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ALDOC ALDOC HK3 HK3 G6PC G6PC G6PC2 G6PC2 MYCBPAP MYCBPAP ALDOA ALDOA PKLR PKLR G6PD G6PD PGAM1 PGAM1 GPI GPI ENO2 ENO2 PGD PGD HKDC1 HKDC1 TPI1 TPI1 TKTL1 TKTL1 HK1 HK1 ENO3 ENO3 TALDO1 TALDO1 G6PC3 G6PC3 ALDOB ALDOB BPGM BPGM GAPDH GAPDH FBP1 FBP1 FBP2 FBP2 PGK2 PGK2 H6PD H6PD ENO1 ENO1 PGM2 PGM2 W5PK04_SHEEP W5PK04_SHEEP W5PLR0_SHEEP W5PLR0_SHEEP PFKL PFKL HK2 HK2 PGAM2 PGAM2 PFKP PFKP W5PYK2_SHEEP W5PYK2_SHEEP GCK GCK PGLS PGLS TKT TKT RBM45 RBM45 W5Q7K8_SHEEP W5Q7K8_SHEEP PCK1 PCK1 ENO4 ENO4 W5QBT3_SHEEP W5QBT3_SHEEP PGK1 PGK1 PARP6 PARP6 ADPGK ADPGK RPE RPE PCK2 PCK2 PFKM PFKM DERA DERA RPIA RPIA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (459 aa)
HK3Hexokinase 3. (951 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
G6PC2Glucose-6-phosphatase catalytic subunit 2. (359 aa)
MYCBPAPMYCBP associated protein. (964 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (593 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
PGAM1Uncharacterized protein. (208 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
ENO2Enolase 2. (434 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (542 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
TPI1Triosephosphate isomerase. (214 aa)
TKTL1Transketolase like 1. (622 aa)
HK1Hexokinase 1. (921 aa)
ENO3Enolase 3. (434 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (245 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (341 aa)
ALDOBFructose-bisphosphate aldolase B. (364 aa)
BPGMPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
FBP1Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (338 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
PGK2Phosphoglycerate kinase. (417 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (767 aa)
ENO1Enolase 1. (452 aa)
PGM2Phosphoglucomutase 2; Belongs to the phosphohexose mutase family. (582 aa)
W5PK04_SHEEPPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (200 aa)
W5PLR0_SHEEPUncharacterized protein. (506 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (752 aa)
HK2Hexokinase 2. (922 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (256 aa)
PFKP6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (790 aa)
W5PYK2_SHEEPEnolase_C domain-containing protein. (317 aa)
GCKPhosphotransferase. (465 aa)
PGLS6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (258 aa)
TKTTransketolase. (623 aa)
RBM45RNA binding motif protein 45. (471 aa)
W5Q7K8_SHEEPGp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (286 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (620 aa)
ENO4Enolase 4. (613 aa)
W5QBT3_SHEEPGlyceraldehyde-3-phosphate dehydrogenase. (327 aa)
PGK1Phosphoglycerate kinase. (420 aa)
PARP6Poly [ADP-ribose] polymerase. (610 aa)
ADPGKADP dependent glucokinase. (435 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (724 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (855 aa)
DERAUncharacterized protein. (309 aa)
RPIARibose 5-phosphate isomerase A. (306 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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