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ECI2 ECI2 ECHS1 ECHS1 ACSBG1 ACSBG1 W5NRG4_SHEEP W5NRG4_SHEEP HSD17B4 HSD17B4 ACACA ACACA ALDH6A1 ALDH6A1 W5NTP6_SHEEP W5NTP6_SHEEP CHAT CHAT AASDHPPT AASDHPPT FASN FASN ACYP2 ACYP2 AASDH AASDH SLC27A5 SLC27A5 ETFDH ETFDH ACAA2 ACAA2 OXSM OXSM PCCA PCCA ACAT2 ACAT2 SCP2D1 SCP2D1 CARTPT CARTPT ABAT ABAT W5P744_SHEEP W5P744_SHEEP ECH1 ECH1 W5P7D6_SHEEP W5P7D6_SHEEP CPT2 CPT2 ACSBG2 ACSBG2 HMGCLL1 HMGCLL1 HSDL2 HSDL2 ALDH5A1 ALDH5A1 ACSS1 ACSS1 ACOT8 ACOT8 HMGCL HMGCL W5PCD6_SHEEP W5PCD6_SHEEP ACSL1 ACSL1 ECHDC1 ECHDC1 AUH AUH PCCB PCCB CDYL2 CDYL2 HADH HADH ACOX1 ACOX1 HSD17B8 HSD17B8 CRAT CRAT OXCT1 OXCT1 ACADSB ACADSB HIBADH HIBADH GCDH GCDH W5PKE2_SHEEP W5PKE2_SHEEP ALDH2 ALDH2 ACADVL ACADVL ACSS2 ACSS2 ACAT1 ACAT1 AGXT2 AGXT2 ALDH9A1 ALDH9A1 BDH2 BDH2 ACSL5 ACSL5 AMACR AMACR ACOX2 ACOX2 ACSM5 ACSM5 ACADS ACADS CPT1C CPT1C ACAD8 ACAD8 ACSF3 ACSF3 CROT CROT HTD2 HTD2 W5PXX8_SHEEP W5PXX8_SHEEP BBOX1 BBOX1 ACSS3 ACSS3 ACOT12 ACOT12 LOC101111965 LOC101111965 CBR4 CBR4 ACSL6 ACSL6 SLC25A20 SLC25A20 HIBCH HIBCH W5Q4K3_SHEEP W5Q4K3_SHEEP ACACB ACACB SLC27A1 SLC27A1 CPT1A CPT1A W5Q6U0_SHEEP W5Q6U0_SHEEP W5Q8A9_SHEEP W5Q8A9_SHEEP ACSL4 ACSL4 ECI1 ECI1 ALDH3A2 ALDH3A2 W5QB30_SHEEP W5QB30_SHEEP HADHA HADHA HADHB HADHB MCAT MCAT ACADL ACADL CPT1B CPT1B W5QFN4_SHEEP W5QFN4_SHEEP OXCT2 OXCT2 ACSL3 ACSL3 BDH1 BDH1 HMGCS2 HMGCS2 EHHADH EHHADH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ECI2Enoyl-CoA delta isomerase 2. (399 aa)
ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (775 aa)
W5NRG4_SHEEPADH_zinc_N domain-containing protein. (128 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (737 aa)
ACACAAcetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. (2257 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (536 aa)
W5NTP6_SHEEPETF domain-containing protein. (297 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (651 aa)
AASDHPPTAminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa)
FASNUncharacterized protein. (183 aa)
ACYP2Acylphosphatase. (80 aa)
AASDHAminoadipate-semialdehyde dehydrogenase. (1107 aa)
SLC27A5Solute carrier family 27 member 5. (503 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (617 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
OXSM3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa)
PCCAPropionyl-CoA carboxylase subunit alpha. (646 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
SCP2D1SCP2 sterol binding domain containing 1. (156 aa)
CARTPTCART prepropeptide. (90 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
W5P744_SHEEP3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (266 aa)
ECH1Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (388 aa)
W5P7D6_SHEEPUncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (203 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (672 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (266 aa)
HSDL2Hydroxysteroid dehydrogenase like 2. (418 aa)
ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (447 aa)
ACSS1Acetyl-coenzyme A synthetase. (579 aa)
ACOT8Acyl-CoA thioesterase 8. (316 aa)
HMGCL3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa)
W5PCD6_SHEEPUncharacterized protein. (403 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (734 aa)
ECHDC1Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (307 aa)
AUHAU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (230 aa)
PCCBPropionyl-CoA carboxylase subunit beta. (550 aa)
CDYL2Chromodomain Y like 2. (494 aa)
HADHHydroxyacyl-CoA dehydrogenase. (314 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (642 aa)
HSD17B8Hydroxysteroid 17-beta dehydrogenase 8. (259 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
OXCT1Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (520 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (434 aa)
HIBADHUncharacterized protein. (330 aa)
GCDHGlutaryl-CoA dehydrogenase. (439 aa)
W5PKE2_SHEEPETF domain-containing protein. (274 aa)
ALDH2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (520 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (707 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
ALDH9A1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (469 aa)
BDH23-hydroxybutyrate dehydrogenase 2. (245 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (684 aa)
AMACRAlpha-methylacyl-CoA racemase. (385 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (682 aa)
ACSM5Acyl-CoA synthetase medium chain family member 5. (597 aa)
ACADSAcyl-CoA dehydrogenase short chain. (406 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (799 aa)
ACAD8Acyl-CoA dehydrogenase family member 8. (402 aa)
ACSF3Uncharacterized protein. (363 aa)
CROTCarnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (612 aa)
HTD2Hydroxyacyl-thioester dehydratase type 2. (168 aa)
W5PXX8_SHEEPUncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (317 aa)
BBOX1Gamma-butyrobetaine hydroxylase 1. (387 aa)
ACSS3Acyl-CoA synthetase short chain family member 3. (678 aa)
ACOT12Acyl-CoA thioesterase 12. (559 aa)
LOC101111965PKS_ER domain-containing protein. (378 aa)
CBR4Carbonyl reductase 4. (241 aa)
ACSL6AMP-binding domain-containing protein. (721 aa)
SLC25A20Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
W5Q4K3_SHEEPUncharacterized protein. (1345 aa)
ACACBAcetyl-CoA carboxylase beta. (2454 aa)
SLC27A1Solute carrier family 27 member 1. (524 aa)
CPT1AUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (786 aa)
W5Q6U0_SHEEPCarrier domain-containing protein. (2372 aa)
W5Q8A9_SHEEPAcyl-CoA_dh_1 domain-containing protein. (84 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (722 aa)
ECI1Enoyl-CoA delta isomerase 1. (305 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (509 aa)
W5QB30_SHEEPUncharacterized protein. (1061 aa)
HADHAEnoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
MCATMalonyl-CoA-acyl carrier protein transacylase. (392 aa)
ACADLAcyl-CoA dehydrogenase long chain. (432 aa)
CPT1BUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (770 aa)
W5QFN4_SHEEPSuccinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (518 aa)
OXCT2Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (518 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
BDH13-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (344 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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