STRINGSTRING
AGER AGER CHMP6 CHMP6 S100A6 S100A6 S100A4 S100A4 DIAPH1 DIAPH1 HEBP2 HEBP2 VTA1 VTA1 CAV1 CAV1 CAV2 CAV2 CD19 CD19 CD82 CD82 CAVIN1 CAVIN1 DNASE1 DNASE1 W5NWJ9_SHEEP W5NWJ9_SHEEP S100A13 S100A13 CDK5 CDK5 PTPN23 PTPN23 CD81 CD81 MAP3K21 MAP3K21 W5P023_SHEEP W5P023_SHEEP IST1 IST1 CDK5R1 CDK5R1 CHMP2A CHMP2A W5P1R2_SHEEP W5P1R2_SHEEP SYNJ2BP SYNJ2BP FLOT2 FLOT2 TOM1L1 TOM1L1 TSPAN4 TSPAN4 WDR27 WDR27 LRFN3 LRFN3 AMN AMN CAPNS1 CAPNS1 TSPAN15 TSPAN15 W5P6P3_SHEEP W5P6P3_SHEEP W5P7D1_SHEEP W5P7D1_SHEEP W5P7F8_SHEEP W5P7F8_SHEEP ARL11 ARL11 GCA GCA KIAA0319 KIAA0319 VPS4B VPS4B GK5 GK5 SNF8 SNF8 PCDH8 PCDH8 CDCP2 CDCP2 VPS4A VPS4A ENSOARP00000007526 ENSOARP00000007526 UBQLNL UBQLNL ANGPTL5 ANGPTL5 MROH7 MROH7 VPS37B VPS37B W5PC69_SHEEP W5PC69_SHEEP CAV3 CAV3 CAVIN4 CAVIN4 ANXA7 ANXA7 CC2D1A CC2D1A ANXA6 ANXA6 CR2 CR2 STAM2 STAM2 CD9 CD9 FKBP14 FKBP14 CHMP4B CHMP4B PALM PALM UBAP1 UBAP1 VPS36 VPS36 SPTY2D1 SPTY2D1 VPS37A VPS37A UEVLD UEVLD TSG101 TSG101 CHMP5 CHMP5 FAM91A1 FAM91A1 ANXA13 ANXA13 ANXA11 ANXA11 CHMP7 CHMP7 EHD1 EHD1 CPD CPD TSPAN9 TSPAN9 W5PM25_SHEEP W5PM25_SHEEP C17orf75 C17orf75 SPAST SPAST W5PN51_SHEEP W5PN51_SHEEP GPHA2 GPHA2 CD63 CD63 DCAF10 DCAF10 OPA3-2 OPA3-2 FLOT1 FLOT1 STAM STAM SRI SRI VPS37D VPS37D MVB12B MVB12B ANXA1 ANXA1 VPS28 VPS28 MITD1 MITD1 CAPN1 CAPN1 MYOC MYOC C12orf43 C12orf43 LGALS1 LGALS1 BROX BROX ANKRD13A ANKRD13A CAVIN2 CAVIN2 CHMP1A CHMP1A MICALL1 MICALL1 CHMP4C CHMP4C W5PZL5_SHEEP W5PZL5_SHEEP ANXA5 ANXA5 AHNAK AHNAK CAPN7 CAPN7 CAPN2 CAPN2 TSPAN19 TSPAN19 HIF1AN HIF1AN SDCBP SDCBP PDCD6IP PDCD6IP VPS37C VPS37C MVB12A MVB12A SCARB2 SCARB2 CHMP2B CHMP2B ICA1L ICA1L SSH1 SSH1 CAST CAST W5Q8P1_SHEEP W5Q8P1_SHEEP TBC1D23 TBC1D23 CYP20A1 CYP20A1 W5Q9V1_SHEEP W5Q9V1_SHEEP HGS HGS TSPAN10 TSPAN10 OLFM3 OLFM3 CAVIN3 CAVIN3 ANXA3 ANXA3 CYB5D2 CYB5D2 FBXL13 FBXL13 MDP1 MDP1 TM9SF1 TM9SF1 KIAA0319L KIAA0319L EHD3 EHD3 ANXA4 ANXA4 TSPAN2 TSPAN2 W5QG65_SHEEP W5QG65_SHEEP PTGFRN PTGFRN ZFYVE19 ZFYVE19 LOC101107266 LOC101107266 ANXA2 ANXA2 S100A10 S100A10 S100A11 S100A11 W5QJ76_SHEEP W5QJ76_SHEEP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGERAdvanced glycosylation end-product specific receptor. (409 aa)
CHMP6Charged multivesicular body protein 6. (180 aa)
S100A6S100 calcium binding protein A6; Belongs to the S-100 family. (86 aa)
S100A4Protein S100; Belongs to the S-100 family. (126 aa)
DIAPH1Diaphanous related formin 1. (1247 aa)
HEBP2Heme binding protein 2. (205 aa)
VTA1Vesicle trafficking 1. (307 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa)
CD19CD19 molecule. (565 aa)
CD82Tetraspanin. (268 aa)
CAVIN1Caveolae associated protein 1. (293 aa)
DNASE1Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (By similarity). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intra [...] (286 aa)
W5NWJ9_SHEEPUncharacterized protein. (87 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PTPN23ALIX_LYPXL_bnd domain-containing protein. (254 aa)
CD81Tetraspanin. (236 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase 21. (855 aa)
W5P023_SHEEPUncharacterized protein; Belongs to the AAA ATPase family. (412 aa)
IST1IST1 factor associated with ESCRT-III. (377 aa)
CDK5R1Cyclin dependent kinase 5 regulatory subunit 1. (300 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
W5P1R2_SHEEPBRO1 domain-containing protein. (259 aa)
SYNJ2BPPDZ domain-containing protein. (145 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (473 aa)
TOM1L1Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (479 aa)
TSPAN4Tetraspanin. (185 aa)
WDR27Uncharacterized protein. (803 aa)
LRFN3Leucine rich repeat and fibronectin type III domain containing 3. (628 aa)
AMNUncharacterized protein. (70 aa)
CAPNS1Calpain small subunit 1. (265 aa)
TSPAN15Tetraspanin. (277 aa)
W5P6P3_SHEEPUncharacterized protein. (133 aa)
W5P7D1_SHEEPUncharacterized protein. (81 aa)
W5P7F8_SHEEPTetraspanin. (236 aa)
ARL11ADP ribosylation factor like GTPase 11; Belongs to the small GTPase superfamily. Arf family. (180 aa)
GCAGrancalcin. (201 aa)
KIAA0319KIAA0319. (1066 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
GK5Glycerol kinase 5; Belongs to the FGGY kinase family. (533 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
PCDH8Uncharacterized protein. (255 aa)
CDCP2CUB domain containing protein 2. (488 aa)
VPS4AATPase_AAA_core domain-containing protein. (107 aa)
ENSOARP00000007526annotation not available (107 aa)
UBQLNLUbiquilin like. (598 aa)
ANGPTL5Angiopoietin like 5. (388 aa)
MROH7Uncharacterized protein. (1324 aa)
VPS37BVPS37B subunit of ESCRT-I. (246 aa)
W5PC69_SHEEPUncharacterized protein. (117 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (177 aa)
CAVIN4Caveolae associated protein 4. (361 aa)
ANXA7Annexin. (467 aa)
CC2D1ACoiled-coil and C2 domain containing 1A. (1143 aa)
ANXA6Annexin. (753 aa)
CR2Uncharacterized protein. (1473 aa)
STAM2Signal transducing adaptor molecule 2. (527 aa)
CD9Tetraspanin. (219 aa)
FKBP14Peptidylprolyl isomerase. (211 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
PALMParalemmin. (402 aa)
UBAP1Ubiquitin associated protein 1. (502 aa)
VPS36Vacuolar protein sorting 36 homolog. (354 aa)
SPTY2D1SPT2 chromatin protein domain containing 1. (684 aa)
VPS37AVPS37A subunit of ESCRT-I. (398 aa)
UEVLDUEV and lactate/malate dehyrogenase domains. (471 aa)
TSG101Tumor susceptibility 101. (391 aa)
CHMP5Uncharacterized protein. (221 aa)
FAM91A1Family with sequence similarity 91 member A1. (836 aa)
ANXA13Annexin. (283 aa)
ANXA11Annexin. (570 aa)
CHMP7Charged multivesicular body protein 7. (452 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (489 aa)
CPDCarboxypeptidase D. (1318 aa)
TSPAN9Tetraspanin-9. (252 aa)
W5PM25_SHEEPUncharacterized protein. (162 aa)
C17orf75Chromosome 17 open reading frame 75. (400 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (624 aa)
W5PN51_SHEEPUncharacterized protein. (219 aa)
GPHA2Glycoprotein hormone subunit alpha 2. (129 aa)
CD63Tetraspanin. (237 aa)
DCAF10DDB1 and CUL4 associated factor 10. (567 aa)
OPA3-2Uncharacterized protein. (190 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (429 aa)
STAMSignal transducing adaptor molecule. (534 aa)
SRIUncharacterized protein. (209 aa)
VPS37DVPS37D subunit of ESCRT-I. (262 aa)
MVB12BMultivesicular body subunit 12B. (288 aa)
ANXA1Annexin. (346 aa)
VPS28VPS28 subunit of ESCRT-I; Belongs to the VPS28 family. (231 aa)
MITD1Microtubule interacting and trafficking domain containing 1. (249 aa)
CAPN1Uncharacterized protein; Belongs to the peptidase C2 family. (729 aa)
MYOCMyocilin. (499 aa)
C12orf43Chromosome 12 open reading frame 43. (262 aa)
LGALS1Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase (By similarity). Strong inducer of T-cell apoptosis. (108 aa)
BROXBRO1 domain and CAAX motif containing. (412 aa)
ANKRD13AAnkyrin repeat domain 13A. (702 aa)
CAVIN2Caveolae associated protein 2. (464 aa)
CHMP1ACharged multivesicular body protein 1A. (196 aa)
MICALL1MICAL like 1. (812 aa)
CHMP4CCharged multivesicular body protein 4C. (236 aa)
W5PZL5_SHEEPAnnexin. (311 aa)
ANXA5Annexin. (339 aa)
AHNAKAHNAK nucleoprotein. (5524 aa)
CAPN7Calpain 7; Belongs to the peptidase C2 family. (769 aa)
CAPN2Uncharacterized protein; Belongs to the peptidase C2 family. (599 aa)
TSPAN19Tetraspanin. (248 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (388 aa)
SDCBPSyndecan binding protein. (360 aa)
PDCD6IPBRO1 domain-containing protein. (875 aa)
VPS37CVPS37C subunit of ESCRT-I. (261 aa)
MVB12AMultivesicular body subunit 12A. (271 aa)
SCARB2Uncharacterized protein; Belongs to the CD36 family. (439 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
ICA1LIslet cell autoantigen 1 like. (491 aa)
SSH1Slingshot protein phosphatase 1. (983 aa)
CASTCalpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue (By similarity); Belongs to the protease inhibitor I27 (calpastatin) family. (786 aa)
W5Q8P1_SHEEPUMA domain-containing protein. (372 aa)
TBC1D23TBC1 domain family member 23. (700 aa)
CYP20A1Cytochrome P450 family 20 subfamily A member 1. (462 aa)
W5Q9V1_SHEEPTetraspanin. (246 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (787 aa)
TSPAN10Tetraspanin. (312 aa)
OLFM3Olfactomedin 3. (478 aa)
CAVIN3Caveolae associated protein 3. (271 aa)
ANXA3Annexin. (323 aa)
CYB5D2Cytochrome b5 domain containing 2; Belongs to the cytochrome b5 family. (242 aa)
FBXL13F-box and leucine rich repeat protein 13. (871 aa)
MDP1Uncharacterized protein. (165 aa)
TM9SF1Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (757 aa)
KIAA0319LKIAA0319 like. (1188 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (531 aa)
ANXA4Annexin. (320 aa)
TSPAN2Tetraspanin. (200 aa)
W5QG65_SHEEPUncharacterized protein. (188 aa)
PTGFRNProstaglandin F2 receptor inhibitor. (882 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (427 aa)
LOC101107266Uncharacterized protein. (222 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. (339 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
S100A11Protein S100; Belongs to the S-100 family. (106 aa)
W5QJ76_SHEEPPDZ domain-containing protein. (124 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (14%) [HD]