18 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (409 aa)
	H3F3A	Histone H3.3. (136 aa)
	LOC101108931	Histone H3; Belongs to the histone H3 family. (136 aa)
	FOXO3	Fork-head domain-containing protein. (473 aa)
	PGRMC1	Uncharacterized protein. (87 aa)
	CDC25B	Cell division cycle 25B. (574 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (585 aa)
	LOC101115386	Histone domain-containing protein. (136 aa)
	FBXO5	F-box protein 5. (413 aa)
	W5P5A8_SHEEP	Histone domain-containing protein. (136 aa)
	EDNRA	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
	WASHC5	WASH complex subunit 5. (1160 aa)
	REC8	REC8 meiotic recombination protein. (592 aa)
	PDE3A	Phosphodiesterase. (829 aa)
	BRCA2	BRCA2 DNA repair associated. (3427 aa)
	W5PNU4_SHEEP	Histone H3; Belongs to the histone H3 family. (136 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (215 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	DMC1	ENSOARP00000011988	ENSOARP00000016725	BRCA2 DNA repair associated.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.869
BRCA2	W5P5A8_SHEEP	ENSOARP00000011988	ENSOARP00000005611	BRCA2 DNA repair associated.	Histone domain-containing protein.	0.528
DMC1	BRCA2	ENSOARP00000016725	ENSOARP00000011988	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	BRCA2 DNA repair associated.	0.869
DMC1	REC8	ENSOARP00000016725	ENSOARP00000020623	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	REC8 meiotic recombination protein.	0.921
DMC1	TRIP13	ENSOARP00000016725	ENSOARP00000017264	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.724
EDN1	EDNRA	ENSOARP00000015104	ENSOARP00000008763	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.999
EDNRA	EDN1	ENSOARP00000008763	ENSOARP00000015104	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.999
FOXO3	W5P5A8_SHEEP	ENSOARP00000011521	ENSOARP00000005611	Fork-head domain-containing protein.	Histone domain-containing protein.	0.419
H3F3A	W5P5A8_SHEEP	ENSOARP00000019160	ENSOARP00000005611	Histone H3.3.	Histone domain-containing protein.	0.562
LOC101108931	W5P5A8_SHEEP	ENSOARP00000010254	ENSOARP00000005611	Histone H3; Belongs to the histone H3 family.	Histone domain-containing protein.	0.562
REC8	DMC1	ENSOARP00000020623	ENSOARP00000016725	REC8 meiotic recombination protein.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.921
REC8	TRIP13	ENSOARP00000020623	ENSOARP00000017264	REC8 meiotic recombination protein.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.485
TRIP13	DMC1	ENSOARP00000017264	ENSOARP00000016725	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.724
TRIP13	REC8	ENSOARP00000017264	ENSOARP00000020623	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	REC8 meiotic recombination protein.	0.485
W5P5A8_SHEEP	BRCA2	ENSOARP00000005611	ENSOARP00000011988	Histone domain-containing protein.	BRCA2 DNA repair associated.	0.528
W5P5A8_SHEEP	FOXO3	ENSOARP00000005611	ENSOARP00000011521	Histone domain-containing protein.	Fork-head domain-containing protein.	0.419
W5P5A8_SHEEP	H3F3A	ENSOARP00000005611	ENSOARP00000019160	Histone domain-containing protein.	Histone H3.3.	0.562
W5P5A8_SHEEP	LOC101108931	ENSOARP00000005611	ENSOARP00000010254	Histone domain-containing protein.	Histone H3; Belongs to the histone H3 family.	0.562