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TDO2 TDO2 ACSS1 ACSS1 DLAT DLAT NUDT8 NUDT8 W5QIT2_SHEEP W5QIT2_SHEEP PDHX PDHX AASS AASS W5Q1I4_SHEEP W5Q1I4_SHEEP ACLY ACLY HMGCS2 HMGCS2 PPCS PPCS ACACA ACACA DLST DLST PMVK PMVK PIPOX PIPOX ACACB ACACB PDHA2 PDHA2 ACOT12 ACOT12 LOC101103029 LOC101103029 MVK MVK PDHA1 PDHA1 W5PUA6_SHEEP W5PUA6_SHEEP MVD MVD MPC2 MPC2 PDHB PDHB ACAT1 ACAT1 ACSS2 ACSS2 MLYCD MLYCD HMGCS1 HMGCS1 NUDT7 NUDT7 DLD DLD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
ACSS1Acetyl-coenzyme A synthetase. (579 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
NUDT8Uncharacterized protein. (73 aa)
W5QIT2_SHEEPDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (562 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
AASSAminoadipate-semialdehyde synthase. (926 aa)
W5Q1I4_SHEEPAminotran_1_2 domain-containing protein. (269 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
PPCSPhosphopantothenoylcysteine synthetase. (319 aa)
ACACAAcetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. (2257 aa)
DLSTDihydrolipoamide S-succinyltransferase. (455 aa)
PMVKPhosphomevalonate kinase. (192 aa)
PIPOXPipecolic acid and sarcosine oxidase. (393 aa)
ACACBAcetyl-CoA carboxylase beta. (2454 aa)
PDHA2Pyruvate dehydrogenase E1 alpha 2 subunit. (358 aa)
ACOT12Acyl-CoA thioesterase 12. (559 aa)
LOC101103029Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (441 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
W5PUA6_SHEEPPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (355 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (391 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
MLYCDMalonyl-CoA decarboxylase. (353 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (566 aa)
NUDT7Nudix hydrolase 7. (238 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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