72 items (Ovis aries) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NPR1	Guanylate cyclase. (1064 aa)
	NPPC	C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (92 aa)
	ENSOARP00000001048	annotation not available (92 aa)
	AVPR2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
	PSTPIP1	Proline-serine-threonine phosphatase interacting protein 1. (416 aa)
	AQP10	Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (284 aa)
	SLC14A1	Urea transporter 1; Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across [...] (439 aa)
	GASK1A	Golgi associated kinase 1A. (598 aa)
	RSPH3	Radial spoke head 3. (491 aa)
	SCOC	Uncharacterized protein. (120 aa)
	PPP1R21	Protein phosphatase 1 regulatory subunit 21. (780 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (377 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa)
	PDE3B	Phosphodiesterase. (1110 aa)
	W5PAE2_SHEEP	AlbA_2 domain-containing protein. (571 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	PDE4D	Phosphodiesterase. (674 aa)
	W5PBZ0_SHEEP	GP-PDE domain-containing protein. (568 aa)
	AKAP1	A-kinase anchoring protein 1. (767 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
	W5PG33_SHEEP	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (659 aa)
	PRKX	Uncharacterized protein. (305 aa)
	PDGFRL	Platelet derived growth factor receptor like. (375 aa)
	AQP3	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
	AQP7	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (333 aa)
	W5PK17_SHEEP	Uncharacterized protein. (75 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2626 aa)
	GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (628 aa)
	W5PLE2_SHEEP	Uncharacterized protein. (93 aa)
	PDE9A	Phosphodiesterase. (554 aa)
	W5PNS7_SHEEP	Uncharacterized protein. (61 aa)
	SPR	Sepiapterin reductase. (267 aa)
	W5PQ13_SHEEP	Uncharacterized protein. (433 aa)
	NPR2	Guanylate cyclase. (1066 aa)
	NECAP2	NECAP endocytosis associated 2. (268 aa)
	MOSPD1	Motile sperm domain containing 1. (213 aa)
	NPR3	Natriuretic peptide receptor 3. (517 aa)
	W5PRK3_SHEEP	Cyclic nucleotide-binding domain-containing protein. (213 aa)
	GPR161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (533 aa)
	W5PU74_SHEEP	Guanylate cyclase. (1041 aa)
	PRKG1	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	W5PZE0_SHEEP	Uncharacterized protein. (85 aa)
	W5PZF6_SHEEP	PKcGMP_CC domain-containing protein. (82 aa)
	FBXO16	F-box domain-containing protein. (363 aa)
	PRKAR1A	Uncharacterized protein. (411 aa)
	MAP7D2	MAP7 domain containing 2. (708 aa)
	CNBD2	Cyclic nucleotide binding domain containing 2. (583 aa)
	THAP6	THAP domain containing 6. (222 aa)
	PDE5A	Phosphodiesterase. (865 aa)
	PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha. (305 aa)
	PTS	6-pyruvoyltetrahydropterin synthase. (144 aa)
	HEXD	Glyco_hydro_20 domain-containing protein. (477 aa)
	AKAP10	A-kinase anchoring protein 10. (655 aa)
	GUCY2F	Guanylate cyclase. (1108 aa)
	AQP6	Aquaporin 6; Belongs to the MIP/aquaporin (TC 1.A.8) family. (281 aa)
	AQP5	Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
	AQP2	Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (312 aa)
	NPPB	Brain natriuretic peptide 26; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (97 aa)
	NPPA	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa)
	W5QAF7_SHEEP	Dystrobrevin. (651 aa)
	AQP8	Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (289 aa)
	PRKG2	cGMP-dependent protein kinase. (762 aa)
	GCHFR	GTP cyclohydrolase I feedback regulator. (84 aa)
	GUCA2B	Guanylate cyclase activator 2B. (113 aa)
	GUCA2A	Uncharacterized protein. (114 aa)
	W5QGU8_SHEEP	Uncharacterized protein. (49 aa)
	PDE3A	Phosphodiesterase. (829 aa)
	GUCY2C	Guanylate cyclase. (1072 aa)
	AQP9	Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
	GCH1	GTP cyclohydrolase 1. (254 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP1	CNBD2	ENSOARP00000008188	ENSOARP00000016423	A-kinase anchoring protein 1.	Cyclic nucleotide binding domain containing 2.	0.465
AKAP1	PRKACA	ENSOARP00000008188	ENSOARP00000006933	A-kinase anchoring protein 1.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.806
AKAP1	PRKACB	ENSOARP00000008188	ENSOARP00000014812	A-kinase anchoring protein 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.806
AKAP1	PRKAR1A	ENSOARP00000008188	ENSOARP00000016120	A-kinase anchoring protein 1.	Uncharacterized protein.	0.575
AKAP1	PRKAR2A	ENSOARP00000008188	ENSOARP00000017324	A-kinase anchoring protein 1.	Protein kinase cAMP-dependent type II regulatory subunit alpha.	0.691
AKAP1	PRKAR2B	ENSOARP00000008188	ENSOARP00000005311	A-kinase anchoring protein 1.	Protein kinase cAMP-dependent type II regulatory subunit beta.	0.667
AKAP1	PRKX	ENSOARP00000008188	ENSOARP00000009547	A-kinase anchoring protein 1.	Uncharacterized protein.	0.663
AKAP1	THAP6	ENSOARP00000008188	ENSOARP00000016444	A-kinase anchoring protein 1.	THAP domain containing 6.	0.508
AKAP1	W5PRK3_SHEEP	ENSOARP00000008188	ENSOARP00000013082	A-kinase anchoring protein 1.	Cyclic nucleotide-binding domain-containing protein.	0.575
AKAP10	CNBD2	ENSOARP00000018892	ENSOARP00000016423	A-kinase anchoring protein 10.	Cyclic nucleotide binding domain containing 2.	0.673
AKAP10	PRKACA	ENSOARP00000018892	ENSOARP00000006933	A-kinase anchoring protein 10.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.652
AKAP10	PRKACB	ENSOARP00000018892	ENSOARP00000014812	A-kinase anchoring protein 10.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.688
AKAP10	PRKAR1A	ENSOARP00000018892	ENSOARP00000016120	A-kinase anchoring protein 10.	Uncharacterized protein.	0.980
AKAP10	PRKAR2A	ENSOARP00000018892	ENSOARP00000017324	A-kinase anchoring protein 10.	Protein kinase cAMP-dependent type II regulatory subunit alpha.	0.807
AKAP10	PRKAR2B	ENSOARP00000018892	ENSOARP00000005311	A-kinase anchoring protein 10.	Protein kinase cAMP-dependent type II regulatory subunit beta.	0.807
AKAP10	PRKG1	ENSOARP00000018892	ENSOARP00000014606	A-kinase anchoring protein 10.	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	0.551
AKAP10	PRKG2	ENSOARP00000018892	ENSOARP00000020488	A-kinase anchoring protein 10.	cGMP-dependent protein kinase.	0.551
AKAP10	PRKX	ENSOARP00000018892	ENSOARP00000009547	A-kinase anchoring protein 10.	Uncharacterized protein.	0.552
AKAP10	THAP6	ENSOARP00000018892	ENSOARP00000016444	A-kinase anchoring protein 10.	THAP domain containing 6.	0.523
AKAP10	W5PRK3_SHEEP	ENSOARP00000018892	ENSOARP00000013082	A-kinase anchoring protein 10.	Cyclic nucleotide-binding domain-containing protein.	0.980