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| | RAD21L1 | RAD21 cohesin complex component like 1. (554 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1021 aa) |
| | WRN | WRN RecQ like helicase. (1406 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (571 aa) |
| | W5NQE5_SHEEP | C2 domain-containing protein. (623 aa) |
| | W5NQJ4_SHEEP | Uncharacterized protein. (422 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (203 aa) |
| | INTS3 | Integrator complex subunit 3. (1040 aa) |
| | W5NT16_SHEEP | Uncharacterized protein. (437 aa) |
| | YY1 | YY1 transcription factor. (348 aa) |
| | W5NUN9_SHEEP | MRG domain-containing protein. (158 aa) |
| | WDR48 | WD repeat domain 48. (677 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1481 aa) |
| | W5NVE3_SHEEP | DUF2439 domain-containing protein. (1055 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1732 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | RAD54L | RAD54 like. (750 aa) |
| | ZGRF1 | Uncharacterized protein. (1049 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | CHEK2 | Checkpoint kinase 2. (536 aa) |
| | HELQ | Helicase, POLQ like. (1064 aa) |
| | MCM2 | MCM domain-containing protein; Belongs to the MCM family. (237 aa) |
| | MBTD1 | Mbt domain containing 1. (632 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (401 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (318 aa) |
| | UIMC1 | RAP80_UIM domain-containing protein. (514 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (612 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | RMI1 | RecQ mediated genome instability 1. (623 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (293 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (826 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | W5P2F8_SHEEP | Uncharacterized protein. (68 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (590 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1857 aa) |
| | W5P4T8_SHEEP | Uncharacterized protein. (71 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1062 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | W5P523_SHEEP | Uncharacterized protein. (239 aa) |
| | FANCD2 | FA complementation group D2. (1454 aa) |
| | LIG4 | DNA ligase. (757 aa) |
| | GGN | Gametogenetin. (494 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (373 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (281 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (381 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (790 aa) |
| | RNF138 | Ring finger protein 138. (199 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (352 aa) |
| | SETX | Senataxin. (2662 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | RMI2 | RecQ mediated genome instability 2. (159 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | W5P9H5_SHEEP | Poly [ADP-ribose] polymerase. (167 aa) |
| | W5P9K2_SHEEP | Reverse transcriptase domain-containing protein. (629 aa) |
| | PARP3 | PARP alpha-helical domain-containing protein. (260 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (309 aa) |
| | W5PAN5_SHEEP | MCM domain-containing protein; Belongs to the MCM family. (871 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (514 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (693 aa) |
| | RAD54B | Uncharacterized protein. (811 aa) |
| | W5PCX4_SHEEP | Uncharacterized protein. (69 aa) |
| | IFFO1 | Intermediate filament family orphan 1; Belongs to the intermediate filament family. (536 aa) |
| | C5H19orf57 | Uncharacterized protein. (659 aa) |
| | LIG3 | DNA ligase. (1010 aa) |
| | W5PED2_SHEEP | Uncharacterized protein. (797 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (153 aa) |
| | RBBP8 | Uncharacterized protein. (887 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (277 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1. (1743 aa) |
| | MEIOC | Meiosis specific with coiled-coil domain. (963 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (632 aa) |
| | W5PGH4_SHEEP | Tankyrase_bdg_C domain-containing protein. (1520 aa) |
| | KDM2A | Lysine demethylase 2A. (1159 aa) |
| | FANCM | FA complementation group M. (2043 aa) |
| | W5PI72_SHEEP | SAP domain-containing protein. (565 aa) |
| | APTX | Aprataxin. (356 aa) |
| | NABP2 | Nucleic acid binding protein 2. (154 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1872 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3056 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (328 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (299 aa) |
| | RECQL5 | RecQ like helicase 5. (1014 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1974 aa) |
| | RAD21 | RAD21 cohesin complex component. (630 aa) |
| | IFFO2 | Intermediate filament family orphan 2. (405 aa) |
| | RNF169 | Ring finger protein 169. (548 aa) |
| | NIPBL | Nipped-B protein. (2804 aa) |
| | SIRT6 | Sirtuin 6. (361 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | SWI5 | Uncharacterized protein. (171 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (757 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (487 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3427 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (263 aa) |
| | RAD51B | RAD51 paralog B. (290 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2521 aa) |
| | C14orf39 | Chromosome 14 open reading frame 39. (584 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | SLFNL1 | Schlafen like 1. (404 aa) |
| | TM4SF19 | Uncharacterized protein. (208 aa) |
| | INO80 | INO80 complex ATPase subunit. (1565 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (685 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (827 aa) |
| | POLQ | DNA polymerase theta. (2739 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (541 aa) |
| | APLF | Aprataxin and PNKP like factor. (506 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (198 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (552 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (950 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (334 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (155 aa) |
| | RAD51C | RAD51 paralog C. (384 aa) |
| | W5PPW4_SHEEP | Uncharacterized protein. (191 aa) |
| | FANCB | FA complementation group B. (858 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4120 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1245 aa) |
| | W5PQY7_SHEEP | Uncharacterized protein. (393 aa) |
| | VCP | Valosin containing protein; Belongs to the AAA ATPase family. (812 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (288 aa) |
| | UVRAG | C2 domain-containing protein. (661 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (416 aa) |
| | FBH1 | F-box DNA helicase 1. (1046 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (773 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (140 aa) |
| | SMC5 | SMC_N domain-containing protein. (1167 aa) |
| | RECQL4 | RecQ like helicase 4. (1105 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (564 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1363 aa) |
| | EPC1 | Enhancer of polycomb homolog. (813 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1051 aa) |
| | PNKP | FHA_2 domain-containing protein. (303 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (887 aa) |
| | NABP1 | Nucleic acid binding protein 1. (208 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | W5PYR2_SHEEP | MRG domain-containing protein. (360 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (451 aa) |
| | MORF4L1 | Mortality factor 4 like 1. (360 aa) |
| | ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (734 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1444 aa) |
| | POLN | DNA polymerase nu. (901 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (332 aa) |
| | W5Q287_SHEEP | HTH_48 domain-containing protein. (338 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (627 aa) |
| | CDC7 | Cell division cycle 7. (582 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (409 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1022 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (995 aa) |
| | DDX1 | DEAD-box helicase 1. (736 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (352 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1153 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1101 aa) |
| | MEIOB | Uncharacterized protein. (202 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (919 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (617 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (488 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1194 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (611 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (654 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (733 aa) |
| | REC8 | REC8 meiotic recombination protein. (592 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (145 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (543 aa) |
| | CDC45 | Cell division cycle 45. (549 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (713 aa) |
| | SMARCAD1 | Uncharacterized protein. (1028 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (395 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (835 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) |
| | XRCC6 | SAP domain-containing protein. (612 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (830 aa) |
