STRINGSTRING
TRPM7 TRPM7 W5PHP2_SHEEP W5PHP2_SHEEP W5PHA3_SHEEP W5PHA3_SHEEP PLCG2 PLCG2 W5PGL9_SHEEP W5PGL9_SHEEP MTM1 MTM1 ROCK1 ROCK1 W5PFN6_SHEEP W5PFN6_SHEEP RASGRP2 RASGRP2 AIF1 AIF1 LCP1 LCP1 EEF1A1-2 EEF1A1-2 HIP1R HIP1R PLEKHA1 PLEKHA1 ASAP3 ASAP3 PAK1 PAK1 AIF1L AIF1L MYO6 MYO6 MTMR14 MTMR14 BCAR1 BCAR1 AKT2 AKT2 FGD1 FGD1 FAP FAP EEF1A1 EEF1A1 EPS8L2 EPS8L2 W5P7W4_SHEEP W5P7W4_SHEEP MKLN1 MKLN1 RINL RINL W5P720_SHEEP W5P720_SHEEP TLR4 TLR4 PDLIM7 PDLIM7 W5P5F5_SHEEP W5P5F5_SHEEP SH3YL1 SH3YL1 PPP1R9B PPP1R9B ARHGEF2 ARHGEF2 NF2 NF2 MTSS2 MTSS2 W5P2V0_SHEEP W5P2V0_SHEEP PSD3 PSD3 ARHGEF26 ARHGEF26 WASF2 WASF2 FGR FGR NME1-NME2 NME1-NME2 FSCN1 FSCN1 LOC101119944 LOC101119944 EZR EZR W5NXJ6_SHEEP W5NXJ6_SHEEP FSCN3-2 FSCN3-2 W5NW47_SHEEP W5NW47_SHEEP W5NW42_SHEEP W5NW42_SHEEP EPS8L1 EPS8L1 CYTH3 CYTH3 CSPG4 CSPG4 FSCN3 FSCN3 PLCG1 PLCG1 W5NU49_SHEEP W5NU49_SHEEP W5NTA5_SHEEP W5NTA5_SHEEP MYADM MYADM ARF6 ARF6 PSD PSD S100A6 S100A6 CTTN CTTN CIB3 CIB3 BAIAP2 BAIAP2 W5NPZ2_SHEEP W5NPZ2_SHEEP DLC1 DLC1 FRMD4B FRMD4B ABCA7 ABCA7 ATP6V1B2 ATP6V1B2 PACSIN1 PACSIN1 PDPN PDPN PTK6 PTK6 W5PN68_SHEEP W5PN68_SHEEP RPS3 RPS3 EEF1A1-3 EEF1A1-3 CD2AP CD2AP ITGB3 ITGB3 TLN1 TLN1 CIB1 CIB1 BMX BMX SLC9A3R1 SLC9A3R1 MYO1C MYO1C INPP5K INPP5K ENSOARP00000013797 ENSOARP00000013797 EPB41L5 EPB41L5 MYO10 MYO10 IQGAP1 IQGAP1 SNTG1 SNTG1 KANK1 KANK1 W5PUP6_SHEEP W5PUP6_SHEEP S100B S100B COBL COBL DBNL DBNL W5PW07_SHEEP W5PW07_SHEEP ARHGAP18 ARHGAP18 EGFR EGFR RHOA RHOA PDXP PDXP FGD2 FGD2 WWC1 WWC1 APPL1 APPL1 W5PYS4_SHEEP W5PYS4_SHEEP JCAD JCAD DDX58 DDX58 IFIT5 IFIT5 ITGB1BP1 ITGB1BP1 ADAM17 ADAM17 MTMR9 MTMR9 KIF18A KIF18A TLNRD1 TLNRD1 RAB5A RAB5A RASA1 RASA1 APC APC W5Q3R0_SHEEP W5Q3R0_SHEEP ITGA5 ITGA5 W5Q4M2_SHEEP W5Q4M2_SHEEP ITGAV ITGAV APPL2 APPL2 PSD2 PSD2 ALS2 ALS2 AMOT AMOT ITGB1 ITGB1 LIMA1 LIMA1 SRC SRC CFL1 CFL1 ARFIP2 ARFIP2 W5QAH5_SHEEP W5QAH5_SHEEP CDK6 CDK6 W5QBM3_SHEEP W5QBM3_SHEEP MYH9 MYH9 PACSIN2 PACSIN2 EPS8L3 EPS8L3 VIL1 VIL1 TWF1 TWF1 PLEK PLEK C2CD5 C2CD5 KNSTRN KNSTRN ACAP2 ACAP2 PLA2G4F PLA2G4F CAPG CAPG EPS8 EPS8 PLEKHO1 PLEKHO1 TLN2 TLN2 PSD4 PSD4 MYO5A MYO5A PIP5K1A PIP5K1A W5QII3_SHEEP W5QII3_SHEEP INPP5J INPP5J THEM4 THEM4 ACTN1 ACTN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRPM7Alpha-type protein kinase domain-containing protein. (1873 aa)
W5PHP2_SHEEPUncharacterized protein. (440 aa)
W5PHA3_SHEEPTr-type G domain-containing protein. (525 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1224 aa)
W5PGL9_SHEEPTr-type G domain-containing protein. (452 aa)
MTM1Myotubularin 1. (603 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1372 aa)
W5PFN6_SHEEPElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (385 aa)
RASGRP2RAS guanyl releasing protein 2. (667 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
LCP1Lymphocyte cytosolic protein 1. (641 aa)
EEF1A1-2Elongation factor 1-alpha 1. (462 aa)
HIP1RHuntingtin interacting protein 1 related. (1033 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (858 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
AIF1LEF-hand domain-containing protein. (119 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
MTMR14Myotubularin related protein 14. (652 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (813 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (455 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (960 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (763 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
EPS8L2PID domain-containing protein. (166 aa)
W5P7W4_SHEEPUncharacterized protein. (557 aa)
MKLN1Muskelin 1. (736 aa)
RINLRas and Rab interactor like. (520 aa)
W5P720_SHEEPTr-type G domain-containing protein. (431 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
PDLIM7PDZ and LIM domain 7. (584 aa)
W5P5F5_SHEEPUncharacterized protein. (121 aa)
SH3YL1SH3 and SYLF domain containing 1. (342 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (716 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1115 aa)
NF2Neurofibromin 2. (628 aa)
MTSS2IMD domain-containing protein. (353 aa)
W5P2V0_SHEEPFERM domain-containing protein. (551 aa)
PSD3Pleckstrin and Sec7 domain containing 3. (1031 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (871 aa)
WASF2WASP family member 2. (504 aa)
FGRTyrosine-protein kinase. (522 aa)
NME1-NME2Nucleoside diphosphate kinase. (268 aa)
FSCN1Fascin actin-bundling protein 1. (520 aa)
LOC101119944Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (459 aa)
EZRFERM domain-containing protein. (553 aa)
W5NXJ6_SHEEPUncharacterized protein. (265 aa)
FSCN3-2Fascin actin-bundling protein 3. (498 aa)
W5NW47_SHEEPMyosin_tail_1 domain-containing protein. (226 aa)
W5NW42_SHEEP4HBT domain-containing protein. (221 aa)
EPS8L1EPS8 like 1. (727 aa)
CYTH3Cytohesin 3. (404 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2320 aa)
FSCN3Fascin. (498 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1201 aa)
W5NU49_SHEEPGTP_EFTU_D3 domain-containing protein. (297 aa)
W5NTA5_SHEEPUncharacterized protein. (465 aa)
MYADMMyeloid associated differentiation marker. (315 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
PSDPleckstrin and Sec7 domain containing. (1027 aa)
S100A6S100 calcium binding protein A6; Belongs to the S-100 family. (86 aa)
CTTNCortactin. (511 aa)
CIB3Calcium and integrin binding family member 3. (187 aa)
BAIAP2BAI1 associated protein 2. (534 aa)
W5NPZ2_SHEEPMyotubularin phosphatase domain-containing protein. (537 aa)
DLC1DLC1 Rho GTPase activating protein. (1523 aa)
FRMD4BFERM domain containing 4B. (1030 aa)
ABCA7ATP binding cassette subfamily A member 7. (2102 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (515 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons 1. (441 aa)
PDPNUncharacterized protein. (168 aa)
PTK6Tyrosine-protein kinase. (450 aa)
W5PN68_SHEEPUncharacterized protein. (287 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
EEF1A1-3Elongation factor 1-alpha 1. (462 aa)
CD2APCD2 associated protein. (638 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
TLN1Talin 1. (2542 aa)
CIB1Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] (217 aa)
BMXTyrosine-protein kinase. (655 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (368 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1067 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (471 aa)
ENSOARP00000013797annotation not available (176 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (729 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2016 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1691 aa)
SNTG1Syntrophin gamma 1. (517 aa)
KANK1KN motif and ankyrin repeat domains 1. (1356 aa)
W5PUP6_SHEEPUncharacterized protein. (921 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
COBLCordon-bleu WH2 repeat protein. (1248 aa)
DBNLDrebrin like. (440 aa)
W5PW07_SHEEPTr-type G domain-containing protein. (370 aa)
ARHGAP18Rho GTPase activating protein 18. (644 aa)
EGFRReceptor protein-tyrosine kinase. (1155 aa)
RHOARHOA. (193 aa)
PDXPPyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily. (296 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (659 aa)
WWC1WW and C2 domain containing 1. (1064 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (693 aa)
W5PYS4_SHEEPPH domain-containing protein. (543 aa)
JCADJunctional cadherin 5 associated. (1310 aa)
DDX58DExD/H-box helicase 58. (943 aa)
IFIT5Interferon induced protein with tetratricopeptide repeats 5. (482 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (204 aa)
ADAM17ADAM metallopeptidase domain 17. (825 aa)
MTMR9Myotubularin related protein 9. (550 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (895 aa)
TLNRD1Talin rod domain containing 1. (318 aa)
RAB5AUncharacterized protein. (215 aa)
RASA1RAS p21 protein activator 1. (1023 aa)
APCAPC regulator of WNT signaling pathway. (2856 aa)
W5Q3R0_SHEEPElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (422 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1078 aa)
W5Q4M2_SHEEPUncharacterized protein. (193 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (645 aa)
PSD2Pleckstrin and Sec7 domain containing 2. (773 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1657 aa)
AMOTAngiomotin. (1089 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
LIMA1LIM domain and actin binding 1. (760 aa)
SRCTyrosine-protein kinase. (541 aa)
CFL1Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity); Belongs to the actin-binding protei [...] (165 aa)
ARFIP2AH domain-containing protein. (341 aa)
W5QAH5_SHEEPUncharacterized protein. (277 aa)
CDK6Cyclin dependent kinase 6. (273 aa)
W5QBM3_SHEEPTr-type G domain-containing protein. (446 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1930 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons 2. (486 aa)
EPS8L3EPS8 like 3. (594 aa)
VIL1Villin 1. (812 aa)
TWF1Twinfilin actin binding protein 1. (384 aa)
PLEKPleckstrin. (350 aa)
C2CD5C2 calcium dependent domain containing 5. (1126 aa)
KNSTRNKinetochore localized astrin (SPAG5) binding protein. (358 aa)
ACAP2ArfGAP with coiled-coil, ankyrin repeat and PH domains 2. (764 aa)
PLA2G4FPhospholipase A2. (859 aa)
CAPGCapping actin protein, gelsolin like. (396 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (845 aa)
PLEKHO1Pleckstrin homology domain containing O1. (440 aa)
TLN2Talin 2. (2557 aa)
PSD4Pleckstrin and Sec7 domain containing 4. (1034 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1883 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (549 aa)
W5QII3_SHEEPTr-type G domain-containing protein. (393 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1014 aa)
THEM4Thioesterase superfamily member 4. (207 aa)
ACTN1Actinin alpha 1. (886 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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