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RDH5 RDH5 RPE65 RPE65 CYP26B1 CYP26B1 W5PS08_SHEEP W5PS08_SHEEP W5PT13_SHEEP W5PT13_SHEEP ALDH1A1 ALDH1A1 AKR1E2 AKR1E2 DGAT1 DGAT1 RDH8 RDH8 DHRS3 DHRS3 ALDH8A1 ALDH8A1 AWAT2 AWAT2 TTR TTR CRABP2 CRABP2 RDH10 RDH10 W5P6Y5_SHEEP W5P6Y5_SHEEP PNPLA2 PNPLA2 CEL CEL DHRS13 DHRS13 DHRS9 DHRS9 SDR16C5 SDR16C5 LOC101116323 LOC101116323 LOC101111965 LOC101111965 AKR1B1 AKR1B1 W5Q247_SHEEP W5Q247_SHEEP ADH5 ADH5 BCO2 BCO2 LRAT LRAT RDH14 RDH14 ABCA4 ABCA4 LOC101119050 LOC101119050 PLB1 PLB1 RETSAT RETSAT ALDH1A2 ALDH1A2 W5NRG4_SHEEP W5NRG4_SHEEP CRABP1 CRABP1 RARRES2 RARRES2 CYP26C1 CYP26C1 CYP26A1 CYP26A1 W5NUE4_SHEEP W5NUE4_SHEEP W5NUH5_SHEEP W5NUH5_SHEEP RDH13 RDH13 W5NVS0_SHEEP W5NVS0_SHEEP HSD17B1 HSD17B1 W5NW85_SHEEP W5NW85_SHEEP RBP4 RBP4 CYP1A2 CYP1A2 CYP1A1 CYP1A1 DHRS7 DHRS7 RDH11 RDH11 RDH12 RDH12 CYP2S1 CYP2S1 AKR1B10 AKR1B10 LIPE LIPE RDH16 RDH16 SDR9C7 SDR9C7 W5PDZ3_SHEEP W5PDZ3_SHEEP HSD17B6 HSD17B6 BCO1 BCO1 DHRS12 DHRS12 CYP1B1 CYP1B1 W5PIK8_SHEEP W5PIK8_SHEEP ALDH1A3 ALDH1A3 PNPLA4 PNPLA4 W5PKE4_SHEEP W5PKE4_SHEEP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RDH5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (304 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
W5PS08_SHEEPAldo_ket_red domain-containing protein. (298 aa)
W5PT13_SHEEPUncharacterized protein. (521 aa)
ALDH1A1Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo. (501 aa)
AKR1E2Aldo-keto reductase family 1 member E2. (329 aa)
DGAT1Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (497 aa)
RDH8Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (314 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
ALDH8A1Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (339 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (147 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (301 aa)
W5P6Y5_SHEEPUncharacterized protein. (118 aa)
PNPLA2PNPLA domain-containing protein. (246 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (599 aa)
DHRS13Dehydrogenase/reductase 13. (337 aa)
DHRS9Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (380 aa)
SDR16C5Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa)
LOC101116323Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
LOC101111965PKS_ER domain-containing protein. (378 aa)
AKR1B1Aldo_ket_red domain-containing protein. (316 aa)
W5Q247_SHEEPPKS_ER domain-containing protein. (375 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
BCO2Uncharacterized protein. (575 aa)
LRATLRAT domain-containing protein. (229 aa)
RDH14Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (336 aa)
ABCA4ATP binding cassette subfamily A member 4. (2281 aa)
LOC101119050Uncharacterized protein. (279 aa)
PLB1Phospholipase B1. (1463 aa)
RETSATRetinol saturase. (609 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
W5NRG4_SHEEPADH_zinc_N domain-containing protein. (128 aa)
CRABP1Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
RARRES2Retinoic acid receptor responder 2. (162 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (505 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
W5NUE4_SHEEPLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (91 aa)
W5NUH5_SHEEPUncharacterized protein. (281 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (314 aa)
W5NVS0_SHEEPADH_N domain-containing protein. (126 aa)
HSD17B1Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa)
W5NW85_SHEEPLRAT domain-containing protein. (198 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (165 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (521 aa)
CYP1A1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (452 aa)
DHRS7Dehydrogenase/reductase 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa)
RDH11Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
RDH12Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa)
CYP2S1Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (488 aa)
AKR1B10Aldo-keto reductase family 1 member B10. (303 aa)
LIPEUncharacterized protein. (923 aa)
RDH16Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
SDR9C7Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
W5PDZ3_SHEEPUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
HSD17B6Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
BCO1Uncharacterized protein. (595 aa)
DHRS12Dehydrogenase/reductase 12. (317 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa)
W5PIK8_SHEEPLRAT domain-containing protein. (232 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (493 aa)
PNPLA4Patatin like phospholipase domain containing 4. (258 aa)
W5PKE4_SHEEPAldo_ket_red domain-containing protein. (311 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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