STRINGSTRING
PPP3CB PPP3CB W5PD11_SHEEP W5PD11_SHEEP MYO1A MYO1A WDR64 WDR64 SMTNL1 SMTNL1 STRN STRN MYO1D MYO1D PHKG1 PHKG1 UBR4 UBR4 PPP3CC PPP3CC CNN2 CNN2 SPA17 SPA17 MAPKAPK5 MAPKAPK5 MYO9B MYO9B CAMK2D CAMK2D CNN1 CNN1 MYH7 MYH7 IQCB1 IQCB1 MYLK MYLK IQCG IQCG KCNQ4 KCNQ4 MAP6D1 MAP6D1 MYO1E MYO1E UNC13C UNC13C MARCKSL1 MARCKSL1 KCNH5 KCNH5 SLC8A3 SLC8A3 STRN4 STRN4 CAMSAP3 CAMSAP3 GAP43 GAP43 NOS3 NOS3 W5NV97_SHEEP W5NV97_SHEEP SPEGNB SPEGNB W5NVT1_SHEEP W5NVT1_SHEEP W5NVU9_SHEEP W5NVU9_SHEEP EPB41 EPB41 MKNK1 MKNK1 KCNQ1 KCNQ1 LOC101105884 LOC101105884 KCNN3 KCNN3 W5NYC3_SHEEP W5NYC3_SHEEP ATP5IF1 ATP5IF1 AKAP12 AKAP12 ENKUR ENKUR FBXL20 FBXL20 INVS INVS RYR2 RYR2 IQGAP1 IQGAP1 CACNA1C CACNA1C CAMK1G CAMK1G ADCY1 ADCY1 MYO7A MYO7A PPP3CA PPP3CA W5PWI7_SHEEP W5PWI7_SHEEP KCNQ5 KCNQ5 KCNQ2 KCNQ2 SLC8A2 SLC8A2 CAMKV CAMKV MYH1 MYH1 SPATA17 SPATA17 FBXO41 FBXO41 MAP6 MAP6 NDUFAF4 NDUFAF4 UNC13B UNC13B KCNN1 KCNN1 PHKA2 PHKA2 TRPV4 TRPV4 MKNK2 MKNK2 IQCF3 IQCF3 IQCF2 IQCF2 IQCF5 IQCF5 IQCF1 IQCF1 MYO6 MYO6 KCNQ3 KCNQ3 PYY-2 PYY-2 MAPKAPK2 MAPKAPK2 CAMK1 CAMK1 IQGAP3 IQGAP3 NGFR NGFR CDK5RAP2 CDK5RAP2 ASPM ASPM FAS FAS SYT1 SYT1 CAMK1D CAMK1D SLC9A1 SLC9A1 MYO3A MYO3A NOS1 NOS1 W5P2N0_SHEEP W5P2N0_SHEEP RIT1 RIT1 CAMSAP1 CAMSAP1 PLCB3 PLCB3 RYR1 RYR1 STRN3 STRN3 NRGN NRGN EEF2K EEF2K CAMK2B CAMK2B W5Q2E9_SHEEP W5Q2E9_SHEEP FBXL2 FBXL2 W5PD66_SHEEP W5PD66_SHEEP SNTA1 SNTA1 UNC13A UNC13A PDE1B PDE1B W5Q3L8_SHEEP W5Q3L8_SHEEP KCNN2 KCNN2 CAMK2G CAMK2G MAPKAPK3 MAPKAPK3 CNGA2 CNGA2 MIP MIP ATP2B4 ATP2B4 KCNN4 KCNN4 W5PH02_SHEEP W5PH02_SHEEP PLCB1 PLCB1 KCNH1 KCNH1 MARCKS MARCKS SPTAN1 SPTAN1 PCP4 PCP4 MYO1C MYO1C PHKA1 PHKA1 CAMKK1 CAMKK1 CNN3 CNN3 TTN TTN TRPV1 TRPV1 TRPV6 TRPV6 IQGAP2 IQGAP2 ARPP21 ARPP21 PHKB PHKB CAMSAP2 CAMSAP2 NOS2 NOS2 PDE1A PDE1A MYH2 MYH2 CFAP221 CFAP221 SLC24A4 SLC24A4 MYO10 MYO10 CAMK4 CAMK4 AKAP5 AKAP5 SCN5A SCN5A EDF1 EDF1 MYLK2 MYLK2 MYH10 MYH10 SYT2 SYT2 W5NUL6_SHEEP W5NUL6_SHEEP W5PAD7_SHEEP W5PAD7_SHEEP IQCF6 IQCF6 CAMK2A CAMK2A PNCK PNCK SPHK1 SPHK1 PHKG2 PHKG2 SLC8A1 SLC8A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3CBSerine/threonine-protein phosphatase. (501 aa)
W5PD11_SHEEPNa_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (384 aa)
MYO1AMyosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1126 aa)
WDR64WD repeat domain 64. (1092 aa)
SMTNL1Calponin-homology (CH) domain-containing protein. (162 aa)
STRNStriatin. (780 aa)
MYO1DMyosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (930 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (390 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5183 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (309 aa)
SPA17Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. (161 aa)
MAPKAPK5MAPK activated protein kinase 5. (474 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2121 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
CNN1Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). (297 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
IQCB1IQ motif containing B1. (598 aa)
MYLKMyosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessa [...] (1930 aa)
IQCGIQ motif containing G. (438 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (588 aa)
MAP6D1MAP6 domain containing 1. (181 aa)
MYO1EMyosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
UNC13CUnc-13 homolog C. (2214 aa)
MARCKSL1MARCKS like 1. (241 aa)
KCNH5Potassium voltage-gated channel subfamily H member 5. (988 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
STRN4Striatin 4. (659 aa)
CAMSAP3Calmodulin regulated spectrin associated protein family member 3. (1105 aa)
GAP43Growth associated protein 43. (192 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
W5NV97_SHEEPUncharacterized protein. (239 aa)
SPEGNBI-set domain-containing protein. (174 aa)
W5NVT1_SHEEPCation_ATPase_C domain-containing protein. (188 aa)
W5NVU9_SHEEPUncharacterized protein. (147 aa)
EPB41Erythrocyte membrane protein band 4.1. (1020 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (433 aa)
KCNQ1Ion_trans domain-containing protein; Belongs to the potassium channel family. (383 aa)
LOC101105884Uncharacterized protein. (181 aa)
KCNN3Potassium calcium-activated channel subfamily N member 3. (719 aa)
W5NYC3_SHEEPUncharacterized protein. (189 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (96 aa)
AKAP12A-kinase anchoring protein 12. (1853 aa)
ENKUREnkurin, TRPC channel interacting protein. (259 aa)
FBXL20F-box and leucine rich repeat protein 20. (527 aa)
INVSInversin. (1087 aa)
RYR2Ryanodine receptor 2. (4788 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1691 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2147 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG. (474 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2174 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
W5PWI7_SHEEPCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (272 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5; Belongs to the potassium channel family. (723 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (758 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (827 aa)
CAMKVCaM kinase like vesicle associated. (498 aa)
MYH1Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
SPATA17Spermatogenesis associated 17. (362 aa)
FBXO41F-box protein 41. (694 aa)
MAP6Microtubule associated protein 6. (944 aa)
NDUFAF4Uncharacterized protein. (181 aa)
UNC13BUnc-13 homolog B. (1590 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (498 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1272 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (892 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (464 aa)
IQCF3Uncharacterized protein. (187 aa)
IQCF2IQ motif containing F2. (163 aa)
IQCF5IQ motif containing F5. (177 aa)
IQCF1IQ motif containing F1. (210 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (747 aa)
PYY-2Uncharacterized protein. (81 aa)
MAPKAPK2MAPK activated protein kinase 2. (309 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1633 aa)
NGFRNerve growth factor receptor. (436 aa)
CDK5RAP2CDK5 regulatory subunit associated protein 2. (1844 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3442 aa)
FASFas cell surface death receptor. (326 aa)
SYT1Synaptotagmin 1. (422 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (385 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (920 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1628 aa)
NOS1Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
W5P2N0_SHEEPUncharacterized protein. (179 aa)
RIT1Uncharacterized protein. (234 aa)
CAMSAP1Calmodulin regulated spectrin associated protein 1. (1491 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1213 aa)
RYR1Ryanodine receptor 1. (4903 aa)
STRN3Striatin 3. (705 aa)
NRGNNeurogranin. (73 aa)
EEF2KEukaryotic elongation factor 2 kinase. (723 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (664 aa)
W5Q2E9_SHEEPUncharacterized protein. (148 aa)
FBXL2F-box and leucine rich repeat protein 2. (441 aa)
W5PD66_SHEEPAGC-kinase C-terminal domain-containing protein. (403 aa)
SNTA1Syntrophin alpha 1. (598 aa)
UNC13AUnc-13 homolog A. (1727 aa)
PDE1BPhosphodiesterase. (535 aa)
W5Q3L8_SHEEPUncharacterized protein. (368 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (724 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (547 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (663 aa)
MIPLens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
ATP2B4Uncharacterized protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (478 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (430 aa)
W5PH02_SHEEPCation_ATPase_N domain-containing protein. (245 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
KCNH1Uncharacterized protein. (1013 aa)
MARCKSUncharacterized protein. (77 aa)
SPTAN1SH3 domain-containing protein. (2257 aa)
PCP4Purkinje cell protein 4. (59 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1067 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1249 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (426 aa)
CNN3Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (311 aa)
TTNTitin. (32000 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1. (592 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (723 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
ARPP21cAMP regulated phosphoprotein 21. (806 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1087 aa)
CAMSAP2Calmodulin regulated spectrin associated protein family member 2. (1367 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
PDE1APhosphodiesterase. (514 aa)
MYH2Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1932 aa)
CFAP221Cilia and flagella associated protein 221. (837 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2016 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (333 aa)
AKAP5A-kinase anchoring protein 5. (423 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1932 aa)
EDF1Endothelial differentiation related factor 1. (148 aa)
MYLK2Myosin light chain kinase 2. (626 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
SYT2C2 domain-containing protein. (89 aa)
W5NUL6_SHEEPCation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (369 aa)
W5PAD7_SHEEPUncharacterized protein. (174 aa)
IQCF6IQ motif containing F6. (157 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
PNCKPregnancy up-regulated nonubiquitous CaM kinase. (343 aa)
SPHK1Sphingosine kinase 1. (459 aa)
PHKG2PHKG2; Belongs to the protein kinase superfamily. (406 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (602 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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