2	ENSOARP00000014077	ENSOARP00000006949	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 2.	0.732
APAF1	BIRC5	ENSOARP00000014077	ENSOARP00000005854	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 5.	0.668
APAF1	CASP3	ENSOARP00000014077	ENSOARP00000008016	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.996
APAF1	CASP7	ENSOARP00000014077	ENSOARP00000013762	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.890
APAF1	CASP9	ENSOARP00000014077	ENSOARP00000010405	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	DIABLO	ENSOARP00000014077	ENSOARP00000012527	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.827
APAF1	HTRA2	ENSOARP00000014077	ENSOARP00000013708	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	HtrA serine peptidase 2.	0.556
APAF1	LOC101103784	ENSOARP00000014077	ENSOARP00000018630	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC101107359	ENSOARP00000014077	ENSOARP00000022795	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	XIAP	ENSOARP00000014077	ENSOARP00000014796	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	X-linked inhibitor of apoptosis.	0.880
BCL2	APAF1	ENSOARP00000006703	ENSOARP00000014077	BCL2 apoptosis regulator.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.887
BCL2	CASP3	ENSOARP00000006703	ENSOARP00000008016	BCL2 apoptosis regulator.	Caspase 3; Belongs to the peptidase C14A family.	0.936
BCL2	CASP7	ENSOARP00000006703	ENSOARP00000013762	BCL2 apoptosis regulator.	Caspase 7; Belongs to the peptidase C14A family.	0.726
BCL2	CASP9	ENSOARP00000006703	ENSOARP00000010405	BCL2 apoptosis regulator.	Caspase 9; Belongs to the peptidase C14A family.	0.947
BCL2	DIABLO	ENSOARP00000006703	ENSOARP00000012527	BCL2 apoptosis regulator.	Uncharacterized protein.	0.443
BCL2	LOC101103784	ENSOARP00000006703	ENSOARP00000018630	BCL2 apoptosis regulator.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.911
BCL2	LOC101107359	ENSOARP00000006703	ENSOARP00000022795	BCL2 apoptosis regulator.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.902
BCL2	XIAP	ENSOARP00000006703	ENSOARP00000014796	BCL2 apoptosis regulator.	X-linked inhibitor of apoptosis.	0.798
BIRC2	APAF1	ENSOARP00000006949	ENSOARP00000014077	Baculoviral IAP repeat containing 2.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.732